Brain development during adolescence and the emergence of depression: A longitudinal MRI study. Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the inability to predict who is likely to go on to develop serious mental disorder. This study will provide critical information for und ....Brain development during adolescence and the emergence of depression: A longitudinal MRI study. Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the inability to predict who is likely to go on to develop serious mental disorder. This study will provide critical information for understanding the risk processes that are operating during the critical phase of early adolescence, and will therefore make a fundamental contribution to our understanding of who, and what, to target in early intervention and prevention strategies.Read moreRead less
Genes, neuroanatomy and family process: Predicting adolescent anxiety and depression. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the paucity of developmentally targeted treatment and prevention strategies. This study will provide unique information regarding the risk processes that are operating during early and late adolescence, and will inform us ....Genes, neuroanatomy and family process: Predicting adolescent anxiety and depression. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the paucity of developmentally targeted treatment and prevention strategies. This study will provide unique information regarding the risk processes that are operating during early and late adolescence, and will inform us about how the family environment can act to modulate the impacts of biological vulnerability on risk for mental disorder. This project will contribute to our understanding of who, and what, to target in early intervention and prevention strategies.Read moreRead less
The cognitive neuroscience of executive control: behavioural, physiological and genetic mechanisms. How genes influence our human abilities to think, reason and control behaviour has puzzled scientists for decades. The human genome project has allowed us to ask how individual genes influence these capacities. Understanding the genetics of these abilities provides a solid platform from which to launch gene discovery projects in clinical disorders where these abilities are compromised. The curr ....The cognitive neuroscience of executive control: behavioural, physiological and genetic mechanisms. How genes influence our human abilities to think, reason and control behaviour has puzzled scientists for decades. The human genome project has allowed us to ask how individual genes influence these capacities. Understanding the genetics of these abilities provides a solid platform from which to launch gene discovery projects in clinical disorders where these abilities are compromised. The current project is directly relevant to the genetics of mental disorders, such as attention deficit hyperactivity (ADHD), that place a large burden, both financially and emotionally, on our society. Understanding the genes and biological pathways that increase risk for mental disorders will ultimately lead to improved treatments for these conditions.Read moreRead less
The etiology of social anxiety and its impact on development across the lifespan. Social anxiety is a distressing early-onset disorder often associated with other psychiatric conditions in later life. This study will extend our previous work that has identified factors associated with its onset. We propose that these factors and the social anxiety itself may disrupt psychosocial development, at the time of onset, and throughout the lifespan. We aim to investigate these innovative hypotheses thro ....The etiology of social anxiety and its impact on development across the lifespan. Social anxiety is a distressing early-onset disorder often associated with other psychiatric conditions in later life. This study will extend our previous work that has identified factors associated with its onset. We propose that these factors and the social anxiety itself may disrupt psychosocial development, at the time of onset, and throughout the lifespan. We aim to investigate these innovative hypotheses through a sequence of three studies, with adults, children and adolescents. The results will inform prevention and early intervention regimes, thereby reducing both the incidence of social anxiety and the burden of the disorder.Read moreRead less
Health and resilience in the preschool years: An innovative approach to early intervention. Given the prevalence of psychopathology in childhood, it is essential that we maximise the effectiveness of early intervention (EI). Drawing on theory and research highlighting the marked influence, on cognitive and socio-emotional development, of particular kinds of parent-child discussions about past experiences, this project aims to foster preschooler's achievement of key developmental tasks (emergent ....Health and resilience in the preschool years: An innovative approach to early intervention. Given the prevalence of psychopathology in childhood, it is essential that we maximise the effectiveness of early intervention (EI). Drawing on theory and research highlighting the marked influence, on cognitive and socio-emotional development, of particular kinds of parent-child discussions about past experiences, this project aims to foster preschooler's achievement of key developmental tasks (emergent literacy, emotion knowledge, attachment) by training parents and children in effective conversational styles. The research will (i) develop an innovative, theoretically-driven approach to EI, (ii) test this approach in clinical and nonclinical populations, and (iii) provide a strong test of social interaction theories of development.Read moreRead less
