EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation ....Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation of results. While theoretical developments of this project are general, in the sense that they are not restricted to particular engineering disciplines, the four chosen applications closely align with two major research priorities namely An Environmental Sustainable Australia and Promoting and Maintaining Good Health.Read moreRead less
Design guideline for suction caissons supporting offshore wind turbines. This project aims to develop an industry guideline for suction caisson foundations, that are a new form of fixed platform anchor, for offshore wind turbines. The project expects to generate new knowledge of caisson response during installation and over millions of wind/wave load cycles, by integrating field experience with measurements from innovative experiments. The expected outcomes of this project include new methods to ....Design guideline for suction caissons supporting offshore wind turbines. This project aims to develop an industry guideline for suction caisson foundations, that are a new form of fixed platform anchor, for offshore wind turbines. The project expects to generate new knowledge of caisson response during installation and over millions of wind/wave load cycles, by integrating field experience with measurements from innovative experiments. The expected outcomes of this project include new methods to guide suction installation in difficult soil layering and predicting rotation and stiffness over a turbine’s operational life. The benefits of these scientific advances will contribute to the economic and reliable design of suction caisson foundations and a more rapid take-up of offshore wind energy.Read moreRead less
Crusty Seabeds: From (Bio-)Genesis To Reliable Offshore Design. The project aims to make deep water oil and gas developments safer and cheaper by understanding better the unique seabed ‘crust’ conditions that occur in Australian waters. By studying the biogenic, structural and mechanical properties of deepwater crusts in more detail than can be done in ‘live’ oil and gas projects, this project expects to make a step change in the understanding of these seabed crusts. Expected outcomes of this pr ....Crusty Seabeds: From (Bio-)Genesis To Reliable Offshore Design. The project aims to make deep water oil and gas developments safer and cheaper by understanding better the unique seabed ‘crust’ conditions that occur in Australian waters. By studying the biogenic, structural and mechanical properties of deepwater crusts in more detail than can be done in ‘live’ oil and gas projects, this project expects to make a step change in the understanding of these seabed crusts. Expected outcomes of this project include developing new seabed investigation and design approaches for these soils. This should provide significant benefits, by facilitating the design and installation of low-risk, yet low cost seabed infrastructure (e.g. pipelines, risers, shallow foundations etc.) in these problematical seabed typesRead moreRead less
Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material fail ....Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material failure associated with the high impact forces. Expected outcomes of the project include a conceptual framework and scientific-based design tool to predict the geotechnical performance of offshore installations. The research will provide the necessary scientific advances to install, moor and service offshore wind and wave energy devices more economically and efficiently.Read moreRead less
A novel foundation to extend the operation of mobile structures into deeper water. Oil and gas is a key industry in Australia, contributing A$17 billion to the economy. However, with the large accessible reserves in shallower waters becoming exhausted, Australian oil and gas companies require new technologies to extend their capabilities. The research in this proposal addresses this concern, providing an extension of the operational depth range of mobile jack-up platforms from 120 to 200 m. This ....A novel foundation to extend the operation of mobile structures into deeper water. Oil and gas is a key industry in Australia, contributing A$17 billion to the economy. However, with the large accessible reserves in shallower waters becoming exhausted, Australian oil and gas companies require new technologies to extend their capabilities. The research in this proposal addresses this concern, providing an extension of the operational depth range of mobile jack-up platforms from 120 to 200 m. This creates the opportunity to develop the significant number of Australia's smaller gas fields that are currently uneconomical to exploit. The proposed project will contribute to the future competitiveness of Australia's oil and gas industry and ensuring energy supply for the sustained growth of the Australian economy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less