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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100140
Funder
Australian Research Council
Funding Amount
$945,000.00
Summary
An integrated, multi-nodal bio-layer interferometry facility. Biomolecular interaction research in Australia is currently constrained by low-throughput, labor intensive techniques that impede research progress and often forces it overseas. This project aims to develop a world-class, integrated, multi-node bio-layer interferometry facility. This project expects to generate new knowledge in diverse areas of research ranging from biodiscovery to agricultural vaccine technology. Using biolayer inte ....An integrated, multi-nodal bio-layer interferometry facility. Biomolecular interaction research in Australia is currently constrained by low-throughput, labor intensive techniques that impede research progress and often forces it overseas. This project aims to develop a world-class, integrated, multi-node bio-layer interferometry facility. This project expects to generate new knowledge in diverse areas of research ranging from biodiscovery to agricultural vaccine technology. Using biolayer interferometry, the leading-edge biomolecular interaction technique will provide significant benefits by developing high-throughput assay techniques, thus enabling diverse streams of national benefit research and propelling Australia to the forefront of biomolecular interaction research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100089
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Super-resolution fluorescence microscopy. The prestigious journal Nature Methods named super-resolution fluorescent microscopy as the Method of the Year 2008. This recognition is justified because fluorescent imaging on the molecular scale will revolutionise biological sciences. It will literally change the way we see the smallest building blocks of life and this allows researchers to identify the function of proteins and lipids in health and disease. This breakthrough technology is currently no ....Super-resolution fluorescence microscopy. The prestigious journal Nature Methods named super-resolution fluorescent microscopy as the Method of the Year 2008. This recognition is justified because fluorescent imaging on the molecular scale will revolutionise biological sciences. It will literally change the way we see the smallest building blocks of life and this allows researchers to identify the function of proteins and lipids in health and disease. This breakthrough technology is currently not available to researchers in Australia. Super-resolution fluorescence microscopy would extend Australia's leading position in the fundamental biological sciences, bio- and nano-technologies as well as imaging and microscopy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100204
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
A systems biology capability for the Ramaciotti Centre for Genomics. A systems biology capability for the Ramaciotti Centre for Genomics:
The project aims to introduce a complete systems biology capability to the Ramaciotti Centre for Genomics. This is intended to provide a complete systems biology workflow, including improved data analysis for next-generation sequencing, tissue preparation and imaging, and mass spectrometry for proteomics and metabolomics. This would enable a truly systems app ....A systems biology capability for the Ramaciotti Centre for Genomics. A systems biology capability for the Ramaciotti Centre for Genomics:
The project aims to introduce a complete systems biology capability to the Ramaciotti Centre for Genomics. This is intended to provide a complete systems biology workflow, including improved data analysis for next-generation sequencing, tissue preparation and imaging, and mass spectrometry for proteomics and metabolomics. This would enable a truly systems approach to biological problems, supporting researchers and projects that focus on microbial and mammalian metabolism, carbohydrate chemistry and synthetic biology. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100036
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
A protein molecular interaction and localization facility. This proposal will address a major gap in our mass spectrometry capabilities and aid in our understanding of protein interactions and tissue distribution in areas such as neuroscience, microbiology, immunology, and botany, as well as enhance our understanding of fundamental gas phase chemistry of protein molecules. It brings together a highly successful multidisciplinary team of high-profile researchers with a track record of collaborati ....A protein molecular interaction and localization facility. This proposal will address a major gap in our mass spectrometry capabilities and aid in our understanding of protein interactions and tissue distribution in areas such as neuroscience, microbiology, immunology, and botany, as well as enhance our understanding of fundamental gas phase chemistry of protein molecules. It brings together a highly successful multidisciplinary team of high-profile researchers with a track record of collaboration and delivering outcomes from shared facilities. In addition to these key scientific outcomes this project will also facilitate the training of several new personnel in a skill area for which there is a critical shortage (mass spectrometry) and promote true cross-disciplinary skills.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100092
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
