Discovery Early Career Researcher Award - Grant ID: DE120100282
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The formation and regulation of ovarian follicular fluid. At ovulation in mammals the egg and its surrounding fluid are released from the ovary, yet we understand very little about how fluid accumulates in the ovary in the first place. This project will for the first time discover how this fluid forms, and what controls its rate of formation.
Deciphering the cellular functions of caveolae that govern lymphatic vascular development. Lymphatic vessels play crucial roles in tissue fluid homeostasis, immunity, and fatty acid transport. Despite our recent understanding of genetic pathways that modulate lymphatic cell fate specification, how cellular changes mediate morphogenesis of the lymphatic tree remains to be elucidated. This study will combine cell biology and developmental genetics approaches using mouse and zebrafish transgenic li ....Deciphering the cellular functions of caveolae that govern lymphatic vascular development. Lymphatic vessels play crucial roles in tissue fluid homeostasis, immunity, and fatty acid transport. Despite our recent understanding of genetic pathways that modulate lymphatic cell fate specification, how cellular changes mediate morphogenesis of the lymphatic tree remains to be elucidated. This study will combine cell biology and developmental genetics approaches using mouse and zebrafish transgenic lines that label lymphatic endothelial cells to investigate the role of caveolae proteins in the construction of the lymphatic vascular network. This project aims to improve our fundamental understanding of the processes that govern vascular system assembly and will broaden basic knowledge of organ morphogenesis. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100172
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Comprehensive cell imaging facility. This facility will provide Australian biological science researchers with equipment for in-depth analyses of cell function in vitro and in vivo. It will enable innovative research targeted at important questions in fields including cancer, immunology, stem cell biology, infectious disease and tissue regeneration.
Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by ....Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches.
Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption.
Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers. Read moreRead less