Identifying risk markers for depression: A cognitive neuroscience approach. This project will establish objective markers for detecting early signs of depression. These markers are crucial in enabling early intervention to limit the course of depression. They will also benefit the development of prevention strategies, since they provide a means to identify high risk individuals. Currently there exists no simple and objective test or set of markers that can detect the early signs of depression. T ....Identifying risk markers for depression: A cognitive neuroscience approach. This project will establish objective markers for detecting early signs of depression. These markers are crucial in enabling early intervention to limit the course of depression. They will also benefit the development of prevention strategies, since they provide a means to identify high risk individuals. Currently there exists no simple and objective test or set of markers that can detect the early signs of depression. The available tests provide information relevant to the later-stage of clinical depression only. In this regard, non-invasive and objective markers are urgently required to limit the burden of depression. In Australia, $3.3 billion in productivity and 12 million working days are lost each year as a result of depression.Read moreRead less
Gene-brain pathways in emotional brain stability and instability. Emotional instability is a defining trait of major mental illnesses. The ability to identify individuals susceptible to emotional instability will be important in limiting the burden of disease from these illnesses. Mental conditions cost the Australian economy approximately $14.9 bill p/a, and depression will be the second leading contributor to burden of disease by 2020. The project will provide the first evidence for the combin ....Gene-brain pathways in emotional brain stability and instability. Emotional instability is a defining trait of major mental illnesses. The ability to identify individuals susceptible to emotional instability will be important in limiting the burden of disease from these illnesses. Mental conditions cost the Australian economy approximately $14.9 bill p/a, and depression will be the second leading contributor to burden of disease by 2020. The project will provide the first evidence for the combination of gene-brain-behaviour markers which best capture emotional instability versus resilience. This evidence base will be crucial to developing new tools and strategies for early intervention, and ultimately prevention, for these conditions of mental health.Read moreRead less
"Evidence based" evaluation of treatment in ADHD. Attention deficit hyperactivity disorder (ADHD) is marked by limitations in diagnostic accuracy, psychobiological characterisation and assessment of treatment efficacy. A national consortium of scientists and clinicians is planning to address these issues using an assessment protocol recently developed by the Brain Resource Company Ltd, which involves integrated neuroscientific and psychometric measurement that taps many of the brain's informati ...."Evidence based" evaluation of treatment in ADHD. Attention deficit hyperactivity disorder (ADHD) is marked by limitations in diagnostic accuracy, psychobiological characterisation and assessment of treatment efficacy. A national consortium of scientists and clinicians is planning to address these issues using an assessment protocol recently developed by the Brain Resource Company Ltd, which involves integrated neuroscientific and psychometric measurement that taps many of the brain's information processing networks. Specifically, the aims of the project are to identify biological and cognitive markers that reflect ADHD in its untreated form, and markers that discriminate treatment effects relative to the pre treatment profile. The results from this study will be translated into a product that uses the protocol to provide a service able to profile ADHD more accurately and evaluate the effects of treatment.Read moreRead less
The prevalence and cross-cultural comparison of daytime sleepiness in adolescents. International research shows many teenagers have problems falling asleep and being sleepy during the day. This can be due to an irregular sleep pattern of insufficient sleep on school nights, and sleeping-in on weekends. These problems lead to poor outcomes, including poor school performance and negative moods. The aims of the project are to measure the extent of sleep problems in Australian teenagers and compare ....The prevalence and cross-cultural comparison of daytime sleepiness in adolescents. International research shows many teenagers have problems falling asleep and being sleepy during the day. This can be due to an irregular sleep pattern of insufficient sleep on school nights, and sleeping-in on weekends. These problems lead to poor outcomes, including poor school performance and negative moods. The aims of the project are to measure the extent of sleep problems in Australian teenagers and compare these to adolescents in the United States. Detection of teenager sleep problems in Australia could lead to significant community awareness and school policy developments as it has in the United States. Read moreRead less
Risk factors for the development of paediatric anxiety disorders. Anxiety disorders are common and debilitating forms of disability affecting Australian children. This project blends strategic basic research with clinical application to advance our understanding of the causes of these disorders. By examining underlying child- and parent-based mechanisms by which children at greatest risk for these disorders transition to anxiety-disordered status, this project will lead to improved prevention an ....Risk factors for the development of paediatric anxiety disorders. Anxiety disorders are common and debilitating forms of disability affecting Australian children. This project blends strategic basic research with clinical application to advance our understanding of the causes of these disorders. By examining underlying child- and parent-based mechanisms by which children at greatest risk for these disorders transition to anxiety-disordered status, this project will lead to improved prevention and treatment strategies, which will improve the lives of affected children and their families and significantly reduce the financial burden on the Australian health care system.Read moreRead less