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Deakin Family Options: engaging youth with high prevalence mental health problems using family based interventions. Youth depression, anxiety and substance abuse are prevalent, distressing and costly problems impacting one in five young Australians. This collaborative project - called ‘Deakin Family Options’ - will evaluate a family based intervention in order to broaden the therapeutic approaches used for young people and their families.
Plasma protein profiles in normal brain ageing and early stages of dementia. Brain changes related to ageing and dementia are associated with altered proteins that can be detected in the blood. This project will examine blood samples from a number of well-characterised ageing cohorts to discover proteins that may serve as potential markers of brain ageing and the early stages of dementia.
Bereavement of suicide and sudden death. Losing someone to suicide can have devastating affects on the survivors left behind. The aims of the present study include the identification of the processes and impacts of bereavement on survivors in various age groups. It also aims to identify critical points during the bereavement and factors which exacerbate and moderate negative impacts. This has been previously neglected in suicide research in Australia and its findings will add a multi-dimensional ....Bereavement of suicide and sudden death. Losing someone to suicide can have devastating affects on the survivors left behind. The aims of the present study include the identification of the processes and impacts of bereavement on survivors in various age groups. It also aims to identify critical points during the bereavement and factors which exacerbate and moderate negative impacts. This has been previously neglected in suicide research in Australia and its findings will add a multi-dimensional aspect to postvention not currently understood. It is expected that findings will help develop guidelines to ensure more effective detection and intervention for survivors, as well as enhancing social support and personal resilience.Read moreRead less
Mindfulness and coping in chronic illness: insights from a study of joint replacement surgery. This study investigates whether participation in a mental health enhancement program (mindfulness) will improve the recovery of patients undergoing total joint replacement. This will benefit patients by promoting psychological well-being which has direct effects on pain and physical function after surgery.
Poor social functioning in schizophrenia: understanding its causes and developing better treatments. This project will advance knowledge of the thinking processes and the associated neural changes that cause the lifelong social disability which characterises schizophrenia. Findings will, in turn, contribute to better identifying young people, at risk of developing schizophrenia, and inform the design of new interventions and treatments.
Moral reasoning and mental illness: towards a model of moral judgment and moral accountability. This research examines capacities for moral judgment in people with schizophrenia, some of whom act on their delusional beliefs and commit crimes. Findings will, in turn, inform legal and philosophical consideration of the moral accountability of mentally ill defendants, and advance theoretical knowledge of healthy moral decision making.
The electrophysiological signature of inner speech. This project aims to develop an objective neurophysiological marker that identifies when a person is talking silently to themselves in their head (inner speech), and what they are saying internally. Such a marker would be an important development in the field of cognitive science. It could reveal the fundamental nature of inner speech (whether inner speech is actually a special form of overt speech), and lead to ‘brain-computer interface’ techn ....The electrophysiological signature of inner speech. This project aims to develop an objective neurophysiological marker that identifies when a person is talking silently to themselves in their head (inner speech), and what they are saying internally. Such a marker would be an important development in the field of cognitive science. It could reveal the fundamental nature of inner speech (whether inner speech is actually a special form of overt speech), and lead to ‘brain-computer interface’ technologies that can decipher inner speech and communicate it with the outside world.Read moreRead less
Music as bridge between strengths and difficulties: preventing mental ill-health through early identification and early intervention in adolescence. The World Health Organisation and the Australian Government both predict an alarming rise in chronic mental health problems. In this study, an innovative, musically derived strengths and difficulties assessment tool will be developed and validated to facilitate the early identification of, and early intervention with at risk young people.
Cannabis and the brain: the good, the bad and the unknown. Cannabis is the most widely used illicit drug but much remains unknown about how it affects the brain. This research will examine effects on brain cells through to whole brain function in humans to determine how cannabis use may lead to impaired thinking or psychological symptoms and why cannabis might affect individuals in different ways.
Evaluation And Improvement Of The Implementation Of The Intention To Treat Model In Controlled Trials Of Psychotherapies
Funder
National Health and Medical Research Council
Funding Amount
$409,000.00
Summary
Randomized controlled trials (RCTs) are the best way to determine whether patients benefit from a new treatment. In these trials patients are randomly assigned to the new, active treatment, or to a placebo or existing treatment. The groups are compared at the end of the trial. RCTs may be mounted for psychotherapy and educational programs as well as for new drugs and other medical procedures. A major problem for RCTs concerns their statistical analysis when some participants drop out before the ....Randomized controlled trials (RCTs) are the best way to determine whether patients benefit from a new treatment. In these trials patients are randomly assigned to the new, active treatment, or to a placebo or existing treatment. The groups are compared at the end of the trial. RCTs may be mounted for psychotherapy and educational programs as well as for new drugs and other medical procedures. A major problem for RCTs concerns their statistical analysis when some participants drop out before the end of the trial. Dropout is common in trials. Participants may drop out because they feel no benefit from the treatment, dislike side effects, or even because they have recovered quickly. Thus, to compare the groups remaining at the end of trial may introduce serious bias. The Intention to Treat (ITT) principle which has been widely adopted states that outcomes from all patients who enter a trial should be compared at its end. To achieve this, the last available observation for a participant who withdraws is often 'carried forward' to the end of the trial. While currently believed to be conservative, there is evidence that this approach is not always optimal. This project will examine the way in which dropout is treated in trials of two common psychiatric conditions: depression and anxiety disorders. The project will also undertake simulation research to investigate which of a number of modern methods of data analysis yield the most accurate results when participants drop out, and how changes in the design of trials might improve accuracy. The project is important because it will enable researchers to improve the conduct of trials in the future. Erroneous conclusions drawn from RCTs stand to condemn those suffering from disorders to ineffective treatment and to lead to the premature abandonment of potentially useful interventions which are falsely claimed to lack efficacy.Read moreRead less