Socio-economic determinants and health inequalities over the life course: Australian and English comparisons. Our multidisciplinary investigation will yield Australia's first major body of knowledge on the socio-economic determinants of health and health inequalities over the life course. It will point the way towards policies that can promote health and reduce the health inequalities experienced by disadvantaged individuals and families. It will indicate how improving the health of ageing Aus ....Socio-economic determinants and health inequalities over the life course: Australian and English comparisons. Our multidisciplinary investigation will yield Australia's first major body of knowledge on the socio-economic determinants of health and health inequalities over the life course. It will point the way towards policies that can promote health and reduce the health inequalities experienced by disadvantaged individuals and families. It will indicate how improving the health of ageing Australian men and women can increase productivity and reduce needs for health services during the rapid population ageing that lies ahead. Comparisons with England will inform policy choices. We will train researchers who will play a future role in building Australia's evidence base to guide constructive policies to 2020 and beyond.Read moreRead less
Statistical Inference for Probability-Linked Longitudinal Data. The Strategic Roadmap for the Australian Government's National Collaborative Research Infrastructure Strategy states that analysis of linked data, and particularly linked longitudinal data, has the potential to revolutionise Australian public health research. Similar benefits should flow from analysis of linked datasets in other areas, e.g. the Statistical Longitudinal Census Dataset that the Australian Bureau of Statistics intends ....Statistical Inference for Probability-Linked Longitudinal Data. The Strategic Roadmap for the Australian Government's National Collaborative Research Infrastructure Strategy states that analysis of linked data, and particularly linked longitudinal data, has the potential to revolutionise Australian public health research. Similar benefits should flow from analysis of linked datasets in other areas, e.g. the Statistical Longitudinal Census Dataset that the Australian Bureau of Statistics intends to create by linking individual records across censuses. These benefits will be maximised by controlling the impact of linkage error when analysing these datasets. This proposal will develop the statistical theory and related methodology to solve this problem in a statistically efficient manner.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
The dynamics of spousal relationships in very late life: transitions, psychological health and longevity. This research will provide a rare insight into the dynamics of very-long term successful marriages. It will also provide an understanding of the dyad in ageing well. In a society where a large percentage of marriages end in divorce, this work has the potential to identify individual differences factors that are conducive to sustaining the marital relationship. In addition, an examination o ....The dynamics of spousal relationships in very late life: transitions, psychological health and longevity. This research will provide a rare insight into the dynamics of very-long term successful marriages. It will also provide an understanding of the dyad in ageing well. In a society where a large percentage of marriages end in divorce, this work has the potential to identify individual differences factors that are conducive to sustaining the marital relationship. In addition, an examination of how couples from different socio-economic backgrounds navigate later life in their own homes or during key late life transitions will also be beneficial for those individuals or policy makers planning for these transitions.Read moreRead less
Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community. Australia's ageing population will have substantial economic and social ramifications. This study will contribute knowledge to the development and application of environmental and housing policies designed to promote health and public health and clinical interventions intended to combat the major contributors to disease and disability in older populations. Knowled ....Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community. Australia's ageing population will have substantial economic and social ramifications. This study will contribute knowledge to the development and application of environmental and housing policies designed to promote health and public health and clinical interventions intended to combat the major contributors to disease and disability in older populations. Knowledge of factors that improve health and promote mobility, independence, social interaction and life satisfaction will also assist planning future age-congregated living environments. The research falls within national priority goals including ageing well, ageing productively, preventative healthcare, and strengthening Australia's social and economic fabric.Read moreRead less
Adaptive capabilities in the elderly during extreme heat events in South Australia. This study, using first hand accounts of experiences and perceptions of the extreme heat event of 2009 in South Australia, will provide a valuable insight into the heat adaptive capability of the ageing population, factors affecting susceptibility, and ways to curb the predicted increase in often life-threatening heat exacerbated illnesses, many of which require extended hospital stays. It is envisaged that findi ....Adaptive capabilities in the elderly during extreme heat events in South Australia. This study, using first hand accounts of experiences and perceptions of the extreme heat event of 2009 in South Australia, will provide a valuable insight into the heat adaptive capability of the ageing population, factors affecting susceptibility, and ways to curb the predicted increase in often life-threatening heat exacerbated illnesses, many of which require extended hospital stays. It is envisaged that findings will help inform health policy and contribute to the formulation of a National Heatwave Response plan. Study findings will be disseminated widely at government (state and federal), non-government, and community levels and will help to raise the awareness of heat exacerbated illness in general.Read moreRead less
A prospective study of the transition to grandparenthood: psychosocial adjustment, well-being and productive ageing. Given the increasingly common childcare role that grandparents are required to play in Australian society, and the increasing demands of grandparenting, potential benefits arising from this study adhere to the requirements of the National Research Priority Area "Promoting and Maintaining Good Health." They include: identifying the characteristics of the group of grandparents for w ....A prospective study of the transition to grandparenthood: psychosocial adjustment, well-being and productive ageing. Given the increasingly common childcare role that grandparents are required to play in Australian society, and the increasing demands of grandparenting, potential benefits arising from this study adhere to the requirements of the National Research Priority Area "Promoting and Maintaining Good Health." They include: identifying the characteristics of the group of grandparents for whom the change of role and lifestyle produces negative effects; providing increased awareness in health professionals and the lay community about this subgroup, enabling appropriate early identification and intervention; supplying evidence-based data to inform strategies to reduce stress in the grandparents and improve the quality of childcare they provide.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
From rehabilitation to recovery after stroke : a model to optimise consumer and carer involvement. The National Research Priorities include 'ageing well, ageing productively'. Within this priority, it is necessary to be inclusive of those who have ongoing disabilities and/or chronic disease. This project aims to facilitate healthy lifestyles and community involvement in a group who have significant barriers to achieving their potential. The high incidence of depression and poor quality of life i ....From rehabilitation to recovery after stroke : a model to optimise consumer and carer involvement. The National Research Priorities include 'ageing well, ageing productively'. Within this priority, it is necessary to be inclusive of those who have ongoing disabilities and/or chronic disease. This project aims to facilitate healthy lifestyles and community involvement in a group who have significant barriers to achieving their potential. The high incidence of depression and poor quality of life in stroke survivors and their carers emphasises the need to enhance wellness in these people. The study will develop a model for promoting recovery and community reintegration in stroke survivors, with the goal of enabling stroke survivors and their carers to actively participate in the community and pursue personal goals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882890
Funder
Australian Research Council
Funding Amount
$130,000.00
Summary
Investigating protein/protein interactions. To establish and maintain a prominent position in scientific research, Australian scientists must have access to state of the art technology. The Bio21 Institute is a multidisciplinary research centre specialising in medical agricultural and environmental science and is ideally suited to house an SPR facility. SPR provides unique functional, kinetic and thermodynamic information on molecular interactions which give rise to both physiological and path ....Investigating protein/protein interactions. To establish and maintain a prominent position in scientific research, Australian scientists must have access to state of the art technology. The Bio21 Institute is a multidisciplinary research centre specialising in medical agricultural and environmental science and is ideally suited to house an SPR facility. SPR provides unique functional, kinetic and thermodynamic information on molecular interactions which give rise to both physiological and pathological outcomes. A detailed knowledge of molecular interactions is fundamental to the understanding of all biological systems. When placed at the Bio21 Institute, the facility will foster the development of diversified collaborations between the applicants and the wider research community.Read moreRead less