Modulating T cell responses with novel Lck activating compounds. Modulating T cell responses with novel Lck activating compounds. This project aims to research T cell receptor (TCR) signal initiation and network plasticity and identify uses for drugs that affect the kinase Lck. The TCR signalling network has considerable plasticity so that modulation of one molecule (here the drug target is Lck) can have non-linear effects on T cell function. This project intends to use novel drugs to understand ....Modulating T cell responses with novel Lck activating compounds. Modulating T cell responses with novel Lck activating compounds. This project aims to research T cell receptor (TCR) signal initiation and network plasticity and identify uses for drugs that affect the kinase Lck. The TCR signalling network has considerable plasticity so that modulation of one molecule (here the drug target is Lck) can have non-linear effects on T cell function. This project intends to use novel drugs to understand how the T cell network can be exploited to control both the magnitude and quality of the T cell responses. This research is expected to aid the design of immune-modulating drugs.Read moreRead less
Expression and substrate recognition by MARCH ubiquitin ligases. Eukaryotic cells are compartmentalised, with different organelles playing distinct functions. This project will characterise the MARCHs, proteins which control the localisation and half-life of other proteins. Understanding how the MARCHs work will provide novel insights into fundamental cellular processes that play major roles in many biological functions.
Moonlighting from sugar to metal. This project intends to use integrated genetics, biochemistry and omics to decipher the roles of the highly conserved OST3 proteins, which have been implicated in the disparate functions of regulating protein glycosylation and transporting magnesium. The project plans to detail the role of OST3 proteins in regulating mammalian glycosylation and reconstruct the vertebrate co-evolutionary trajectory of OST3 protein–substrate interactions. It also aims to identify ....Moonlighting from sugar to metal. This project intends to use integrated genetics, biochemistry and omics to decipher the roles of the highly conserved OST3 proteins, which have been implicated in the disparate functions of regulating protein glycosylation and transporting magnesium. The project plans to detail the role of OST3 proteins in regulating mammalian glycosylation and reconstruct the vertebrate co-evolutionary trajectory of OST3 protein–substrate interactions. It also aims to identify and characterise the regulation, mechanisms and metabolic consequences of OST3 protein-mediated magnesium transport. These outcomes may provide insights into eukaryotic biology, and allow advances in engineered systems for glycoprotein production and modulating cellular metabolism with potential research and therapeutic utility.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101479
Funder
Australian Research Council
Funding Amount
$450,948.00
Summary
The investigation of an unconventional Human Leukocyte Antigen molecule. This project aims to characterise a unique and understudied surface molecule (HLA-E). The immune system is activated and regulated by a complex set of molecules including HLA molecules present on the cell surface that inform the immune system of infection. Therefore, this project expects to generate new knowledge in the areas of cellular biology and immunology by utilising a cutting-edge and multi-disciplinary approach. Exp ....The investigation of an unconventional Human Leukocyte Antigen molecule. This project aims to characterise a unique and understudied surface molecule (HLA-E). The immune system is activated and regulated by a complex set of molecules including HLA molecules present on the cell surface that inform the immune system of infection. Therefore, this project expects to generate new knowledge in the areas of cellular biology and immunology by utilising a cutting-edge and multi-disciplinary approach. Expected outcomes of this project include the generation of new knowledge of this unconventional molecule and its interaction with immune cells. This should provide significant impacts by defining the non-conventional role of HLA-E within the immune system, which may advise future research into vaccines or therapeutics. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100193
Funder
Australian Research Council
Funding Amount
$590,000.00
Summary
Next Generation Mass Spectrometry for Analysis of Biomolecules. Next-generation mass spectrometry for analysis of biomolecules:
This project seeks to establish a next-generation mass spectrometer that represents the most sensitive, accurate and rapid mass spectrometer allowing the simultaneous quantitation of several hundred to several thousand proteins in a single experiment. This is designed to particularly support infection and immunity research. Novel fragmentation capabilities and enhanced ....Next Generation Mass Spectrometry for Analysis of Biomolecules. Next-generation mass spectrometry for analysis of biomolecules:
This project seeks to establish a next-generation mass spectrometer that represents the most sensitive, accurate and rapid mass spectrometer allowing the simultaneous quantitation of several hundred to several thousand proteins in a single experiment. This is designed to particularly support infection and immunity research. Novel fragmentation capabilities and enhanced workflows on this instrument may allow new types of experiments to be conducted providing significant improvements in coverage and depth of analysis.Read moreRead less
Molecular and immunological approaches to managing Australia's seafood allergy epidemic. Seafood is an increasingly important cause of food allergy. Novel insight into the functions of why and how proteins from seafood develop to potent allergens will lead to the development of better diagnostics and therapeutics. This will assist patients to better manage their serious food allergy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100078
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Establishment of a comprehensive regional biophysical analysis facility. Interactions between molecules are needed for cells to function correctly. This facility will permit comprehensive molecular characterisation as well as research into the fundamentals of how molecules interact.
Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an i ....Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an initial screen, distinct variants and combinations of these genes were identified. This project aims to interrogate how variation in these critical genes impacts on the function of cytotoxic lymphocytes, providing insights into the evolutionary drivers of immune recognition mechanisms.Read moreRead less