Determinants And Impact Of Patient-Centred Health Outcomes In Psoriatic Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$84,069.00
Summary
Psoriatic arthritis is a chronic joint disease which is linked with the skin condition called psoriasis. People who have psoriatic arthritis can develop deformities in their joints and suffer from decreased quality of life. Psoriatic arthritis can present in a wide range of ways, but the reasons for this are not understood. This research aims to explain some of this variation and to predict which patients will develop more severe disease so treatment can be targeted to improve their outcome.
Molecular Targeting Of Innate Immune Signalling Pathways In Cancer And Auto-Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
To achieve an accurate molecular understanding of innate immune system receptor signalling, both intracellularly and in whole organisms, in health and disease. This knowledge will then be used to generate better treatments for the extensive range of human diseases that are caused or exacerbated by dysfunctional innate immune signalling, including Crohn's disease, psoriasis and cancer.
This application describes a research proposal that will achieve an accurate molecular understanding of innate immune system receptor signalling in health and disease. This knowledge will then be used to generate better treatments for the extensive range of human diseases that are caused or exacerbated by dysfunctional innate immune signalling, including Crohn's disease, psoriasis and cancer.
Many products are applied to the skin to prevent skin cancer or to treat skin diseases. This project seeks to better understand how we can make such products more affective, safer and appropriate for conditions such as psoriasis. One major component of the grant is concerned with the evaluation of nanotechnology products applied to the skin.
Expanding The Repertoire Of Immunomodulatory Drugs: Targeting The Melanocortin System Using Engineered Cyclic Peptides
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Autoimmune diseases, including rheumatoid arthritis and psoriasis, have profound impacts on the lives of many Australians. New drugs are required for these diseases as existing treatments are expensive, become less effective with repeated use or cause adverse side effects. My project will work towards addressing this need by investigating the potential of ultrastable cyclic miniproteins as scaffolds for displaying bioactive peptides that are known to restore immune self-tolerance.
Regulatory Interactions Between YAP And Beta-catenin In Normal Epidermal Homeostasis And In Skin Cancer
Funder
National Health and Medical Research Council
Funding Amount
$396,157.00
Summary
Australia has the highest skin cancer incidence in the world. We found that oncoprotein YAP activates stem cell proliferation in the skin through activation of the Wnt pathway, and we have evidence that YAP is hyperactivated in human skin cancer. We will map out the molecular nature of the interaction between YAP and the Wnt pathway in normal epidermal homeostasis and in skin cancer. This study will provide novel insights for development of therapeutic avenues for human skin cancer and other reg ....Australia has the highest skin cancer incidence in the world. We found that oncoprotein YAP activates stem cell proliferation in the skin through activation of the Wnt pathway, and we have evidence that YAP is hyperactivated in human skin cancer. We will map out the molecular nature of the interaction between YAP and the Wnt pathway in normal epidermal homeostasis and in skin cancer. This study will provide novel insights for development of therapeutic avenues for human skin cancer and other regenerative dermatological disorders.Read moreRead less