A high-throughput protein production and structure facility. Making proteins and studying their structures and properties is a key activity in biotechnology, drug design, food security and bio-nanotechnology. The Protein Production and Structure Facility will provide Western Australian researchers and their international partners with world-class resources to pursue this research for the benefit of all Australians.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100150
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Beyond Proteomics: structure and function of protein modifications. The world's leading cancer therapeutics have come from the protein phosphorylation field, and glycomics has led to drugs that combat the flu and that stimulate red blood cell production in cancer patients. Thus there is a bright future for discovery of new medicines based on new knowledge in this area. Protein modifications are key to the understanding of disease mechanisms and for searching for new disease markers and new the ....Beyond Proteomics: structure and function of protein modifications. The world's leading cancer therapeutics have come from the protein phosphorylation field, and glycomics has led to drugs that combat the flu and that stimulate red blood cell production in cancer patients. Thus there is a bright future for discovery of new medicines based on new knowledge in this area. Protein modifications are key to the understanding of disease mechanisms and for searching for new disease markers and new therapeutics. In the hands of local experts the instruments will enable identification of these modifications and provide improved understanding of biology, increase the national competitiveness of Australia's scientists, and provide advanced technology training to the next generation of scientists.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100101
Funder
Australian Research Council
Funding Amount
$160,000.00
Summary
Better, faster, cheaper: improving shotgun proteomics by using high-speed ion trap mass spectrometry. This mass spectrometric instrumentation is a breakthrough in technology and an essential step in maintaining the world-class capabilities of the Australian research community. Many fundamental and applied biochemical research studies will benefit from access to this system, generating a positive societal impact.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100096
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Biomolecular Interaction Facility. Biomolecular interaction facility: A biomolecular interaction facility located in Perth is essential to support the research performed by a growing community of key protein researchers. The infrastructure provided by this integrated facility will act as a hub for analysis of samples produced by high-throughput protein production methods and will provide high-level training with cutting-edge equipment for researchers at all levels. It will underpin faster and be ....Biomolecular Interaction Facility. Biomolecular interaction facility: A biomolecular interaction facility located in Perth is essential to support the research performed by a growing community of key protein researchers. The infrastructure provided by this integrated facility will act as a hub for analysis of samples produced by high-throughput protein production methods and will provide high-level training with cutting-edge equipment for researchers at all levels. It will underpin faster and better fundamental and translational research in the areas of structural biology, biotechnology, biomedical science, plant science and nanotechnology, supporting the activities of researchers and their collaborators in Australia and worldwide.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100096
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
Advanced high resolution mass spectrometer for collaborative proteomic and lipidomics research. The equipment will make possible targeted research for the comprehensive high sensitivity analysis of proteins and lipids. Permitting a unique understanding of how these molecules interact within normal or diseased cells and other samples.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100134
Funder
Australian Research Council
Funding Amount
$796,206.00
Summary
Super-resolution platform to accelerate biological and molecular research. This application aims to establish a new molecular analysis platform integrating a microfluid capillary electrophoresis interface directly to a mass spectrometer with advanced data scanning technology. This enables label-free detection, quantitation and characterisation of intact proteins, lipids and metabolites with unprecedented sensitivity, resolution and throughput. It will enhance ARC projects spanning natural produc ....Super-resolution platform to accelerate biological and molecular research. This application aims to establish a new molecular analysis platform integrating a microfluid capillary electrophoresis interface directly to a mass spectrometer with advanced data scanning technology. This enables label-free detection, quantitation and characterisation of intact proteins, lipids and metabolites with unprecedented sensitivity, resolution and throughput. It will enhance ARC projects spanning natural product discovery, biotechnology, agriculture, and animal, plant and marine biology, as well as single-cell proteomics, lipidomics and metabolomics. It will ensure Australia remains at the forefront of molecular and biological research and create new training and collaborative opportunities both nationally and internationally.Read moreRead less