Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes impor ....Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes important for programming the identity of cells that comprise our blood vessels, lymphatic vessels and circulating blood cells.
Benefits: Data generated will underpin the development of approaches to program/reprogram stem cells to produce mature cells for transplantation or tissue engineering purposes ex vivo.Read moreRead less
Improved cryopreservation protocols for long term storage of platelets. The aim of this project is to characterise human blood platelet deterioration during cold storage and cryopreservation, and accelerate the development of improved long-term storage options. The project expects to generate important new knowledge about how platelets deteriorate during storage, and how such deterioration can be minimized. The expected outcomes are improved methods for long term platelet storage. This should be ....Improved cryopreservation protocols for long term storage of platelets. The aim of this project is to characterise human blood platelet deterioration during cold storage and cryopreservation, and accelerate the development of improved long-term storage options. The project expects to generate important new knowledge about how platelets deteriorate during storage, and how such deterioration can be minimized. The expected outcomes are improved methods for long term platelet storage. This should benefit blood donation services and hospitals by improving platelet delivery to remote locations, reducing wasted blood and the number of donations required, leading to significant financial savings.Read moreRead less