A Randomised Controlled Trial Of A Mindfulness Intervention For Men With Advanced Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$729,841.00
Summary
Approximately 22,000 Australian men alive today have advanced prostate cancer. By comparison to men with localised prostate cancer, men with advanced disease report higher levels of psychological distress and poorer quality of life, and have an increased risk of suicide. This study will trial a remote access mindfulness-based cognitive therapy intervention aimed at improving mental health outcomes and wellbeing for men with advanced prostate cancer.
Step Up: A Technology-enhanced Stepped Psychological Intervention For Strengthening Adaptive Capacity And Treating Post-traumatic Comorbidities In Refugees
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
There is a major translational gap in rolling out psychotherapeutic treatments into readily accessible public health interventions for refugees. This project examines the feasibility and effectiveness of a technology-enhanced stepped psychological intervention designed to build resilience (Step 1) and manage traumatic stress symptoms and related comorbidities in traumatized refugees to ensure they have an enhanced capacity to adapt to the new environment post trauma.
Single-focussed Versus Integrated Cognitive Behaviour Therapy For Co-occurring Depression And Alcohol Use Problems
Funder
National Health and Medical Research Council
Funding Amount
$777,500.00
Summary
This study is significant and timely in that it proposes a large-scale randomised controlled trial of cognitive behaviour therapy (CBT) for people with co-occurring depression and alcohol use problems. To date, very few researchers have conducted research within this population, whose complex presentation makes it difficult for treatment providers to select and deliver effective treatment programs. Thus, although rates of depressive disorders and alcohol use problems are on the increase in our c ....This study is significant and timely in that it proposes a large-scale randomised controlled trial of cognitive behaviour therapy (CBT) for people with co-occurring depression and alcohol use problems. To date, very few researchers have conducted research within this population, whose complex presentation makes it difficult for treatment providers to select and deliver effective treatment programs. Thus, although rates of depressive disorders and alcohol use problems are on the increase in our community, it is still not clear how best to manage and treat this group of people. Typically, people will often receive treatment for one part of their presentation, for example their depression or alcohol use problem. However, it is uncommon for the two conditions to be treated in an integrated way. This is certainly true for psychological treatments. Research programs to date have explored effective treatments for depression and alcohol use in the absence of the co-occurring condition. Currently it is not known how well people with co-occurring alcohol use problems and depression respond to treatments with a singular focus. Furthermore, it is not known whether integrating both alcohol use and depressive treatment approaches provides any additional benefit. This study is therefore significant, as it is one of the first to explore effective treatment approaches among people with co-occurring depressive and alcohol use problems. Resolution of these issues will better inform the treatment choices of clinicians practicing in both mental health and alcohol-other drug settings. Importantly, this will potentially improve the match between treatment and people with depression and substance use problems, a clinically prevalent population encountered in community settings.Read moreRead less
Depression Prevalence: Delineation Issues In 2007 National Mental Health & Wellbeing And 2008 South Australian Surveys
Funder
National Health and Medical Research Council
Funding Amount
$257,051.00
Summary
It is believed depression is increasing and Australia has many health interventions to help, but it is unknown if these are reducing depression prevalence. Two surveys have reported on depression in the past 10 years. One shows it is decreasing, the other it is increasing. This study will examine depression measurement in both surveys to find out why they disagree. The findings will have implications for future depression measurement and what health care interventions should be planned.
Living In A Rural Community:determinants And Consequences Of Mental Health And Wellbeing.
Funder
National Health and Medical Research Council
Funding Amount
$729,415.00
Summary
Th e proposed study will investigate individual, family and community factors associated with the mental health and wellbeing of residents in rural communties of NSW. It will also examine rural residents' perceptions of their mental health needs and their access and utilisation of health services. The study will be conducted in 3 rural Area Health Services in NSW (Greater Western,Hunter New England and North Coast) comprising 70% of the rural population of NSW. These health regions encompass rur ....Th e proposed study will investigate individual, family and community factors associated with the mental health and wellbeing of residents in rural communties of NSW. It will also examine rural residents' perceptions of their mental health needs and their access and utilisation of health services. The study will be conducted in 3 rural Area Health Services in NSW (Greater Western,Hunter New England and North Coast) comprising 70% of the rural population of NSW. These health regions encompass rural, remote and coastal NSW. We aim to conduct the mail and telephone survey on adults residing in 4000 households across the 3 regions. Unique aspects of the study include: i) Examination of a diverse range of rural communities which will provide the opportunity to investigate the influence and interaction of specific community characteristics on mental health. These community factors will include social and economic factors, severity of rural environmental stress (eg drought), and the levels of access to health and other services. ii) Focus on the household and its members so as to examine the mental health needs of family groups in rural communities. This cross-sectional study will form the baseline for a longitudinal study investigating the changes experienced by rural families over time and the impact of such change on mental health outcomes.Read moreRead less
The Efficacy Of Behavioural Activation Therapy In Treating Depression Among Individuals With Opioid Dependence
Funder
National Health and Medical Research Council
Funding Amount
$733,908.00
Summary
Heroin dependence is a chronic relapsing condition, associated with high levels of psychopathology. On entry to treatment at least one quarter of heroin users meet criteria for Major Depression. The co-occurrence of heroin dependence and depression is associated with a range of harms and has been linked to poorer treatment outcomes. Despite this, practical and effective treatment options are scarce. The proposed international collaboration will contribute significantly to understanding of the tr ....Heroin dependence is a chronic relapsing condition, associated with high levels of psychopathology. On entry to treatment at least one quarter of heroin users meet criteria for Major Depression. The co-occurrence of heroin dependence and depression is associated with a range of harms and has been linked to poorer treatment outcomes. Despite this, practical and effective treatment options are scarce. The proposed international collaboration will contribute significantly to understanding of the treatment of this comorbidity.Read moreRead less
Does Inpatient Weight Restoration Prior To Outpatient Family Therapy Improve Outcomes In Adolescent Anorexia Nervosa?
