A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle d ....Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle deposition in human lung through experimental studies and advanced modelling. The program will enhance and strengthen the existing collaboration between the universities and its outcome will be of significance in the vital area of human health and risk assessment.Read moreRead less
Adaptive ecotyping of the toxic cyanobacterium Cylindrospermopsis raciborskii to predict its invasive capacity. We change the world while other organisms adapt to these new conditions. Cyanobacteria (blue green algae) increasingly dominate water bodies that were previously free of these harmful blooms. To minimise the spread of these algae, this project will study the genetic basis that determines how rapidly they can evolve and adapt to a changing planet.
Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive pla ....Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive plant-soil-based biofilters for cost-effective removal of nitrogen from a range of polluted urban water sources. The project will open a potential for a new technological advancements in urban water management, while simultaneously providing benefits to the environment and community through greening and waterway protection.Read moreRead less
DEVELOPING SCIENTIFIC BASIS FOR THE RAPID DETECTION SYSTEM OF DIESEL VEHICLES WITH HIGH LEVEL OF EXHAUST EMISSIONS. Diesel vehicle exhaust is a significant source of air pollution leading to major human health problems. However, only a small fraction of vehicles with high exhaust emissions cause the majority of this pollution. Initially, this research will develop a model of dispersion of pollutants into the environment immediately after emission. This model will be the scientific foundation for ....DEVELOPING SCIENTIFIC BASIS FOR THE RAPID DETECTION SYSTEM OF DIESEL VEHICLES WITH HIGH LEVEL OF EXHAUST EMISSIONS. Diesel vehicle exhaust is a significant source of air pollution leading to major human health problems. However, only a small fraction of vehicles with high exhaust emissions cause the majority of this pollution. Initially, this research will develop a model of dispersion of pollutants into the environment immediately after emission. This model will be the scientific foundation for the development of an efficient and economical rapid detection system for those vehicles with high exhaust emissions. The major outcome is to improve air quality and lower the occurrence/severity of airborne pollution induced health effects.Read moreRead less
Optimisation of indoor air quality, thermal comfort and energy usage within buildings located in busy transit oriented urban developments. The socio-economic benefits to Australia from the project include (i) a novel holistic modelling tool to building design that maximises indoor comfort and provides acceptable air quality for the inhabitants whilst minimising energy usage in transit oriented urban developments; and (ii) estimation of energy consumption for different building designs and operat ....Optimisation of indoor air quality, thermal comfort and energy usage within buildings located in busy transit oriented urban developments. The socio-economic benefits to Australia from the project include (i) a novel holistic modelling tool to building design that maximises indoor comfort and provides acceptable air quality for the inhabitants whilst minimising energy usage in transit oriented urban developments; and (ii) estimation of energy consumption for different building designs and operation with respect to air quality and thermal comfort. The ultimate economic benefit of this research will be a reduction in health care costs and lost productivity as well as reduction of energy used and associated emissions. The research will also place Australia in the forefront of international progress and the race towards better methods for achieving environmental sustainability.Read moreRead less
Quantification of Traffic Generated Nano and Ultrafine Particle Dynamics and Toxicity in Transit Hubs and Transport Corridors. The socio-economic benefits to Australia will include (i) new knowledge for the multiparameter assessment of nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates (ii) a breakthrough in the scientific understanding of traffic generated particles in the urban atmosphere (iii) determining the toxicological impact of these ....Quantification of Traffic Generated Nano and Ultrafine Particle Dynamics and Toxicity in Transit Hubs and Transport Corridors. The socio-economic benefits to Australia will include (i) new knowledge for the multiparameter assessment of nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates (ii) a breakthrough in the scientific understanding of traffic generated particles in the urban atmosphere (iii) determining the toxicological impact of these particles on biological systems. The ultimate economic benefit will be improved urban design to lower human exposure to ultrafine particles, thus reducing health care cost and productivity losses. The research will also place Australia at the forefront of international progress towards better methods for achieving environmental sustainability.Read moreRead less
Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, ....Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, unprecedented in scope and resolution. Outcomes include an open access database to quantify and visualise intra-urban air pollution and human exposure and develop air quality maps and smoke pollution management tools. It is expected to advance the evidence-based management of air as a resource, increasing economic prosperity and enhancing human health and quality of life.Read moreRead less