Determining features that separate groups of protein sequences. This project aims to develop mathematical approaches for determining features that distinguish one group of proteins from another, based on their amino acid sequences. The groups of sequences will reflect different outcomes, so that identifying the fundamental features can result in targeted interventions against the poorer outcome. A simple comparison at each position or of known features can fail to determine robust differentiator ....Determining features that separate groups of protein sequences. This project aims to develop mathematical approaches for determining features that distinguish one group of proteins from another, based on their amino acid sequences. The groups of sequences will reflect different outcomes, so that identifying the fundamental features can result in targeted interventions against the poorer outcome. A simple comparison at each position or of known features can fail to determine robust differentiators and so more complex methods are required. The project will, for example, help identify HIV vaccine targets by comparing early HIV transmission sequences from those in chronic infection. The methods will be applicable to viral proteins where high mutation rates make this task even more complex.Read moreRead less
New Theory and Algorithms for Nonsmooth Optimisation with Application to Integer Programming. Mathematical optimisation plays a key role in a wide variety of applications in business, industry, engineering and science. For example, airlines cannot fly and radiation treatment for cancer cannot be delivered without solving (a series of) optimisation problems. Some classes of optimisation problem are very well solved, with clear mathematical foundations, efficient algorithms, and reliable software ....New Theory and Algorithms for Nonsmooth Optimisation with Application to Integer Programming. Mathematical optimisation plays a key role in a wide variety of applications in business, industry, engineering and science. For example, airlines cannot fly and radiation treatment for cancer cannot be delivered without solving (a series of) optimisation problems. Some classes of optimisation problem are very well solved, with clear mathematical foundations, efficient algorithms, and reliable software implementations. Both nonsmooth and integer optimisation problems have a good mathematical basis, but there are "gaps"; existing methods cannot always solve real industrial problems. This project will deliver better methods, built on better theory, and so will yield better solutions for important applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100049
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
New integer programming based theory, formulations and decomposition techniques with applications to integrated problems. Optimisation problems permeate science and industry. By developing new techniques to solve larger and harder problems than is currently possible, more complex questions can be answered, and more accurate solutions obtained. Industries can use such tools to make better financial, resource management, operational, and/or strategic planning decisions.
Discovery Early Career Researcher Award - Grant ID: DE170100234
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Exact and hybrid algorithms for the Aircraft Landing Problem. This project aims to develop algorithms with superior guaranteed performance. Aircraft Landing Problems (ALP) are an important class of decision problems. Optimal solution of an ALP is applicable in transportation and health care delivery, benefitting systems experiencing long delays. This project aims to address several of the Australian Government's Science and Research Priorities, focusing on food supply chains, effective operation ....Exact and hybrid algorithms for the Aircraft Landing Problem. This project aims to develop algorithms with superior guaranteed performance. Aircraft Landing Problems (ALP) are an important class of decision problems. Optimal solution of an ALP is applicable in transportation and health care delivery, benefitting systems experiencing long delays. This project aims to address several of the Australian Government's Science and Research Priorities, focusing on food supply chains, effective operation and resource allocation in transport, and better models of health care delivery and services.Read moreRead less
Improving train flows with connected driver advice systems. The project aims to develop new train control theory to determine the efficient movement of multiple trains, and to demonstrate a practical system for coordinating trains, on busy intercity rail corridors. Railways around the world are now deploying driver advice systems developed by the research team and the partner organisation, TTG Transportation Technology. The project is designed to enable these systems to coordinate the movements ....Improving train flows with connected driver advice systems. The project aims to develop new train control theory to determine the efficient movement of multiple trains, and to demonstrate a practical system for coordinating trains, on busy intercity rail corridors. Railways around the world are now deploying driver advice systems developed by the research team and the partner organisation, TTG Transportation Technology. The project is designed to enable these systems to coordinate the movements of many trains on a congested rail network to improve timekeeping, smooth the flow of traffic, increase capacity and reduce energy use.Read moreRead less
Real-time scheduling of trains to control peak electricity demand. This project aims to develop new scheduling and control methods that will enable railways to reduce their demand for electricity during peak demand periods, without undue disruption to the timetable.
These new methods and systems will integrate with—and expand the capabilities of—an Australian train control system that is used by railways around the world. This will enable better management of electricity within a region and be ....Real-time scheduling of trains to control peak electricity demand. This project aims to develop new scheduling and control methods that will enable railways to reduce their demand for electricity during peak demand periods, without undue disruption to the timetable.
These new methods and systems will integrate with—and expand the capabilities of—an Australian train control system that is used by railways around the world. This will enable better management of electricity within a region and better use of renewable energy sources, with significant cost savings for railways and the wider community.Read moreRead less
Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 ....Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 billion pa in lost sales. This project will support the design of new infrastructure and processes to ensure an efficient supply chain. The new science resulting will benefit other coal operations in Australia, and potentially other bulk goods supply chains.Read moreRead less
Competitive supplier bidding in supply chains. This project will use mathematical modelling to contribute to better management practice in dealing with procurement. With the increasing use of auctions and sophisticated bidding procedures it is essential to improve our understanding of this important area.
Evaluating the long-term costs and benefits of community-based initiatives. The ultimate benefit from the research is a more efficient allocation of public funds to provide public services, i.e. an increase in the gain derived from the government budget. The relative advantages of alternative methods of delivering government services are subject to significant uncertainty, which means that policy decisions are often poorly informed. Improvements in the accuracy of predicting the costs and benefi ....Evaluating the long-term costs and benefits of community-based initiatives. The ultimate benefit from the research is a more efficient allocation of public funds to provide public services, i.e. an increase in the gain derived from the government budget. The relative advantages of alternative methods of delivering government services are subject to significant uncertainty, which means that policy decisions are often poorly informed. Improvements in the accuracy of predicting the costs and benefits of complex community-based initiatives will help policymakers identify the set of initiatives that provide the best outcomes for the community they serve, as well as informing the optimal specification of the individual initiatives.Read moreRead less
Maintenance Optimisation in Rail Infrastructure Systems for Coal and
Iron Ore Exports. Coal and iron ore exports, worth around 55 per cent of Australia's export earnings, critically depend on the transport capacity provided by Australia's rail infrastructure. Maintenance plays a crucial role in ensuring that infrastructure components are in a condition to provide safe, reliable, and efficient transport. However maintenance activities also reduce the system capacity, and are costly. It is thus c ....Maintenance Optimisation in Rail Infrastructure Systems for Coal and
Iron Ore Exports. Coal and iron ore exports, worth around 55 per cent of Australia's export earnings, critically depend on the transport capacity provided by Australia's rail infrastructure. Maintenance plays a crucial role in ensuring that infrastructure components are in a condition to provide safe, reliable, and efficient transport. However maintenance activities also reduce the system capacity, and are costly. It is thus critical to sustaining the growth and competitiveness of Australia's coal and iron ore exports that maintenance is optimised so as to maximise system efficiency and delivered capacity. The project aims to achieve this by the development of new decision support technologies embedding innovative decision-making models and algorithms.Read moreRead less