The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and org ....The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and organ development. In studying this process the project should provide critical insights into how cells act, individually and collectively, to build tissues.Read moreRead less
Understanding how cells compact and segregate DNA in vertebrates. How a cell compacts and divides its DNA is still a major unanswered question in biology. This project will determine the way in which a cell compacts its DNA nearly ten thousand fold to allow the faithful and accurate segregation to daughter nuclei.
Mobility of log-dependent invertebrates in fragmented forest. Clearing of Australian native forests continues apace. This leads to declines in total forest area and creates isolated remnants with depleted woody debris. Critical forest processes driven by invertebrates occur in this debris. Despite its major economic and conservation significance, there is little information on the impacts of habitat loss and alteration on organisms in decomposing logs. We will utilize recent advances in popu ....Mobility of log-dependent invertebrates in fragmented forest. Clearing of Australian native forests continues apace. This leads to declines in total forest area and creates isolated remnants with depleted woody debris. Critical forest processes driven by invertebrates occur in this debris. Despite its major economic and conservation significance, there is little information on the impacts of habitat loss and alteration on organisms in decomposing logs. We will utilize recent advances in population genetics to compare impacts on a suite of log-dependent invertebrates in an islands-of-bush-in-a-sea-of-pines model. This will facilitate improvements in conservation and sustainable management outcomes in forests.Read moreRead less
Improved biomonitoring of urban freshwater ecosystems using DNA barcodes. This project aims to provide rapid diagnostic detection of environmental change in aquatic ecosystems at reduced cost. Next-generation sequencing (NGS) can transform monitoring of aquatic ecosystems by identifying many species in multiple biological samples. This project aims to use NGS technology to identify macroinvertebrate species as biological indicators in urban freshwater ecosystems to provide more rapid, sensitive ....Improved biomonitoring of urban freshwater ecosystems using DNA barcodes. This project aims to provide rapid diagnostic detection of environmental change in aquatic ecosystems at reduced cost. Next-generation sequencing (NGS) can transform monitoring of aquatic ecosystems by identifying many species in multiple biological samples. This project aims to use NGS technology to identify macroinvertebrate species as biological indicators in urban freshwater ecosystems to provide more rapid, sensitive and cost-effective monitoring compared to traditional methods. The project uses DNA barcodes that identify species to detect species in samples processed with NGS. The project also plans to use previously collected samples to explore species diversity and detect indicator species.Read moreRead less
Fisheries genomics of snapper in Australia and New Zealand Waters. This industry-driven project aims to assemble a strategic research alliance to generate and apply knowledge to a highly significant fisheries resource. It involves collaboration between the five major state government fisheries agencies in Australia, the New Zealand’s Crown Research Institute for seafood and two Australian labs with leadership in fish genetics and genomics. It expects to generate and integrate genomic, environmen ....Fisheries genomics of snapper in Australia and New Zealand Waters. This industry-driven project aims to assemble a strategic research alliance to generate and apply knowledge to a highly significant fisheries resource. It involves collaboration between the five major state government fisheries agencies in Australia, the New Zealand’s Crown Research Institute for seafood and two Australian labs with leadership in fish genetics and genomics. It expects to generate and integrate genomic, environmental and phenotypic datasets for snapper populations from across vast coastal regions of the two countries. The outcomes should substantially enhance intra- and inter-jurisdictional fisheries management and aquaculture initiatives, providing commercial, social and environmental benefits for many stakeholders.Read moreRead less
Genomics for persistence of Australian freshwater fish. Biodiversity faces an unpredictable cocktail of impacts and global environmental change, against which the best insurance is genetic diversity. We will develop genomic measures of ecological-genetic functions and evolutionary potential for managing Australian freshwater fish.
The success and rapid evolution of invasive species: resolving a genetic paradox. Invasive species have an enormous economic impact on trade, agriculture, aquaculture, fisheries and eco-tourism in Australia. In order to negate such detrimental impacts, integrated strategies need to be formulated to effectively control and eradicate introduced species. Our limited knowledge of the factors underlying the success of invasive species has hampered such efforts. A detailed understanding of the invasio ....The success and rapid evolution of invasive species: resolving a genetic paradox. Invasive species have an enormous economic impact on trade, agriculture, aquaculture, fisheries and eco-tourism in Australia. In order to negate such detrimental impacts, integrated strategies need to be formulated to effectively control and eradicate introduced species. Our limited knowledge of the factors underlying the success of invasive species has hampered such efforts. A detailed understanding of the invasion dynamics of introduced species is essential for identifying potential weaknesses that can be exploited in management strategies. My research will examine the invasion dynamics of a successful invasive species, the delicate skink, providing information directly relevant to the management of introduced species in Australia.Read moreRead less
Using mouse genetics to understand skin development and cell biology. During embryonic development the skin forms a protective barrier which permits life outside the womb and provides a window into the biology of cells. This project aims to use the skin to identify and characterise genes necessary for embryonic development and maintenance, the development of diseases and to explore their broader roles in other organs.
The effects of habitat fragmentation on dispersal and social organisation in the Brown Antechinus. Fragmentation of native habitat continues to threaten Australian species, yet we have little understanding of processes leading to resulting extinctions. This study will characterise the effects of human-induced habitat fragmentation on social organisation and dispersal in Brown Antechinus. We will use a combination of genetic and demographic analyses to quantify and describe perturbation of social ....The effects of habitat fragmentation on dispersal and social organisation in the Brown Antechinus. Fragmentation of native habitat continues to threaten Australian species, yet we have little understanding of processes leading to resulting extinctions. This study will characterise the effects of human-induced habitat fragmentation on social organisation and dispersal in Brown Antechinus. We will use a combination of genetic and demographic analyses to quantify and describe perturbation of social structure and mating system within habitat fragments, and of dispersal among them. The patchwork of native vegetation within the Tumut pine plantation provides an ideal natural experimental study system and will produce data essential for rational management of landscapes in the face of human disturbance.Read moreRead less
Genetic variation without sex: frequency-dependent selection and the maintenance of variation in asexual organisms. The proposed research will gain insight into one of the most fundamental yet puzzling questions in evolutionary biology and determine the generality of frequency-dependent selection as a mechanism for maintaining variation in asexual organisms. The results will have broad appeal, both internationally and nationally, and will also provide insight into why most species reproduce sexu ....Genetic variation without sex: frequency-dependent selection and the maintenance of variation in asexual organisms. The proposed research will gain insight into one of the most fundamental yet puzzling questions in evolutionary biology and determine the generality of frequency-dependent selection as a mechanism for maintaining variation in asexual organisms. The results will have broad appeal, both internationally and nationally, and will also provide insight into why most species reproduce sexually. The results will also help in the development of two asexual species as environmental indicators by linking clones with specific environmental changes. These indicator clones could then be adopted by natural resource managers to monitor environmental pollution and contamination.Read moreRead less