Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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Decoding germination defects that threaten global wheat production. Wheat is a major commodity in Australia. Sprouting damage represents a major global threat to wheat production and food security. This project will explore the genetic and molecular mechanisms underpinning pre-harvest sprouting (PHS) and late-maturity amylase (LMA). This project will apply transcriptomics and proteomics to measure the expression of the biomolecules associated with PHS and LMA, generating fundamental knowledge of ....Decoding germination defects that threaten global wheat production. Wheat is a major commodity in Australia. Sprouting damage represents a major global threat to wheat production and food security. This project will explore the genetic and molecular mechanisms underpinning pre-harvest sprouting (PHS) and late-maturity amylase (LMA). This project will apply transcriptomics and proteomics to measure the expression of the biomolecules associated with PHS and LMA, generating fundamental knowledge of grain molecular physiology that addresses a significant knowledge gap. The project will deliver tools capable of differentiating these conditions, thereby minimising economic losses. A better understanding of the genetic basis of PHS and LMA will lay the foundation for advanced breeding aiming to eliminate these. Read moreRead less
Molecular characterisation of the Prf bacterial recognition complex of tomato. This project will investigate the composition and function of a large protein complex in tomatoes that controls their ability to resist attack by bacteria. The results will provide understanding to how all plants resist all diseases, and may help to improve environmentally-benign disease resistance in crop species.