Engaging Augmented Reality on 3D Head Up Displays to Reduce Risky Driving. This project aims to reduce risky driving behaviours through novel augmented reality applications for three-dimensional head-up displays, making safe driving more engaging so that drivers will take less risk. Over 1 million people are killed and 50 million are seriously injured on roads each year worldwide. Risky driving behaviours (speeding and distracted driving) are major causes. This project intends to produce novel i ....Engaging Augmented Reality on 3D Head Up Displays to Reduce Risky Driving. This project aims to reduce risky driving behaviours through novel augmented reality applications for three-dimensional head-up displays, making safe driving more engaging so that drivers will take less risk. Over 1 million people are killed and 50 million are seriously injured on roads each year worldwide. Risky driving behaviours (speeding and distracted driving) are major causes. This project intends to produce novel in-car interaction design implementations, provide important visual design guidelines for future display technologies, and provide novel road safety interventions.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease. Through the combination of expertise from the Industry partner and the Hume group this project aims to develop specific inhibitors of the CSF-1 receptor protein tyrosine kinase in order to demonstrate their efficacy as modulators of CSF-1 dependent macrophage and tumour cell function in vitro. The expected outcome will be a lead set of targets which can be further assessed for therapeutic pote ....The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease. Through the combination of expertise from the Industry partner and the Hume group this project aims to develop specific inhibitors of the CSF-1 receptor protein tyrosine kinase in order to demonstrate their efficacy as modulators of CSF-1 dependent macrophage and tumour cell function in vitro. The expected outcome will be a lead set of targets which can be further assessed for therapeutic potential in clinical trials.Read moreRead less
Covalent Hydrogen Bond Mimetics of Helical Peptide Hormones. Peptide hormones have been identified that adopt a helical shape when bound to their receptor. The project will produce new versions of these hormones by the use of directly bonded chemical linkers in place of the relatively weak helix hydrogen bonds. The resulting hormone mimics will be more stable, have lower molecular weight and be more selective than the natural hormones making them more suitable as drugs. Our new chemical techn ....Covalent Hydrogen Bond Mimetics of Helical Peptide Hormones. Peptide hormones have been identified that adopt a helical shape when bound to their receptor. The project will produce new versions of these hormones by the use of directly bonded chemical linkers in place of the relatively weak helix hydrogen bonds. The resulting hormone mimics will be more stable, have lower molecular weight and be more selective than the natural hormones making them more suitable as drugs. Our new chemical techniques allow us for the first time to fully investigate this approach which if successful will be applicable to many other helical peptides and therefore could be an important drug development technique.Read moreRead less
Participatory Visualisation & Assessment of Risks: A Crowdsourcing Approach. The aim of this study is to develop and evaluate innovative interaction and visualisation approaches that allow the insurance sector to include social media and crowdsourced data in risk identification and assessment. This data, combined with traditional risk assessment information, offers time-critical insights into emerging hazards and threats. The study aims to deliver methods and tools to crowdsource data from contr ....Participatory Visualisation & Assessment of Risks: A Crowdsourcing Approach. The aim of this study is to develop and evaluate innovative interaction and visualisation approaches that allow the insurance sector to include social media and crowdsourced data in risk identification and assessment. This data, combined with traditional risk assessment information, offers time-critical insights into emerging hazards and threats. The study aims to deliver methods and tools to crowdsource data from contributors through sensing and active sharing, as well as novel interaction and visualisation approaches to aid in the analysis of the resulting data. The project intends to benefit both the insurers and the insured by making non-traditional data sources available for risk assessment and prevention.Read moreRead less
Developing and evaluating a theoretically grounded novice driver education program incorporating simulators. Australian young drivers are 13 per cent of the population but account for nearly a quarter of road deaths. This project aims to develop a research informed, theory-driven education intervention that includes a simulator component to improve their driving skills and attitudes. A process and outcome evaluation aims to assess the effectiveness of the training including the impact on how ind ....Developing and evaluating a theoretically grounded novice driver education program incorporating simulators. Australian young drivers are 13 per cent of the population but account for nearly a quarter of road deaths. This project aims to develop a research informed, theory-driven education intervention that includes a simulator component to improve their driving skills and attitudes. A process and outcome evaluation aims to assess the effectiveness of the training including the impact on how individuals learn to drive, changes in skill and attitudes as well as the influence on crashes and offences. It is intended that a second parallel study will adapt the intervention for Indigenous Australians and examine the effectiveness of this adaptation.Read moreRead less
Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by ....Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches.
Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption.
Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers. Read moreRead less
Eat, cook, grow: Ubiquitous technology for sustainable food culture in the city. Raising people's awareness of healthy and ecological food options with nutritional data and educational information does not foster a sustained practice towards a more environmentally friendly food culture. This study seeks to develop a better understanding how to go beyond just informing and into supporting and sustaining action and change. Drawing on interaction design, ubiquitous computing and real- time informat ....Eat, cook, grow: Ubiquitous technology for sustainable food culture in the city. Raising people's awareness of healthy and ecological food options with nutritional data and educational information does not foster a sustained practice towards a more environmentally friendly food culture. This study seeks to develop a better understanding how to go beyond just informing and into supporting and sustaining action and change. Drawing on interaction design, ubiquitous computing and real- time information, the study will deliver research findings that inform viable new design approaches and information interfaces which will strengthen Australia's position to resolve the problems of obesity, malnutrition and ecological issues of mass food processing, and contribute to the sustainability of life in Australian cities.Read moreRead less
New information access technologies for people with intellectual disability. New information access technologies for people with intellectual disability. This project aims to co-design a social, interactive and visual internet search interface for people with intellectual disability. Enabling choice and independence is key to the new National Disability Insurance Scheme, but people with intellectual disability are effectively excluded from much of the Web. This project will investigate ways to a ....New information access technologies for people with intellectual disability. New information access technologies for people with intellectual disability. This project aims to co-design a social, interactive and visual internet search interface for people with intellectual disability. Enabling choice and independence is key to the new National Disability Insurance Scheme, but people with intellectual disability are effectively excluded from much of the Web. This project will investigate ways to access and provide information using technologies such as interactive avatars, virtual worlds and trusted social support. New interfaces will enable people with intellectual disability to inform themselves, make choices and foster their social inclusion. Expected outcomes are new search interface technology, a theoretical framework and new Web accessibility guidelines.Read moreRead less
Designing work roles for crew operating multiple unmanned aircraft. The aim of this project is to identify how work roles should be designed for crew operating multiple Unmanned Aircraft (UA). Industry expects that the introduction of higher levels of automation in next-generation UA systems will reduce the operational costs associated with UA by enabling human crews to simultaneously manage multiple aircraft. The current project examines the safety and effectiveness of different types of work d ....Designing work roles for crew operating multiple unmanned aircraft. The aim of this project is to identify how work roles should be designed for crew operating multiple Unmanned Aircraft (UA). Industry expects that the introduction of higher levels of automation in next-generation UA systems will reduce the operational costs associated with UA by enabling human crews to simultaneously manage multiple aircraft. The current project examines the safety and effectiveness of different types of work designs for these systems. The primary outcome will be a set of recommendations regarding the design of work roles for the crew of next-generation UA systems. Expected benefits include improvements in safety and cost-effectiveness of next-generation UA systems.Read moreRead less