Funder
National Health and Medical Research Council
Funding Amount
$552,283.00
Summary
This study examines the effect of length of hospital admission for refeeding, prior to manualised outpatient family therapy on outcomes for patients with anorexia nervosa. Subjects will include sixty children and adolescents aged 10 to 18 years admitted to the Children's Hospital at Westmead for medical management of anorexia nervosa. This study aims to randomly allocate and compare outcomes between adolescents with anorexia nervosa admitted for medical stabilisation followed by outpatient famil ....This study examines the effect of length of hospital admission for refeeding, prior to manualised outpatient family therapy on outcomes for patients with anorexia nervosa. Subjects will include sixty children and adolescents aged 10 to 18 years admitted to the Children's Hospital at Westmead for medical management of anorexia nervosa. This study aims to randomly allocate and compare outcomes between adolescents with anorexia nervosa admitted for medical stabilisation followed by outpatient family therapy versus adolescents admitted for full weight restoration followed by outpatient family therapy. Physical and psychological outcomes will be measured at admission to hospital, at the end of the hospital treatment and at the completion of outpatient family therapy and 6 and 12 months after the completion of treatment.Read moreRead less
Wernicke-Korsakoff syndrome is a common and frequently undiagnosed neurological disease due to thiamine deficiency. The condition leads to cognitive and neurological disability and mostly affects people with alcohol dependence. Wernicke-Korsakoff syndrome is eminently treatable with thiamine, although we have insufficient knowledge regarding the best dose of thiamine to treat the condition. This project proposes two controlled trials to evaluate treatment effectiveness of thiamine for Wernicke-K ....Wernicke-Korsakoff syndrome is a common and frequently undiagnosed neurological disease due to thiamine deficiency. The condition leads to cognitive and neurological disability and mostly affects people with alcohol dependence. Wernicke-Korsakoff syndrome is eminently treatable with thiamine, although we have insufficient knowledge regarding the best dose of thiamine to treat the condition. This project proposes two controlled trials to evaluate treatment effectiveness of thiamine for Wernicke-Korsakoff syndrome.Read moreRead less
Integrating Treatment For Alcohol Use Problems And Comorbid PTSD
Funder
National Health and Medical Research Council
Funding Amount
$658,073.00
Summary
Comorbid alcohol use problems and posttraumatic stress disorder (PTSD) are common mental health problems that cause disability and distress. Despite this, there are few randomized controlled trials of interventions. The proposed study is the first Australian randomised controlled trial in this field to address the question of whether treating PTSD and alcohol use problems is superior to treating alcohol use problems alone. The study compares the relative efficacy of a manual guided treatment for ....Comorbid alcohol use problems and posttraumatic stress disorder (PTSD) are common mental health problems that cause disability and distress. Despite this, there are few randomized controlled trials of interventions. The proposed study is the first Australian randomised controlled trial in this field to address the question of whether treating PTSD and alcohol use problems is superior to treating alcohol use problems alone. The study compares the relative efficacy of a manual guided treatment for alcohol use disorder alone with a simultaneous treatment for alcohol use and PTSD. This study improves on the methodological limitations described in the two existing studies reported in the published literature. Two-hundred and sixty four participants will be recruited from mutiple sites (media, GPs, specialist clinics) and treated in the community at two sites in Sydney. Participants will be eligible if they consume harmful levels of alcohol (NHMRC risky or high risk levels) and have a concurrent diagnosis of PTSD based on recognised diagnostic criteria. Treatment will consist of 16 sessions of manual guided individual psychological therapy that has been found to be very efficacious with each problem alone. The efficacy of treatment will be determined on the basis of reductions in harmful drinking (above NHMRC low risk levels) and in symptoms of PTSD. Participants will be followed up by an independent, blind, clinician three and six months after treatment completion. The findings of this study have the potential to provide valuable information regarding the treatment needs of people with these complex presentations to clinicians and policy developers alike.Read moreRead less