Cognitive neuroscience of spatial asymmetry: behaviour, genes and brain imaging. When humans distribute their attention in space, biases or asymmetries of spatial attention exist. Healthy individuals exhibit a processing advantage favouring left space but this advantage is lost in disorders such as unilateral spatial neglect, ADHD and dyslexia. This project will develop novel electrophysiological methods to dissociate the sensory, attentional, decision-making and motoric contributions to spatial ....Cognitive neuroscience of spatial asymmetry: behaviour, genes and brain imaging. When humans distribute their attention in space, biases or asymmetries of spatial attention exist. Healthy individuals exhibit a processing advantage favouring left space but this advantage is lost in disorders such as unilateral spatial neglect, ADHD and dyslexia. This project will develop novel electrophysiological methods to dissociate the sensory, attentional, decision-making and motoric contributions to spatial asymmetries. By interfacing electrophysiology with genetic, neurochemical and brain imaging methods, this project will comprehensively map the biology of spatial asymmetry. This knowledge is vital to developing effective treatments for disorders where atypical patterns of spatial asymmetry index neurological vulnerability.Read moreRead less
Constructing a unified model of human memory. This project aims to systematically map the interplay between the episodic and semantic systems of memory across such functions as new learning, remembering the past, imagining the future and creative cognition. Memory is the cornerstone of adaptive functioning, yet models of human memory are incomplete. Episodic and semantic processes are typically treated as dissociable entities, despite mounting evidence of their interaction. Using experimental ta ....Constructing a unified model of human memory. This project aims to systematically map the interplay between the episodic and semantic systems of memory across such functions as new learning, remembering the past, imagining the future and creative cognition. Memory is the cornerstone of adaptive functioning, yet models of human memory are incomplete. Episodic and semantic processes are typically treated as dissociable entities, despite mounting evidence of their interaction. Using experimental tasks and advanced neuroimaging techniques in human lesion groups, this project will contribute data about the nature of episodic-semantic interactions. Expected outcomes include a refined model of human memory which will inform the capacity to optimise cognitive function.Read moreRead less
Placing prediction into the fear circuit. How do we predict danger in our world? This project will identify the psychological mechanisms and brain pathways that allow us to learn to fear and to also overcome fear when it becomes pathological.
Mapping, understanding and manipulating the human brain connectome with MRI. The human brain is an extraordinarily complex network, comprising millions of nerve cells connected by trillions of fibres. Understanding this intricate web of connectivity – the so-called human connectome – has become a central goal of neuroscience and is comparable in scale to the human genome project. This project will develop new brain imaging methods for accurately mapping the connectome. It will investigate how in ....Mapping, understanding and manipulating the human brain connectome with MRI. The human brain is an extraordinarily complex network, comprising millions of nerve cells connected by trillions of fibres. Understanding this intricate web of connectivity – the so-called human connectome – has become a central goal of neuroscience and is comparable in scale to the human genome project. This project will develop new brain imaging methods for accurately mapping the connectome. It will investigate how information is communicated between its different regions and how individual differences in brain network function relate to our genetic make-up. It will also determine whether we can manipulate the function of specific circuits of the connectome in a targeted way, in the hope of developing new treatments for brain disorders.Read moreRead less
Examining the neural mechanisms underlying cognitive control and its application to clinical syndromes featuring dyscontrol. This project will examine the cognitive control and its underlying neural mechanisms. Understanding this relationship is of major scientific interest because cognitive control dysfunction is related to a number of Australia's major social and economic problems, including drug dependence.
A new pathway to self-control: Testing a social-neurocognitive model of aggressive desires. One universal human desire is the urge to hurt another person when angry. This project aims to identify the psychological and neural mechanisms that will reduce the likelihood that people will experience the desire to hurt others when angered. Recent advances in self-regulation, have produced models sophisticated enough to develop and test predictions about how to stop harmful desires from arising.
The multitasking brain: training and individual differences. Difficulties with doing two things at once are experienced by everyone, but are particularly common as we get older and in the context of many neurological and psychiatric conditions. This project will examine how training changes the brain to improve multitasking performance and why some individuals are better at multitasking than others.
Testing theoretical models of age and disease related changes to inform prevention. Pathological brain changes associated with future cognitive decline become detectable in the 40s or earlier. Yet little is known about what constitutes normal brain ageing in mid-life. Using a number of neuroimaging and epidemiological techniques this project will scrutinise brain and cognitive ageing in middle-age and their significance.
Interpreting intrusions: Illuminating the cognitive mechanisms that fuel obsessional thought. This project aims to evaluate a theoretical model regarding the causal and maintaining role that cognitive biases play in obsessional thought. Obsessions are common in the general population and negatively impact health and daily functioning. Individuals struggle with their obsessions but are unable to disengage from them. A pressing question is: what makes an obsession so “sticky”? To answer this quest ....Interpreting intrusions: Illuminating the cognitive mechanisms that fuel obsessional thought. This project aims to evaluate a theoretical model regarding the causal and maintaining role that cognitive biases play in obsessional thought. Obsessions are common in the general population and negatively impact health and daily functioning. Individuals struggle with their obsessions but are unable to disengage from them. A pressing question is: what makes an obsession so “sticky”? To answer this question, this project aims to employ a novel, computerised experimental methodology to directly manipulate cognitive processes proposed to underpin obsessions. This methodology will be used to alter key biases proposed to drive obsessional thinking, thus shedding light on core psychological mechanisms.Read moreRead less
Understanding genetic and environmental risks of emotional disorders in childhood and adolescence. To reduce the burden of mental health disorders in Australia, this project will advance knowledge on genetic and environmental causes of anxiety and related disorders in children and adolescents. The results will allow better identification of children at risk for emotional problems and will identify new ways of tailoring prevention and treatment.