Fake News and Post-Truth Impacts: Responses to Conflictive Uncertainty. Attributions of fake news and post-truth are symptoms of uncertainty arising from conflicting information. Little is known about human responses to conflictive uncertainty other than that people find it aversive. This project aims to identify the determinants of human attitudes towards conflictive uncertainty. The aims will be achieved via the development of measures of attitudes toward conflictive uncertainty, and studies i ....Fake News and Post-Truth Impacts: Responses to Conflictive Uncertainty. Attributions of fake news and post-truth are symptoms of uncertainty arising from conflicting information. Little is known about human responses to conflictive uncertainty other than that people find it aversive. This project aims to identify the determinants of human attitudes towards conflictive uncertainty. The aims will be achieved via the development of measures of attitudes toward conflictive uncertainty, and studies identifying the major influences thereof. Expected outcomes include advances in knowledge of how conflictive uncertainty attitudes relate to risk orientations, personality, and situational factors. Anticipated benefits include improved strategies for decision makers and communicators faced with conflictive uncertainty.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100015
Funder
Australian Research Council
Funding Amount
$400,996.00
Summary
Understanding attitudes toward ambiguity: A multidimensional framework. This project aims to develop a comprehensive psychological framework and effective measures for assessing attitudes to ambiguity. Using empirical work and quantitative modelling, it will address the multidimensional nature of ambiguity, and likely individual and cultural differences. Attitudes to ambiguity strongly influence people's judgments and the expected outcomes from this project will enhance theoretical understandin ....Understanding attitudes toward ambiguity: A multidimensional framework. This project aims to develop a comprehensive psychological framework and effective measures for assessing attitudes to ambiguity. Using empirical work and quantitative modelling, it will address the multidimensional nature of ambiguity, and likely individual and cultural differences. Attitudes to ambiguity strongly influence people's judgments and the expected outcomes from this project will enhance theoretical understandings and measurement tools for psychological research in decision making. This project aims to provide significant benefits by developing novel strategies for improving decision making in contexts of ambiguity.Read moreRead less
Emotions and Employee Turnover: New Methods for Complex Dynamic Systems. This project aims to vastly improve the data-analytic capabilities of social and health researchers, while increasing knowledge about emotion dynamics and their link to employee turnover. By drawing on and advancing methods from ecology and applied physics, this project plans to investigate the role that individual emotions play in employee turnover with new quantitative methods for characterising and testing causality in c ....Emotions and Employee Turnover: New Methods for Complex Dynamic Systems. This project aims to vastly improve the data-analytic capabilities of social and health researchers, while increasing knowledge about emotion dynamics and their link to employee turnover. By drawing on and advancing methods from ecology and applied physics, this project plans to investigate the role that individual emotions play in employee turnover with new quantitative methods for characterising and testing causality in complex dynamic systems. The expected outcomes include an improved capacity for researchers, managers, and policy makers to understand complex organisational, economic, and health systems. This will provide immediate societal benefits by informing the development and deployment of targeted interventions in such systems.Read moreRead less
Judgements and Decisions under Ambiguity and Conflict. Little is known about how people make decisions when faced with uncertainties arising from information that is both ambiguous and conflicting, despite the fact that ambiguity and conflict frequently arise in real decision-making situations. In fact, virtually nothing is known about the joint impact of conflict and ambiguity on judgements of risk and uncertainty or on decisional preferences. This project will investigate how perceptions of un ....Judgements and Decisions under Ambiguity and Conflict. Little is known about how people make decisions when faced with uncertainties arising from information that is both ambiguous and conflicting, despite the fact that ambiguity and conflict frequently arise in real decision-making situations. In fact, virtually nothing is known about the joint impact of conflict and ambiguity on judgements of risk and uncertainty or on decisional preferences. This project will investigate how perceptions of uncertainty are jointly affected by conflict and ambiguity in information, develop and test formal models of judgement and decision making under conflict and ambiguity, and examine the joint effects of ambiguity and conflict aversion on decision making.Read moreRead less
Role Of Transition Metal Ions And Redox Activity In The Development Of Atherosclerotic Plaques
Funder
National Health and Medical Research Council
Funding Amount
$196,018.00
Summary
Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability ....Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability to generate free radicals is controversial. This study will employ a novel, minimally-invasive, technique to assess the nature and quantity of metal ions present in well-defined human and animal lesions at different stages of lesion development. The ability of these metal ions to catalyse free radical formation from components present in the artery wall will also be assessed. The release of these metal ions from the artery wall to added organic molecules will be assessed as this might minimise their potential to cause damage, and provide a possible therapeutic strategy. These studies will therefore provide valuable information as to the significance and role of reactive metal ions in the development of human artery disease and the possible prevention, or minimisation, of such processes.Read moreRead less
Zero-sum thinking: psychological predictors and causes. This project investigates the causes and psychological triggers of zero-sum thinking, the tendency to think that others' gains leave less for oneself. The results will enable negotiators and managers to defuse dysfunctional zero-sum thinking, thereby increasing the chances for cooperation and 'win-win' outcomes.
