Protocol Development, Web-based Data Collection And Data Quality For All Cancer Cooperative Trials Groups
Funder
National Health and Medical Research Council
Funding Amount
$1,840,000.00
Summary
Each year, 85,000 Australian develop cancer and 35,000 die of it. The Clinical Oncological Society of Australia and nine Australian cancer trials groups run studies that test new and better ways of preventing, curing, treating and palliating people affected by cancer. This grant will help these groups start trials faster; run them more efficiently; coordinate quality assurance; and standardize operating procedures. This grant will enable collaboration that increases the speed, efficiency and qua ....Each year, 85,000 Australian develop cancer and 35,000 die of it. The Clinical Oncological Society of Australia and nine Australian cancer trials groups run studies that test new and better ways of preventing, curing, treating and palliating people affected by cancer. This grant will help these groups start trials faster; run them more efficiently; coordinate quality assurance; and standardize operating procedures. This grant will enable collaboration that increases the speed, efficiency and quality of cancer research to lessen the suffering of people affected by cancer.Read moreRead less
3D-BrachyView: A 3D Real-time Virtual Reality Intra-operative Quality Assurance System For Brachytherapy
Funder
National Health and Medical Research Council
Funding Amount
$359,105.00
Summary
3D-Brachyview aims to bring 3D virtual reality into the Quality Assurance and training of physicists in prostate cancer brachytherapy. The 3D simultaneous visualisation of the position of the seeds implanted, the actual shape and position of the prostate, and the expected treatment plan, will help doctors to deliver the best treatment possible.
Improving Radiation Therapy Of Static And Moving Targets Using High Spatial Resolution Real-time Dosimeters
Funder
National Health and Medical Research Council
Funding Amount
$544,425.00
Summary
Radiation therapy is a major oncology modality for cancer treatment and more than 50% of cancer patients can benefit from radiotherapy at some stage of management. This project will develop two real-time, high spatial resolution dosimetry systems for quality assurance of contemporary radiation treatments of static and movable targets. It will be possible to minimize human and robotic system error so as to guarantee accurate cancer treatment delivery and improve the clinical outcomes of radiother ....Radiation therapy is a major oncology modality for cancer treatment and more than 50% of cancer patients can benefit from radiotherapy at some stage of management. This project will develop two real-time, high spatial resolution dosimetry systems for quality assurance of contemporary radiation treatments of static and movable targets. It will be possible to minimize human and robotic system error so as to guarantee accurate cancer treatment delivery and improve the clinical outcomes of radiotherapy.Read moreRead less
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.
Fast And Efficient Assessment Of Dose In Small Targets In Radiotherapy: Effect Of Motion In Clinical Research And Implementation Of Dynamic Therapy
Funder
National Health and Medical Research Council
Funding Amount
$501,265.00
Summary
The continued progress of radiation therapy for cancer patients has been driven by technology developments that have increased the complexity of radiation delivery, but has come at the cost of increased potential for errors in radiation planning and delivery. The aim of this project is to implement an instrument for verification of treatment delivered to organs with large variation of shape and position due to respiration. This will enhance treatment outcome and patient quality of life.
Unifying And Quality Assuring Disparate Health Silos With A Common Data Model
Funder
National Health and Medical Research Council
Funding Amount
$735,795.00
Summary
Australia has silos of disconnected data holdings across various domains in community, primary and secondary care settings, with disparate terminologies, data models and data quality assurance mechanisms. Mapping MedicineInsight, a national general practice data repository, to a common data model can contribute to unifying Australia's digital data assets. There are cost-efficiencies and benefits from sharing interoperable data and tools for large-scale multicentre and multisystem data analytics.
Highly Pathogenic Avian Influenza (HPAI) - Improved Diagnosis With Quality Assurance Of Serological & Molecular Diagnost
Funder
National Health and Medical Research Council
Funding Amount
$249,019.00
Summary
This project aims to produce Quality Assurance (QA) algorithms to ensure accurate diagnosis of highly pathogenic avian influenza (HPAI) using serological and molecular techniques. The project will assess HPAI diagnosis accurately within the setting of other circulating respiratory illnesses, utilising a new HPAI module, ,in combination with existing modules within the Royal College of Pathologists of Australia (RCPA) Serology Quality Assurance Program (SQAP). This will ensure rapid, cost-efficie ....This project aims to produce Quality Assurance (QA) algorithms to ensure accurate diagnosis of highly pathogenic avian influenza (HPAI) using serological and molecular techniques. The project will assess HPAI diagnosis accurately within the setting of other circulating respiratory illnesses, utilising a new HPAI module, ,in combination with existing modules within the Royal College of Pathologists of Australia (RCPA) Serology Quality Assurance Program (SQAP). This will ensure rapid, cost-efficient improvements in diagnostics by utilizing existing infrastructure. The key elements of the project are: Introduction of quality assurance processes to ensure accurate diagnosis and to evaluate existing and developing laboratory testing procedures, test accuracy, and result interpretation; Involvement of human and veterinary laboratories in the QA and development processes; Production of suitable antigenic material through molecular virology as targets for HPAI antibody and molecular diagnostics in QA programs. This will thereby allow large quantities of non-infectious material for HPAI QA assessment of serological and molecular assays around Australia, using baculovirus expressed antigens and cloned gene targets respectively. These projects are designed within a short (<12 month) time frame in order to fulfil the needs of the Australian community in controlling the developing HPAI avian pandemic, and the possible human pandemic. Significant positive outcomes in the next six months are assured by the existence of current QA processes, experience in influenza research already available in the human and animal health laboratories involved, the research records of the groups, and the close existing linkages between the research, QA, diagnostic and avian virology groups.Read moreRead less