Linking arterial, brain and cognitive integrity in healthy older adults. This project aims to demonstrate that engaging the brain’s prefrontal cortex, an area that is highly sensitive to ageing, can improve the function of arteries that supply blood to this brain region. Using an innovative optical imaging methodology that maps the brain’s regional arterial health, it aims to generate new knowledge about the link between this arterial system and the progressive decline in cognitive control abili ....Linking arterial, brain and cognitive integrity in healthy older adults. This project aims to demonstrate that engaging the brain’s prefrontal cortex, an area that is highly sensitive to ageing, can improve the function of arteries that supply blood to this brain region. Using an innovative optical imaging methodology that maps the brain’s regional arterial health, it aims to generate new knowledge about the link between this arterial system and the progressive decline in cognitive control ability and in prefrontal cortex structure and function in healthy older adults. This interdisciplinary, international collaboration aims to put Australia at the forefront of brain optical imaging methods that may have significant benefits by informing approaches to promote and maintain healthy brain and cognition in old age.Read moreRead less
The elusive engram: What can infantile amnesia tell us about memory? Revealing the 'engram' is one of the greatest challenges neuroscience has faced. Substantial advances have been made in elucidating the mechanisms underlying memories that last for a few hours or days but much less is known about the cellular and molecular processes that mediate memories across remote periods of time. An underutilised approach to this problem is to study forgetting. The infant rat is an ideal model as they typi ....The elusive engram: What can infantile amnesia tell us about memory? Revealing the 'engram' is one of the greatest challenges neuroscience has faced. Substantial advances have been made in elucidating the mechanisms underlying memories that last for a few hours or days but much less is known about the cellular and molecular processes that mediate memories across remote periods of time. An underutilised approach to this problem is to study forgetting. The infant rat is an ideal model as they typically display good memory for a day or two but forget after a week or more. That is, they exhibit a specific impairment in the maintenance of remote memories. This project aims to determine the molecular/cellular processes underlying infantile amnesia and is expected to provide unique insights into memory processes in general.Read moreRead less
Effects of early life trauma on fear memory and fear extinction in rats. This project aims to increase our understanding of how early life stress affects fear regulation across development. The results will provide unique insights into normal developmental changes in fear regulation as well as abnormal developmental changes in these processes in those exposed to early life stress.
The future of childhood anxiety treatment: translating cognitive-neuroscience insights into clinical practice. The newest adult anxiety treatments use computer-based tasks that provide practice in overcoming maladaptive thinking patterns. This project is among the first to test this approach with children by developing a simple intervention that can be done at home. This new treatment will significantly reduce the burden of disease in Australia.
The role of early testosterone and brain laterality in language development. The aim of the project is to provide key insights into how foetal hormone exposure and early brain growth support child language. The specialisation of the left cerebral hemisphere for language function is considered critical to supporting the complexity of human language. There is evidence of sex differences in patterns of brain specialisation, which has led to popular but unsubstantiated hypotheses linking prenatal te ....The role of early testosterone and brain laterality in language development. The aim of the project is to provide key insights into how foetal hormone exposure and early brain growth support child language. The specialisation of the left cerebral hemisphere for language function is considered critical to supporting the complexity of human language. There is evidence of sex differences in patterns of brain specialisation, which has led to popular but unsubstantiated hypotheses linking prenatal testosterone and language development. The project aims to explore this by using innovative neuroimaging, endocrine and genetic techniques to track neurodevelopment longitudinally from prenatal life to three years of age. An important aspect of the project is the anticipated refinement of innovative methods for measuring early human development.Read moreRead less
Modelling trajectories of cognitive control in adolescents and young adults. This project aims to develop an innovative framework that models behaviour, brain function and brain structure to characterise developmental trajectories of cognitive control in typically-developing young people, and to test the model’s ability to predict psychosocial outcomes. Cognitive control processes are supported by complex frontal brain networks that develop well into adulthood. Poor cognitive control is linked t ....Modelling trajectories of cognitive control in adolescents and young adults. This project aims to develop an innovative framework that models behaviour, brain function and brain structure to characterise developmental trajectories of cognitive control in typically-developing young people, and to test the model’s ability to predict psychosocial outcomes. Cognitive control processes are supported by complex frontal brain networks that develop well into adulthood. Poor cognitive control is linked to negative psychosocial outcomes (e.g. substance use, high-risk behaviours). This work is expected to inform evidence-based programmes that identify young people at risk and develop targeted training strategies to improve psychosocial outcomes.Read moreRead less
Early puberty and brain development: exploring the neurobiology of adolescent mental health. Pubertal-onset mental disorders are the largest contributor to later adult mental disorders. However, compared to other phases of development, puberty and its disorders remain poorly understood. This study, by examining the neurobiological consequences of early exposure to puberty, will enhance our understanding of these pubertal risk processes.
The ageing brain: plasticity and training. This project will investigate how the capacity of a person's brain for reorganisation (plasticity) influences cognitive and motor function and training benefits in older adults. The findings will support new training initiatives to promote brain health and well-being across the lifespan.
Adjustment to retirement through social identity change. This project aims to improve our understanding of the factors governing successful adjustment to retirement. Retirement involves a major life change, to which 30 per cent of people fail to adjust successfully. Previous work in the social identity tradition suggests that the negative effects of significant life changes (eg moving into care) can be buffered by access to social group networks, but this possibility has not been examined in the ....Adjustment to retirement through social identity change. This project aims to improve our understanding of the factors governing successful adjustment to retirement. Retirement involves a major life change, to which 30 per cent of people fail to adjust successfully. Previous work in the social identity tradition suggests that the negative effects of significant life changes (eg moving into care) can be buffered by access to social group networks, but this possibility has not been examined in the context of retirement. This project plans to address this gap through studies that establish the importance of social group factors for successful adjustment among Australian, English, American and Chinese retirees. It also plans to test the efficacy of a new model that seeks to improve adjustment to retirement by incorporating various forms of social planning into preparation for this transition.Read moreRead less
Mapping the learning mechanisms linking adversity with maladjustment. Exposure to adversity, such as violence, neglect and natural disasters, is common and a powerful risk factor for emotional maladjustment. Yet knowledge of the underlying mechanisms linking adversity with emotional maladjustment is remarkably limited. By drawing from theories of adversity and learning and utilising novel experimental methodology, this project aims to map how adverse experiences have different negative effects o ....Mapping the learning mechanisms linking adversity with maladjustment. Exposure to adversity, such as violence, neglect and natural disasters, is common and a powerful risk factor for emotional maladjustment. Yet knowledge of the underlying mechanisms linking adversity with emotional maladjustment is remarkably limited. By drawing from theories of adversity and learning and utilising novel experimental methodology, this project aims to map how adverse experiences have different negative effects on daily emotional wellbeing by disrupting the mechanisms underlying how people learn to acquire and reduce reactivity to new threats. Expected benefits include new knowledge about the pathways linking adversity with psychopathology as well as the vital evidence-base for clear targets for behavioural interventions. Read moreRead less