Understanding the molecular mechanisms of intellectual disability. Intellectual disability is frequent in the population, with one in every fifty people in the world directly affected. This project will improve our understanding of the correct development and function of the brain required for cognition by investigating specific roles and regulation of key molecules involved.
Complex trait analyses based on genome-wide approaches. This project aims to develop whole genome approaches that can improve the estimation and prediction power by using information from the dynamic genetic architecture of complex traits (i.e. the changes of genetic characteristics and effects when varying effective population size and genetic backgrounds). The project intends to deliver advanced statistical models, efficient algorithms and design by combining data from close relatives, populat ....Complex trait analyses based on genome-wide approaches. This project aims to develop whole genome approaches that can improve the estimation and prediction power by using information from the dynamic genetic architecture of complex traits (i.e. the changes of genetic characteristics and effects when varying effective population size and genetic backgrounds). The project intends to deliver advanced statistical models, efficient algorithms and design by combining data from close relatives, population samples or from different populations (e.g. multi-ethnicities or multi-breeds). The expected outcome is to better understand the dynamic architecture of complex traits and develop methods with improved power, precision and accuracy in genomic analyses.Read moreRead less
Measuring mantle hydrogen to map ore fluids and model plate tectonics. The goal of this project is to use magnetotellurics to measure mantle hydrogen content to aid in the discovery of new mineral deposits. Hydrogen controls the strength of Earth’s mantle and is a vital component of the systems that form giant ore deposits. However, mantle hydrogen content is unconstrained. Ore-forming fluids hydrate the mantle pathways on which they travel. The first aim of this project is to image these fluid ....Measuring mantle hydrogen to map ore fluids and model plate tectonics. The goal of this project is to use magnetotellurics to measure mantle hydrogen content to aid in the discovery of new mineral deposits. Hydrogen controls the strength of Earth’s mantle and is a vital component of the systems that form giant ore deposits. However, mantle hydrogen content is unconstrained. Ore-forming fluids hydrate the mantle pathways on which they travel. The first aim of this project is to image these fluid pathways to improve mineral exploration techniques. Plate tectonic models assume that the lithospheric mantle is dehydrated but existing data from magnetotellurics and mantle rocks show high hydrogen contents. The second aim of this project is to create a map of the hydrogen content of the plates, which may lead to new models for continental evolution and mantle dynamics.Read moreRead less
Improved theory and practice in econometric modelling of nonlinear spatial time series. Modern Australia faces many challenges in economic and global climate changes, which require advanced statistical technologies in modeling and forecasting of econometric spatial time series data. This project will provide flexible models and methods that enable practitioners to more accurately measure and manage economic and climatic risks.
Advanced biosensing in the terahertz (THz) sub-wavelength regime. This project will build on Australian excellence in photonics, exploiting the advanced use of T-rays for sensing of biological substances such as proteins and DNA. For the first time, this will enable contactless automated sensing for high-speed medical screening of diseases, a critical step toward the ultimate vision of customised medicine.