Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100096
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Biomolecular Interaction Facility. Biomolecular interaction facility: A biomolecular interaction facility located in Perth is essential to support the research performed by a growing community of key protein researchers. The infrastructure provided by this integrated facility will act as a hub for analysis of samples produced by high-throughput protein production methods and will provide high-level training with cutting-edge equipment for researchers at all levels. It will underpin faster and be ....Biomolecular Interaction Facility. Biomolecular interaction facility: A biomolecular interaction facility located in Perth is essential to support the research performed by a growing community of key protein researchers. The infrastructure provided by this integrated facility will act as a hub for analysis of samples produced by high-throughput protein production methods and will provide high-level training with cutting-edge equipment for researchers at all levels. It will underpin faster and better fundamental and translational research in the areas of structural biology, biotechnology, biomedical science, plant science and nanotechnology, supporting the activities of researchers and their collaborators in Australia and worldwide.Read moreRead less
Probing JNK MAPK function with peptide inhibitors. It has generally been accepted that the JNK MAPK family of protein kinases is rapidly and potently activated following the exposure of mammalian cells to stresses and cytokines. However, their biological role has remained controversial. We believe that this problem reflects the lack of a generally applicable and specific JNK MAPK inhibitor. In this project we continue our characterisation of a small peptide inhibitor developed in our laboratori ....Probing JNK MAPK function with peptide inhibitors. It has generally been accepted that the JNK MAPK family of protein kinases is rapidly and potently activated following the exposure of mammalian cells to stresses and cytokines. However, their biological role has remained controversial. We believe that this problem reflects the lack of a generally applicable and specific JNK MAPK inhibitor. In this project we continue our characterisation of a small peptide inhibitor developed in our laboratories. We aim to determine its mechanism of inhibition, the specificity of interaction, and to evolve more effective inhibitors. With these new inhibitors, we can effectively address the biological roles of these kinases.Read moreRead less