Modelling The Characteristics And Symptoms In First-episode Psychosis From Baseline To Long-term Follow-up
Funder
National Health and Medical Research Council
Funding Amount
$22,257.00
Summary
Relatively little is known about the progression of first-episode psychosis over the longer term. This research will investigate the course and evolution of psychiatric symptoms in over 600 psychotic patients up to 10 years following initial admission. It may be possible to identify groupings of patients with similar patterns of change in symptoms, along with factors underlying different patterns of symptom course, which may help distinguish the fundamental mechanisms underlying psychosis.
An Investigation Of Cortical Function In Autism Spectrum Disorders Using TMS, FMRI And EEG
Funder
National Health and Medical Research Council
Funding Amount
$324,480.00
Summary
Autism spectrum disorders (ASD) are severe psychiatric conditions, but our neurobiological understanding of these disorders is limited. Using an array of modern neuroscience techniques, this study investigates aspects of brain functioning that may contribute to social and behavioural impairments in ASD. While enhancing our neurobiological knowledge, this research also provides exciting new directions for ASD assessment and treatment.
The Effects Of Phencyclidine On The NMDA Receptor-neuregulin1 Signalling Complex: Implications For Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$433,872.00
Summary
Phencyclidine is the best known pharmacological agent that can induce schizophrenia-like symptoms in humans and animals. Recent research has strongly suggested that neuregulin1 and ErbB4 signalling are involved in schizophrenia pathology. This study will be the first to determine whether neuregulin1 is altered by phencyclidine, which will further our knowledge by re-evaluating the causal role of neuregulin1 in schizophrenia.
Abnormal Auditory System Function In Schizophrenia: An ERP And MEG Study Of Its Origin, Course And Generality.
Funder
National Health and Medical Research Council
Funding Amount
$250,770.00
Summary
In 1991, an Australian group found that schizophrenia patients have a reduced brain response to deviant sounds in a repeating pattern of identical sounds. Deviant sounds produce a brain electrical response known as mismatch negativity which is generated by the auditory cortex in the brain's temporal lobes and by adjacent areas in the frontal lobes. A smaller mismatch negativity in patients has since been replicated in laboratories in the US, Europe and Australia. The importance of this finding i ....In 1991, an Australian group found that schizophrenia patients have a reduced brain response to deviant sounds in a repeating pattern of identical sounds. Deviant sounds produce a brain electrical response known as mismatch negativity which is generated by the auditory cortex in the brain's temporal lobes and by adjacent areas in the frontal lobes. A smaller mismatch negativity in patients has since been replicated in laboratories in the US, Europe and Australia. The importance of this finding is that it had not been previously recognised that patients have low level auditory problems that could potentially have a profound impact on higher level functions. Finnish researchers have gone on to show in healthy individuals that mismatch negativity can reveal important features about how well the auditory system works, e.g., for the brain to respond to a deviant sound, it must have a memory of what happened in the past. Mismatch negativity provides a measure of the integrity of these memory functions. But it also provides an index of how well the auditory system discriminates different aspects of sound, pitch, loudness, and temporal features, such as duration. There are hints in our data and from US researchers that processing of the temporal features of sounds is particularly impaired in schizophrenia. We have also recently discovered that first-degree relatives of patients may have a similar deficit. The aim of this project is to use mismatch negativity to probe what is wrong with the auditory system in schizophrenia and those at risk (first degree relatives). Is it the areas of the brain primarily involved in sound perception (the temporal lobes) that are faulty or is the problem in the frontal lobes? Is it the case that processing of temporal features are particularly compromised and if so, is this a biological marker for schizophrenia. Answers to these questions will greatly enhance our understanding of the nature of the brain dysfunction in schizophrenia.Read moreRead less