Growing up to be supersonic: bat echolocation origins and mechanics. This project aims to address the unresolved evolutionary origins of bat echolocation. Using a unique combination of development, evolution and novel engineering testing, this project expects to generate new insights into how features of the skull have evolved to allow bats to use their senses to interact with the environment. Expected outcomes include the identification of skull features that are unique to echolocating bats and ....Growing up to be supersonic: bat echolocation origins and mechanics. This project aims to address the unresolved evolutionary origins of bat echolocation. Using a unique combination of development, evolution and novel engineering testing, this project expects to generate new insights into how features of the skull have evolved to allow bats to use their senses to interact with the environment. Expected outcomes include the identification of skull features that are unique to echolocating bats and tests of how these relate to the frequency and detection range of sounds produced. Benefits include improved conservation planning for urban and rural bat populations, and potential commercial advances through engineering applications that mimic the biological process of echolocation. Read moreRead less
Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use ....Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use survey data that follows them over time to: 1) identify family structures that enhance or harm health and wellbeing, and; 2) track changes in health and wellbeing before, during and after family transitions (i.e. births, relationship changes). Anticipated results are better targeted policy interventions to reduce Indigenous health inequalities.Read moreRead less
Violence, Religion and Well-being in Contemporary Burma (Myanmar): A Medical Anthropological Study of Everyday Life Under Dictatorship. For 40 years, Burma has been controlled by a military dictatorship with human rights abuses occurring daily. Terror and political violence are used as tools of repression. An in-depth ethnographic study will be conducted into the relationship between emotional/psychological distress and the violence and fear that pervades everyday Burmese life. The project will ....Violence, Religion and Well-being in Contemporary Burma (Myanmar): A Medical Anthropological Study of Everyday Life Under Dictatorship. For 40 years, Burma has been controlled by a military dictatorship with human rights abuses occurring daily. Terror and political violence are used as tools of repression. An in-depth ethnographic study will be conducted into the relationship between emotional/psychological distress and the violence and fear that pervades everyday Burmese life. The project will test the hypothesis that religion plays an important role in mediating responses to fear. No other study has been conducted of everday life under this dictatorship, or of survival strategies created to alleviate fear. Outcomes will include refereed articles, a major monograph on the subject and the development of a new methodology appropriate for aiding victims of terror and torture.Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.
The Market for Technology in Australia. Over the last 5 years, formalised markets for technology have accelerated in the US. However, there is no recognised formal market in Australia. Results from our primary data collection and analysis will highlight whether deficiencies in the market for technology are creating obstacles for the commercialisation of Australian technology. This is a particularly important issue for Australia given our relative isolation arising from geographical distance and ....The Market for Technology in Australia. Over the last 5 years, formalised markets for technology have accelerated in the US. However, there is no recognised formal market in Australia. Results from our primary data collection and analysis will highlight whether deficiencies in the market for technology are creating obstacles for the commercialisation of Australian technology. This is a particularly important issue for Australia given our relative isolation arising from geographical distance and lack of attachment to a major trading bloc such as the EU or NAFTA.Read moreRead less
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less