Polarity in lymphocytes: Regulation of immune function and cancer. The Fellow will elucidate the mechanisms and consequences of a fundamental new phenomenon in immunology. This is likely to profoundly impact upon approaches to detecting and treating immune-related diseases such as autoimmunity, transplantation, vaccination and immunodeficiencies. The ongoing project and the work that led to our discovery involves interdisciplinary collaborations between physicists and biologists to apply frontie ....Polarity in lymphocytes: Regulation of immune function and cancer. The Fellow will elucidate the mechanisms and consequences of a fundamental new phenomenon in immunology. This is likely to profoundly impact upon approaches to detecting and treating immune-related diseases such as autoimmunity, transplantation, vaccination and immunodeficiencies. The ongoing project and the work that led to our discovery involves interdisciplinary collaborations between physicists and biologists to apply frontier laser technologies to biological studies. These technologies will not only facilitate our elucidation of immune development and function, but will also be made available to other research in Australia and overseas.Read moreRead less
Intelligent Freeform Bio-fabrication for Customised Anatomical Structures for Reconstructive Surgery. This project contributes towards the ARC priority goal on advanced materials and frontier technologies by developing an intelligent freeform biofabrication facility to produce accurate anatomical biocompatible replica structures and implants for reconstructive surgery. The products, produced from patient's CT or MRI scan data, will contribute to complex surgical procedure planning and patient ed ....Intelligent Freeform Bio-fabrication for Customised Anatomical Structures for Reconstructive Surgery. This project contributes towards the ARC priority goal on advanced materials and frontier technologies by developing an intelligent freeform biofabrication facility to produce accurate anatomical biocompatible replica structures and implants for reconstructive surgery. The products, produced from patient's CT or MRI scan data, will contribute to complex surgical procedure planning and patient education. The proposed facility will be based on multifunctional freeform fabrication process supported by intelligent software tools and database of biocompatible materials. The prospective outcomes are likely to have an excellent commercial and patenting potential that may help Australia become a leader in biomanufacturing technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560716
Funder
Australian Research Council
Funding Amount
$864,610.00
Summary
A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The o ....A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The outcome will be a strategically important Australian T-ray facility that will provide immediate and transparent nationwide access. Historically, industry is transformed every time a new part of the electromagnetic spectrum becomes accessible - T-rays are the next frontier.Read moreRead less
Exploring the Dynamics of Nanostructure Self-Organisation during Compound Semiconductor Epitaxy. The application of LEEM to GaAs and InAs will be a world first, positioning Australia at the forefront of nanoscale self-organisation, leading to important international recognition and publicity. The spectacular movies obtained will revolutionise our basic understanding of compound semiconductor self-organisation and facilitate an improved control over nanostructure fabrication using MBE. This will ....Exploring the Dynamics of Nanostructure Self-Organisation during Compound Semiconductor Epitaxy. The application of LEEM to GaAs and InAs will be a world first, positioning Australia at the forefront of nanoscale self-organisation, leading to important international recognition and publicity. The spectacular movies obtained will revolutionise our basic understanding of compound semiconductor self-organisation and facilitate an improved control over nanostructure fabrication using MBE. This will generate entirely new device structures relevant to the frontier technologies of photonics and quantum information processing. The project will provide high level training for post-graduate and honours students in nanoscale characterisation and synchrotron science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347356
Funder
Australian Research Council
Funding Amount
$238,000.00
Summary
Real-time multi-dimensional multi-photon microscopy facility. The proposal seeks to establish an integrated microscopy facility and thus to expand the high-resolution imaging capabilities at Swinburne University of Technology, Peter MacCallum Cancer Institute and the University of Melbourne. The provision of the equipment requested will establish an innovative real-time multi-dimensional multi-photon imaging facility of world class. This facility will be accessed on a cooperative basis by the pa ....Real-time multi-dimensional multi-photon microscopy facility. The proposal seeks to establish an integrated microscopy facility and thus to expand the high-resolution imaging capabilities at Swinburne University of Technology, Peter MacCallum Cancer Institute and the University of Melbourne. The provision of the equipment requested will establish an innovative real-time multi-dimensional multi-photon imaging facility of world class. This facility will be accessed on a cooperative basis by the participants and will be available for collaborative projects with other Australian institutions and industry. The requested equipment will be used in conjunction with existing femtosecond laser and lifetime imaging systems installed in the research laboratories of the participating institutions. The facility will enable real-time investigations of biomolecular processes and the development of novel biomedical imaging techniques as well as the state-of-the-art nanophotonic devices such as nano-tweezers and nano compact disks.Read moreRead less
