Design of new two-dimensional materials for lithium sulphur batteries. Design of new two-dimensional materials for lithium sulphur batteries. This project aims to develop classes of electrode material systems for high performance batteries. This project will design new hierarchical cathode composites for a high capacity lithium-sulphur battery with a long cycling life. It intends to improve energy density by confining active sulphur in conductive graphene and exfoliated titanium dioxide nanoshee ....Design of new two-dimensional materials for lithium sulphur batteries. Design of new two-dimensional materials for lithium sulphur batteries. This project aims to develop classes of electrode material systems for high performance batteries. This project will design new hierarchical cathode composites for a high capacity lithium-sulphur battery with a long cycling life. It intends to improve energy density by confining active sulphur in conductive graphene and exfoliated titanium dioxide nanosheets, and use a unique hybrid protecting layer to suppress cycling instability. This research is expected to establish the relationship between synthetic conditions, structure, and electrochemical performance.Read moreRead less
Scalable nanomechanical information processing. This project aims to build the first scalable computer architecture based on nanoscale motion on a silicon chip. Such nanomechanical computers could extend computing performance in space and earth-orbit applications, and in other environments where intense radiation causes digital electronics to fail. The project intends to utilise recent advances in nanomechanics and nanofabrication to demonstrate all key nanomechanical circuit elements, including ....Scalable nanomechanical information processing. This project aims to build the first scalable computer architecture based on nanoscale motion on a silicon chip. Such nanomechanical computers could extend computing performance in space and earth-orbit applications, and in other environments where intense radiation causes digital electronics to fail. The project intends to utilise recent advances in nanomechanics and nanofabrication to demonstrate all key nanomechanical circuit elements, including transistors, logic gates, memories and analogue-to-digital converters and to deliver a roadmap for commercialisation of the technology in Australia. The expected outcome of this project is the development of the underpinning nanotechnologies, predicted to have wide uses in sensing, health and communications,and which could improve heat management and energy efficiency in future computers. This new approach to computing has potential for near-term commercial impact in the aerospace industry, building on Australian know-how.Read moreRead less
Scalable and reversible computing with integrated nanomechanics. This project aims to build the first scalable computing architecture based on nanomechanical motion, integrated on a silicon chip and proven in harsh environments. This could extend the performance of computers in space and high-radiation environments, e.g. allowing robust satellite stabilisation. The project will leverage our know-how in phononics and nanofabrication to enable previously unprecedented control of nanomechanical mot ....Scalable and reversible computing with integrated nanomechanics. This project aims to build the first scalable computing architecture based on nanomechanical motion, integrated on a silicon chip and proven in harsh environments. This could extend the performance of computers in space and high-radiation environments, e.g. allowing robust satellite stabilisation. The project will leverage our know-how in phononics and nanofabrication to enable previously unprecedented control of nanomechanical motion, and exquisitely low energy dissipation. It aims to construct a nanomechanical processor capable of digital servo control, built from nanomechanical waveguides, transistors, logic gates and analogue-to-digital converters. It will also develop reversible logic gates, a key step towards ultralow-power computing.Read moreRead less
Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. ....Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. The development of technological innovations based on fabricated nanomaterials, will also enhance capacity in frontier technology such as nanotechnology, and build Australia’s strength in using new biosensing technologies.Read moreRead less
Indoor Photovoltaics Enabled by Wide-Bandgap Perovskite Quantum Dots. This project aims to develop a high-efficiency indoor photovoltaic (PV) technology to provide reliable low-cost power in the multi-billion dollar “Internet of Things” (IoT) market. There are currently no devices that meet the requirements for maximum operating efficiency under indoor illumination. We propose to solve this problem by fabricating PV cells using colloidal perovskite quantum dots that offer class-leading stability ....Indoor Photovoltaics Enabled by Wide-Bandgap Perovskite Quantum Dots. This project aims to develop a high-efficiency indoor photovoltaic (PV) technology to provide reliable low-cost power in the multi-billion dollar “Internet of Things” (IoT) market. There are currently no devices that meet the requirements for maximum operating efficiency under indoor illumination. We propose to solve this problem by fabricating PV cells using colloidal perovskite quantum dots that offer class-leading stability and band gap tunability across the required range, enabled by quantum confinement. The outcome is the development of integrated self-powered IoT devices potentially impacting Advanced Manufacturing growth in Energy, Cyber Security, Food and Agribusiness, as all of these will ultimately rely on networked smart devices.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease. Through the combination of expertise from the Industry partner and the Hume group this project aims to develop specific inhibitors of the CSF-1 receptor protein tyrosine kinase in order to demonstrate their efficacy as modulators of CSF-1 dependent macrophage and tumour cell function in vitro. The expected outcome will be a lead set of targets which can be further assessed for therapeutic pote ....The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease. Through the combination of expertise from the Industry partner and the Hume group this project aims to develop specific inhibitors of the CSF-1 receptor protein tyrosine kinase in order to demonstrate their efficacy as modulators of CSF-1 dependent macrophage and tumour cell function in vitro. The expected outcome will be a lead set of targets which can be further assessed for therapeutic potential in clinical trials.Read moreRead less
Covalent Hydrogen Bond Mimetics of Helical Peptide Hormones. Peptide hormones have been identified that adopt a helical shape when bound to their receptor. The project will produce new versions of these hormones by the use of directly bonded chemical linkers in place of the relatively weak helix hydrogen bonds. The resulting hormone mimics will be more stable, have lower molecular weight and be more selective than the natural hormones making them more suitable as drugs. Our new chemical techn ....Covalent Hydrogen Bond Mimetics of Helical Peptide Hormones. Peptide hormones have been identified that adopt a helical shape when bound to their receptor. The project will produce new versions of these hormones by the use of directly bonded chemical linkers in place of the relatively weak helix hydrogen bonds. The resulting hormone mimics will be more stable, have lower molecular weight and be more selective than the natural hormones making them more suitable as drugs. Our new chemical techniques allow us for the first time to fully investigate this approach which if successful will be applicable to many other helical peptides and therefore could be an important drug development technique.Read moreRead less
Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by ....Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches.
Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption.
Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers. Read moreRead less