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A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Predictors And Correlates Of Health-related Quality Of Life And Morbidity In Overweight/obese Adolescents: Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$512,525.00
Summary
There is now no doubting the size and long-term risks to health of the childhood obesity epidemic. However, very little research has examined at population level its immediate consequences for mental health and physical functioning, what pathways confer risk and protection for these consequences, and their likely healthcare consequences. This study will utilise an existing cohort of approximately 1500 Victorian adolescents followed since childhood to examine neglected aspects of the genesis and ....There is now no doubting the size and long-term risks to health of the childhood obesity epidemic. However, very little research has examined at population level its immediate consequences for mental health and physical functioning, what pathways confer risk and protection for these consequences, and their likely healthcare consequences. This study will utilise an existing cohort of approximately 1500 Victorian adolescents followed since childhood to examine neglected aspects of the genesis and impacts of overweight and obesity. The Health of Young Victorians Study was originally assembled in 1997 when the children were in Grades Prep-3. In addition to information on putative risk and protective factors for overweight-obesity and direct measures of height and weight, it is unique in having collected data on health-related quality of life (HRQoL) since children were first recruited during the early primary school years. Eight years after the first wave, the children will be adolescents in Grades 8-11. This third wave will retain a focus on HRQoL. Innovations include study of potential emotional, behavioural and physical consequences of childhood obesity that may in turn affect the natural history of obesity. This large, population-based longitudinal study will redress neglected aspects of child and adolescent overweight-obesity specifically identified in 2003 by the NH and MRC. As well as establishing whether a range of common problems are related to overweight-obesity, it will be able to shed light on mechanisms of adverse outcomes associated with adolescent overweight-obesity, and study protective factors predicting remitting overweight from childhood to adolescence that may inform preventive activities. The study will make an international contribution to knowledge about pathways, prevalence and preventive opportunities for child and adolescent overweight-obesity.Read moreRead less
Activating employment futures through work integration social enterprise. This project aims to understand how Australia can better include people experiencing disadvantage in employment. Social enterprises are increasingly recognised for creating work and pathways into work for those who are typically excluded. Yet, little is known about how they can scale their operations and effectively transition workers into mainstream jobs, and what can be learned from social enterprise in designing other i ....Activating employment futures through work integration social enterprise. This project aims to understand how Australia can better include people experiencing disadvantage in employment. Social enterprises are increasingly recognised for creating work and pathways into work for those who are typically excluded. Yet, little is known about how they can scale their operations and effectively transition workers into mainstream jobs, and what can be learned from social enterprise in designing other inclusive workplaces. Underpinned by a unique learning partnership, this project is expected to shed light on how decent and inclusive work through social enterprise can be grown. Project insights will contribute to more effective employment services and workplaces that increase the shared benefits of a diverse workforce.Read moreRead less
Preventing Early Internalising Problems In The Preschool Setting: Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$893,870.00
Summary
Internalising mental health problems reflect inner emotional distress and encompass all symptoms of anxiety and depression. Affecting 1 in 7 Australian school-age children, many internalising problems persist into adulthood, impacting on personal wellbeing, family relations and workforce capabilities. This randomised prevention trial in the preschool-setting, screens for children at-risk and tests if a parenting program can reduce internalising problems across the population by school-entry.
Preventing Early Language Delay In Primary Care Setting:cluster Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$415,133.00
Summary
The trial aims to lower the numbers of children with poor expressive language skills at ages 2 and 3 years, through a sustainable early language promotion program linked to the universal Victorian Maternal and Child Health (M and CH) service, attended by more than 75% of Victorian children at 12 months of age. The trial targets the 20% of toddlers most at risk of expressive language delay, by virtue of having limited or no spoken vocabulary at 18 months of age. It also aims to lower the numbers ....The trial aims to lower the numbers of children with poor expressive language skills at ages 2 and 3 years, through a sustainable early language promotion program linked to the universal Victorian Maternal and Child Health (M and CH) service, attended by more than 75% of Victorian children at 12 months of age. The trial targets the 20% of toddlers most at risk of expressive language delay, by virtue of having limited or no spoken vocabulary at 18 months of age. It also aims to lower the numbers of children with behaviour problems (strongly linked to language delay), to determine the acceptability and cost-effectiveness of the approach, and to determine whether it differentially benefits disadvantaged children.Read moreRead less
Community efficiency: testing MacArthur’s minimisation principle for competitive communities. Robert MacArthur, one of the 20th century’s greatest ecologists, developed theory that had profound impacts on our understanding of island biogeography, species coexistence, and competition, yet one of his most powerful theoretical predictions, that competitive communities should become more efficient over time, has never been tested. A greater understanding of the dynamics of community efficiency will ....Community efficiency: testing MacArthur’s minimisation principle for competitive communities. Robert MacArthur, one of the 20th century’s greatest ecologists, developed theory that had profound impacts on our understanding of island biogeography, species coexistence, and competition, yet one of his most powerful theoretical predictions, that competitive communities should become more efficient over time, has never been tested. A greater understanding of the dynamics of community efficiency will provide profound insights into the role of that community in the broader ecosystem, as well as strong predictions about the invasibility and stability of that community. Read moreRead less
Adaptive ecotyping of the toxic cyanobacterium Cylindrospermopsis raciborskii to predict its invasive capacity. We change the world while other organisms adapt to these new conditions. Cyanobacteria (blue green algae) increasingly dominate water bodies that were previously free of these harmful blooms. To minimise the spread of these algae, this project will study the genetic basis that determines how rapidly they can evolve and adapt to a changing planet.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Activating lazy stormwater wetlands through real time monitoring & control. Constructed stormwater wetlands are the last line of defence preventing pollution of urban waterways, but wetlands often fail, with their passive operation unable to adapt to the highly variable climate and hydrology they experience. This project aims to use advances in real-time control technology to turn these lazy wetlands into active wetland systems, optimising their performance. It aims to deliver new-generation tec ....Activating lazy stormwater wetlands through real time monitoring & control. Constructed stormwater wetlands are the last line of defence preventing pollution of urban waterways, but wetlands often fail, with their passive operation unable to adapt to the highly variable climate and hydrology they experience. This project aims to use advances in real-time control technology to turn these lazy wetlands into active wetland systems, optimising their performance. It aims to deliver new-generation technologies to enhance water quality treatment, enhance urban water security and guarantee environmental flows to maintain healthy waterways. Working in partnership with waterway managers and water retailers, this project strives to deliver a nationally and globally relevant technology to change how we manage water in cities.Read moreRead less
A highly sensitive and selective nano-engineered sensor for the online monitoring of mercury vapour emissions from harsh industrial processes. The Australian alumina and aluminium industries contribute over $11 billion export income annually. All refineries, except one, operate in rural areas and are the main economic drivers in these regions. In order to maintain the industry's commitment to reduce the environmental impact of its processes and remain economically sustainable, innovative technol ....A highly sensitive and selective nano-engineered sensor for the online monitoring of mercury vapour emissions from harsh industrial processes. The Australian alumina and aluminium industries contribute over $11 billion export income annually. All refineries, except one, operate in rural areas and are the main economic drivers in these regions. In order to maintain the industry's commitment to reduce the environmental impact of its processes and remain economically sustainable, innovative technologies are required to monitor mercury emissions. The aim of this project is to develop robust sensors, for online monitoring of mercury vapours, that operate under challenging industrial environments. This project will also provide excellent training for young researchers in established international industrial research groups, thereby meeting skill shortages in the Australian resource sector.Read moreRead less