Mitochondrial Iron Overload And Friedreich's Ataxia: The Role Of Frataxin In Iron And Haem Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$606,000.00
Summary
Friedreich's ataxia (FA) is due to the lack of a protein known as frataxin. A variety of studies using Baker's yeast and conditional frataxin knockout (KO) mice have shown that deletion of frataxin leads to the accumulation of toxic iron in their mitochondrion. More recently, a variety of studies have shown that FA patients have iron-loading within their mitochondrion. Iron in the highly redox active environment of the mitochondrion could contribute to the generation of cytotoxic radicals that c ....Friedreich's ataxia (FA) is due to the lack of a protein known as frataxin. A variety of studies using Baker's yeast and conditional frataxin knockout (KO) mice have shown that deletion of frataxin leads to the accumulation of toxic iron in their mitochondrion. More recently, a variety of studies have shown that FA patients have iron-loading within their mitochondrion. Iron in the highly redox active environment of the mitochondrion could contribute to the generation of cytotoxic radicals that cause severe damage. Further, cells deficient in frataxin are sensitive to oxidant stress and Fe chelators rescue oxidant-mediated death of cells from FA patients. Indeed, free radical scavengers have shown to be of use in the treatment of this disease. Studies in DR's lab during this NHMRC grant have shown that frataxin is down-regulated by erythroid differentiation or the haem precursor, protoporphyrin IX (BLOOD 2002;99:3813-22). These data indicate a role for frataxin in Fe metabolism and the pathogenesis of FA. In this study we will continue to examine the role of frataxin in the way cells handle Fe using experimental models developed under the current NHMRC grant. These include transfected cell lines with low frataxin expression generated using an expression vector containing anti-sense frataxin cDNA. Further we obtained the frataxin conditional KO mouse and generated a breeding colony. These animals display many of the pathological features of FA and are the best current model of the disease. Indeed, they will be critical for assessing the role of frataxin in Fe metabolism and as a model to test the ability of Fe-binding drugs to prevent the pathology observed. We designed lipid-soluble chelators that can enter the mitochondrion to bind Fe (Biochim Biophys Acta 2001;1536:133-140) and these ligands will be tested to prevent disease progression in the KO mice. This exciting research is crucial for understanding the pathogenesis of FA and in creating new therapies.Read moreRead less
Adolescent Gambling: Prevalence, Risk Factors, and Opportunities for Controls and Interventions. This research will contribute to both scientific knowledge and public policy in an area of considerable public concern. It will measure the prevalence of gambling among adolescents in the ACT, and identify the proportion of youth with actual or potential gambling problems. It will assess their degree of exposure to gambling advertising and their awareness of services for young problem gamblers. The p ....Adolescent Gambling: Prevalence, Risk Factors, and Opportunities for Controls and Interventions. This research will contribute to both scientific knowledge and public policy in an area of considerable public concern. It will measure the prevalence of gambling among adolescents in the ACT, and identify the proportion of youth with actual or potential gambling problems. It will assess their degree of exposure to gambling advertising and their awareness of services for young problem gamblers. The project will also identify risk factors for problem gambling, and protective factors and policy opportunities for the reduction of problem gambling. It will also contribute to methodological knowledge by assessing the validity of multiple measures of problem gambling.Read moreRead less