Identification of Traits and Function by Genomic Matching. Differences between individuals are largely inherited and therefore encoded within the DNA. The challenge is to develop practical means of detecting these differences irrespective of whether they are observable as a phenotype.
Here we focus on livestock. For example, most Australian cattle are horned rather than polled. The inheritance is relatively simple but there is still no DNA test to detect the recessive horning gene.
T ....Identification of Traits and Function by Genomic Matching. Differences between individuals are largely inherited and therefore encoded within the DNA. The challenge is to develop practical means of detecting these differences irrespective of whether they are observable as a phenotype.
Here we focus on livestock. For example, most Australian cattle are horned rather than polled. The inheritance is relatively simple but there is still no DNA test to detect the recessive horning gene.
The genomic matching technique is an in-house patented procedure for identifying such DNA differences. If successful, our test will assist industry to eliminate horning and thereby painful dehorning whilst reducing damage to workers and product.
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Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Identifying the diversity and evolution of loci associated with adaptation to aridity/heat and salinity in ancient cereal crops. This project will use ancient grains of wheat, barley and rye to find 'lost' genetic diversity at key genes associated with resistance to aridity, salt and disease. This project will make the proteins of key genes, and study their interaction with the environment over time by measuring ions in the grains to reveal the ancient environmental conditions.
Modelling stock market liquidity in Australia and the Asia Pacific Region. This project will develop new methods of assessing stock market liquidity in Australia and the Asia-Pacific region. These methods will use high frequency transactions-based data provided by the industry partner, SIRCA. The data will be the basis of smart information real time algorithms for measuring market liquidity. They will incorporate generalizations and extensions of recent developments in time series econometrics, ....Modelling stock market liquidity in Australia and the Asia Pacific Region. This project will develop new methods of assessing stock market liquidity in Australia and the Asia-Pacific region. These methods will use high frequency transactions-based data provided by the industry partner, SIRCA. The data will be the basis of smart information real time algorithms for measuring market liquidity. They will incorporate generalizations and extensions of recent developments in time series econometrics, and will be calibrated and evaluated statistically. The novel methods will be crucial to market participants and to regulators, who will be able to apply them to assess market depth and liquidity, and reduce trading costs substantially.Read moreRead less
Digging deeper to improve yield stability. This project aims to provide innovative breeding solutions that harness the ‘hidden’ part of the plant, roots, to support the development of more productive crops in the face of climate variability. The project expects to generate new insights into the biology and genetics of root development in barley, a model cereal crop, by applying cutting-edge genome editing, phenotyping and genomics technologies. Anticipated outcomes include novel methodologies to ....Digging deeper to improve yield stability. This project aims to provide innovative breeding solutions that harness the ‘hidden’ part of the plant, roots, to support the development of more productive crops in the face of climate variability. The project expects to generate new insights into the biology and genetics of root development in barley, a model cereal crop, by applying cutting-edge genome editing, phenotyping and genomics technologies. Anticipated outcomes include novel methodologies to accelerate breeding for diverse production environments, with direct applications in barley, and other major cereals including wheat and oats. This should provide significant economic and social benefits to the Australian grains industry through yield stability amidst climate variability.Read moreRead less
Optimisation of cell culture and molecular typing for the characterisation of Cryptosporidium in water. Cryptosporidium is an important waterborne agent of diarrhoeal disease in people and animals. Improved methods for accurately detecting viable parasite stages recovered from water are a priority research need for the water industry. They are dependent upon improved in vitro cultivation procedures that can be combined with DNA-based assays for identifying species and strains of Cryptosporidi ....Optimisation of cell culture and molecular typing for the characterisation of Cryptosporidium in water. Cryptosporidium is an important waterborne agent of diarrhoeal disease in people and animals. Improved methods for accurately detecting viable parasite stages recovered from water are a priority research need for the water industry. They are dependent upon improved in vitro cultivation procedures that can be combined with DNA-based assays for identifying species and strains of Cryptosporidium and closely related protozoa recovered from freshwater. This project addresses these needs in a collaborative study between scientists at Murdoch University with expertise in both in vitro cultivation and genetic characterisation of Cryptosporidium, and scientists from two of the major water utilities in Australia.Read moreRead less
The Relevance of the Bovine Major Histocompatibility Complex (MHC) to Milk Production. The objective of this project is to provide the dairy industry with an integrated package that includes a ?dairy performance database? linked to DNA-based information to complement existing breeding practices. Our intention is increase the profitability of the dairy industry, hence making a dairy farm a sustainable venture in a deregulated environment. Profitability results from a combination of several fact ....The Relevance of the Bovine Major Histocompatibility Complex (MHC) to Milk Production. The objective of this project is to provide the dairy industry with an integrated package that includes a ?dairy performance database? linked to DNA-based information to complement existing breeding practices. Our intention is increase the profitability of the dairy industry, hence making a dairy farm a sustainable venture in a deregulated environment. Profitability results from a combination of several factors. The drivers of the industry include political, market, environmental, husbandry, nutrition, and genetic factors. These factors are interrelated. In this proposal, we are specifically interested in the relationship between milk yields and the DNA profile of dairy cattle.Read moreRead less
Energy-saving design: investigation of the thermal performance of rammed earth residential buildings. Housing people in Australian remote communities is energy intensive. This is particularly true in hot regions, where the house running costs are significant due to air-conditioning units functioning 24 hours a day, for most of the year. Rammed earth houses in dry-arid climate zones should not require any air-conditioning in summer. This project aims to investigate the optimal thermal performance ....Energy-saving design: investigation of the thermal performance of rammed earth residential buildings. Housing people in Australian remote communities is energy intensive. This is particularly true in hot regions, where the house running costs are significant due to air-conditioning units functioning 24 hours a day, for most of the year. Rammed earth houses in dry-arid climate zones should not require any air-conditioning in summer. This project aims to investigate the optimal thermal performance of two occupied houses using a novel sensor network. It aims to deliver new evidence on the thermal performance of rammed earth buildings to inform energy-efficiency decision frameworks and enhance the wellbeing of Indigenous communities in hot regions.Read moreRead less
Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of dri ....Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of driving fluid flow thorough the lithosphere, mineralisation phenomena, their datasets and geometries, and dynamic aspects of the processes driving mineral systems.Read moreRead less
Establishing novel breeding methods for canola improvement. It is imperative to ensure reliable food production in the coming years of climate change and increasing population. Genomics offers the greatest potential to increase food production. This project will apply genomic selection methods to accelerate canola oilseed breeding to ensure continued increases in production of this important food and national export.