Haptic exploration and manipulation of micro/nano scale environment. The proposed research is novel and innovative in character and it has potential benefits in many frontier areas utilising micro/nano manipulation systems. These include micromanufacturing and instrumentation, microbiology, microsurgery and nanotechnology. The outcomes of this project will add to the growth of world-class Australian engineering science, and consolidate Australia's position in innovative technologies and internat ....Haptic exploration and manipulation of micro/nano scale environment. The proposed research is novel and innovative in character and it has potential benefits in many frontier areas utilising micro/nano manipulation systems. These include micromanufacturing and instrumentation, microbiology, microsurgery and nanotechnology. The outcomes of this project will add to the growth of world-class Australian engineering science, and consolidate Australia's position in innovative technologies and international R&D. This highly challenging project will provide training for postdoctorate researchers, postgraduate and honours students. These researchers will gain expertise in many areas including micro/nano manipulation, sensing and control, system design and analysis, virtual reality and experimental techniques.Read moreRead less
Elucidating the mechanisms by which Scribble, Discs Large and Lethal Giant Larvae regulate epithelial polarity. Discs Large (Dlg) and Scribble are proteins that regulate cell shape by concentrating at particular regions within the cell and recruiting other proteins to that region. It is thought that the two proteins interact with each other, and with other proteins involved in protein trafficking and cell architecture, but it is not known how these events coordinate to produce a net outcome on ....Elucidating the mechanisms by which Scribble, Discs Large and Lethal Giant Larvae regulate epithelial polarity. Discs Large (Dlg) and Scribble are proteins that regulate cell shape by concentrating at particular regions within the cell and recruiting other proteins to that region. It is thought that the two proteins interact with each other, and with other proteins involved in protein trafficking and cell architecture, but it is not known how these events coordinate to produce a net outcome on cell shape. To answer these questions, the dynamic events involved in localization of Dlg, Scribble, and associated proteins will be determined, in mammalian cells and in whole organs of the vinegar fly.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883073
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
BigNet - A Distributed Wireless Sensor Network Testbed. The infrastructure developed will be of national /international significance, given the rapid emergence of wireless sensor networks. This integrated facility will allow Australia to be a world leading player in the research and technology development as well as the socially responsible deployment of sensor networks. The facility has the explicit aim to ensure that Australia is a technology leader rather than solely a technology user in sens ....BigNet - A Distributed Wireless Sensor Network Testbed. The infrastructure developed will be of national /international significance, given the rapid emergence of wireless sensor networks. This integrated facility will allow Australia to be a world leading player in the research and technology development as well as the socially responsible deployment of sensor networks. The facility has the explicit aim to ensure that Australia is a technology leader rather than solely a technology user in sensor networks. The test facility will mirror practical requirements for WSN implementation in the Great Barrier Reef and in timber plantation, which would offer substantial economic benefits to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239467
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A portable laser scanning facility for geomatic data capture. Ground-based laser scaning is an emerging technology that promises to revolutionize spatial data capture for the geomatics industry due to its high data volume, accuracy and acquisition rate. This proposal brings together leading academics from Australasia to establish a laser scanning facility that will enhance existing projects and explore new avenues in geomatic research. The facility will impact on the research programs of partici ....A portable laser scanning facility for geomatic data capture. Ground-based laser scaning is an emerging technology that promises to revolutionize spatial data capture for the geomatics industry due to its high data volume, accuracy and acquisition rate. This proposal brings together leading academics from Australasia to establish a laser scanning facility that will enhance existing projects and explore new avenues in geomatic research. The facility will impact on the research programs of participating institutions in the fields of high-resolution thematic mapping and visualization, environmental geomatics, geomatic monitoring and geomatic engineering. Furthermore, the facility will allow Australasian universities to develop a knowledge base in this new and exciting technology.Read moreRead less
Improved fibre Bragg grating sensors for detection of structural hot spots. Structural integrity monitoring, to anticipate and prevent failure, is a multi-billion dollar effort worldwide. Detailed assessment of the capability of fibre Bragg gratings to measure strain profiles along the grating length, i.e. intragrating sensing, and thereby detect structural ?hot spots? before failure is essential for effective systems. They will be used to determine strain gradients similar to those found in com ....Improved fibre Bragg grating sensors for detection of structural hot spots. Structural integrity monitoring, to anticipate and prevent failure, is a multi-billion dollar effort worldwide. Detailed assessment of the capability of fibre Bragg gratings to measure strain profiles along the grating length, i.e. intragrating sensing, and thereby detect structural ?hot spots? before failure is essential for effective systems. They will be used to determine strain gradients similar to those found in common problem areas, such as the tips of elliptic notches and disbonding at the ends of composite joints. Additionally, grating refractive index profiles will be characterised using imaging techniques, to assess performance and possible changes to gratings after prolonged use.Read moreRead less