Multiscale modelling: Applications to the Biomedical Sciences. 1) Significant reductions in the costs of developing pharmaceutical treatments, 2) Substantial reduction in hospitalisation costs, 3) Improved treatment of wounds, a significant cause of chronic ill-health which presently costs the Australian HealthCare System A$500,000,000/year.
Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The ....Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The proposed research will enhance Australia's reputation for developing novel quantitative techniques at the cutting edge of modern biology. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries.Read moreRead less
Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation. Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilag ....Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation. Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilage and will incorporate the unique structure of the dissimilar layers in articular cartilage. It will be used to study how these resist the propagation of an initiated crack and will offer significant insight into the desirable fracture properties of any replacement material for articular cartilage and will provide a basis for assessing replacement biomaterials.Read moreRead less
Optimal Control Computation and Analysis of Switched Systems with State and Control Constraints. DC/DC converters are widely used in power supply systems and hybrid power systems generate cleaner energy. Achieving optimum performance in these applications has high commercial and environmental impacts. New optimal control problems for such practical problems will be formulated and new unified optimization theory and methods for these optimal control problems will be obtained. The outcomes will en ....Optimal Control Computation and Analysis of Switched Systems with State and Control Constraints. DC/DC converters are widely used in power supply systems and hybrid power systems generate cleaner energy. Achieving optimum performance in these applications has high commercial and environmental impacts. New optimal control problems for such practical problems will be formulated and new unified optimization theory and methods for these optimal control problems will be obtained. The outcomes will enhance Australia's reputation in this cutting edge research, and contribute to achieving optimal performance of high commercial and environmental value applications. It will also facilitate international collaboration, and provide an excellent opportunity for research training.Read moreRead less
Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The futu ....Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The future development of 'personalized medicine' will rely upon understanding the function of human genes, as will progress in the agricultural sector. Rigorous statistical analysis and development of appropriate bioinformatic methods are crucial to biological sequence analysis in comparative genomics.Read moreRead less
Nonsmooth Optimization in Constrained Spline Interpolation. Traditional methods based on standard calculus may not work for optimization problems with constraints; however, such problems can be reformulated as nonsmooth problems that need special treatment. The project aims to approach several important problems in constrained spline interpolation and approximation, from the perspective of nonsmooth optimization. The research, which builds upon a recent breakthrough in the approach to the convex ....Nonsmooth Optimization in Constrained Spline Interpolation. Traditional methods based on standard calculus may not work for optimization problems with constraints; however, such problems can be reformulated as nonsmooth problems that need special treatment. The project aims to approach several important problems in constrained spline interpolation and approximation, from the perspective of nonsmooth optimization. The research, which builds upon a recent breakthrough in the approach to the convex best interpolation by the applicant and his collaborators, is expected to provide fundamental theory for Newton-type methods being used for these problems with a vast number of applications in data fitting and curve and surface design.Read moreRead less
Nonlocal Statistical Mechanics and Logarithmic Conformal Field Theory. Australia has an enviable track record as an innovator and developer of advanced materials. This project in strategic basic research consists of theoretical work within the disciplines of statistical mechanics and conformal field theory to determine the profound role of nonlocal interactions, such as connectivities, in determining the critical physical properties of materials. Connectivities play a significant role in diverse ....Nonlocal Statistical Mechanics and Logarithmic Conformal Field Theory. Australia has an enviable track record as an innovator and developer of advanced materials. This project in strategic basic research consists of theoretical work within the disciplines of statistical mechanics and conformal field theory to determine the profound role of nonlocal interactions, such as connectivities, in determining the critical physical properties of materials. Connectivities play a significant role in diverse applications such as the gelation of polymers, random fuse networks, the spatial spread of epidemics and bushfires and the tertiary recovery of oil. This research will be practically useful in engineering the physical properties of advanced materials such as liquid crystals, gels, polymers and other materials.Read moreRead less
Exact solution of generalized models of polymers and percolation in two dimensions. Originating with the work of Rodney Baxter, Australia is the world leader in exactly solvable lattice models in two dimensions. This project, in strategic basic research, aims to continue this tradition and extend it by solving exactly new classes of two-dimensional lattice models involving nonlocal degrees of freedom. Since this will lead to new universal classes of thermodynamic behaviours for a diverse range o ....Exact solution of generalized models of polymers and percolation in two dimensions. Originating with the work of Rodney Baxter, Australia is the world leader in exactly solvable lattice models in two dimensions. This project, in strategic basic research, aims to continue this tradition and extend it by solving exactly new classes of two-dimensional lattice models involving nonlocal degrees of freedom. Since this will lead to new universal classes of thermodynamic behaviours for a diverse range of polymer-like systems, the potential for exploitation and commercialization is almost limitless. Potential applications include percolation of contaminants through aquifers, the spatial spread of epidemics and bushfires, the tertiary recovery of oil and filtering drinking water.Read moreRead less
Yield strength and plastic flow of heterogeneous materials: Designing optimal composites and porous materials. A major goal of materials science is to design materials with improved functionality at lower weight, cost and size. It is important to guide this expensive and time-consuming process with sophisticated computer modelling. In this project we aim to model how and why composite and porous materials fail when they are placed under stress. Our results will make materials design more efficie ....Yield strength and plastic flow of heterogeneous materials: Designing optimal composites and porous materials. A major goal of materials science is to design materials with improved functionality at lower weight, cost and size. It is important to guide this expensive and time-consuming process with sophisticated computer modelling. In this project we aim to model how and why composite and porous materials fail when they are placed under stress. Our results will make materials design more efficient by providing a valuable experimental interpretive tool and a theoretical map for material optimization. Our models will also provide crucial information needed for modelling the behavior of composites in applications.Read moreRead less
Plantwide Control of Modern Chemical Processes from a Network Perspective. Complex plants increasingly appear in modern Australian process industries, particularly in mineral processing, petrochemical and renewable energies sectors. These plants represent vast capital costs and manufacture products at a very large scale. Improvement in control and operation of these processes can potentially provide significant economic benefits. The expected outcome of this research is an effective approach to ....Plantwide Control of Modern Chemical Processes from a Network Perspective. Complex plants increasingly appear in modern Australian process industries, particularly in mineral processing, petrochemical and renewable energies sectors. These plants represent vast capital costs and manufacture products at a very large scale. Improvement in control and operation of these processes can potentially provide significant economic benefits. The expected outcome of this research is an effective approach to improve operational safety, efficiency, product quality and manufacturing flexibility, helping to build a more efficient and environmental conscious Australian chemical industry. This project will also enhance Australia's scientific reputation in the frontier research area of advanced process control and management.Read moreRead less