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Developing Drugs To Prevent Prostate Cancer Spread.
Funder
National Health and Medical Research Council
Funding Amount
$99,248.00
Summary
Current therapies for prostate cancer lose their efficacy as the cancer advances. Moreover, despite the spread of cancer being the major cause of prostate cancer mortality, there is no therapy available which selectively targets this process, thus new agents are needed. By using computer modelling to predict molecules that bind to the cell surface protein CD151 and testing these in biological assays, we aim to discover molecules that reduce cell migration of prostate cancer and that can be devel ....Current therapies for prostate cancer lose their efficacy as the cancer advances. Moreover, despite the spread of cancer being the major cause of prostate cancer mortality, there is no therapy available which selectively targets this process, thus new agents are needed. By using computer modelling to predict molecules that bind to the cell surface protein CD151 and testing these in biological assays, we aim to discover molecules that reduce cell migration of prostate cancer and that can be developed into anti-migration drugs.Read moreRead less
HtrA4-induced Endothelial Dysfunction In Early-onset Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$86,073.00
Summary
Preeclampsia (PE), a life-threatening disorder of pregnancy, is characterized by a sudden increase in blood pressure in association with wide-spread endothelial dysfunction. Placenta-derived factors are believed to cause PE development. Our recent studies have identified that HtrA4, a placenta-specific serine protease may contribute to endothelial dysfunction. This study will investigate the mechanisms of HtrA4-induced endothelial dysfunction.
Enhancer RNAs As Cancer Drivers And Predictive Biomarkers Of BET Inhibitor Therapy
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
BET inhibitors are a new type of therapy designed to slow down cancer growth by switching off cancer genes. In individuals with colon and prostate cancer, BET inhibitors have shown good initial results, but these are not long-lasting. By measuring blood levels of a specific type of RNA (a close companion of DNA), called CCAT1 and PCAT1, we hope to better understand which patients gain the most benefit from BET inhibitors, and the mechanisms that cause BET inhibitors to stop working.
Identifying Neuroanatomical Sub-phenotypes Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$60,129.00
Summary
The clinical presentation of schizophrenia is varied across individuals, and has arguably hindered efforts to determine its cause/s. This project seeks to address this issue by investigating biological commonality in patients, to identify subgroups of schizophrenia patients with similar brain abnormalities, with the overall aim to examine cognitive and clinical characteristics and candidate genetic markers in association with biologically derived subtypes of schizophrenia.
The search for genetic vulnerability in autism research has been hindered by the assumption that the different symptoms which define the disorder can be attributed to the same causal mechanism. Instead it has been suggested that the social and non-social aspects of autism spectrum conditions (ASC) have distinct causes at genetic, cognitive and neural levels. This study will assess the autism phenotype across individuals with a high, medium or low genetic vulnerability to autism.
Evaluation Of New Biomarkers Of Coagulation In High Risk Cardiovascular Population
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Predicting the cardiovascular risk of an individual remains challenging despite the current advances and to date, there is no available laboratory testing that accurately reflects an individual’s clotting profile. This prospective study aims to address this with the use of global coagulation assay as a novel tool for individual cardiovascular risk prognostication and management, as well as demonstrate the compensatory mechanism between the different arms of Virchow's triad.
Blood Pressure Effects On Placental Growth And Development
Funder
National Health and Medical Research Council
Funding Amount
$133,357.00
Summary
Diseases causing high blood pressure in pregnancy or preeclampsia are a major cause of complications in mother and infant. At present, the only treatment is delivery of the baby who may be premature or too small. Why preeclampsia develops is incompletely understood and the long term consequences of this disease for the mother includes doubling of the future risk of heart and kidney disease. This research will look at the placenta or afterbirth at a molecular level to better understand why this d ....Diseases causing high blood pressure in pregnancy or preeclampsia are a major cause of complications in mother and infant. At present, the only treatment is delivery of the baby who may be premature or too small. Why preeclampsia develops is incompletely understood and the long term consequences of this disease for the mother includes doubling of the future risk of heart and kidney disease. This research will look at the placenta or afterbirth at a molecular level to better understand why this disease occurs.Read moreRead less
In Vitro And In Vivo Investigation Of Actin Regulation In The Malaria Parasite
Funder
National Health and Medical Research Council
Funding Amount
$92,294.00
Summary
Malaria parasites move in a unique way. They move across cell surfaces and infect human cells using a unique molecular motor that allows them to, literally, glide. The research proposal outlined here is focused on understanding a key part of the motor – the dynamic protein actin – and by understanding how it is regulated develop new potential targets for novel drugs that might stop movement and, therefore, help prevent or treat malaria disease.
Functional Aspects Of CD52 Signalling In Immune Regulation
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Autoimmune disease, such as Rheumatoid arthritis, Type 1-Diabetes, Lupus and Multiple Sclerosis, is caused by disruptions in the normal control of the immune system. A type of cell called a regulatory T-cell can prevent these damaging immune reactions. However, we do not know how T-cells do this. CD52 is a protein found on the surface of T-cells. Our preliminary work shows that CD52 also suppresses these damaging immune responses. This project researches how CD52 influences the immune system.
The Role Of Paramyxovirus P Protein Subcellular Trafficking In Virus Pathogenicity And Antagonism Of Host Interferon Responses
Funder
National Health and Medical Research Council
Funding Amount
$78,491.00
Summary
Emerging zoonotic viruses pose a major health threat worldwide, highlighted by recent outbreaks of viruses such as Nipah and Hendra via interspecies invasion to infect humans. A major barrier to interspecies infection is the innate immune response, which viruses must evolve to combat before successful infection can occur. We aim to examine in detail the mechanisms underlying immune evasion of such viruses, with the ultimate goal of discovering novel targets for therapeutics to viral infection.