EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.
Targeted Development Of AMPK Β2-isoform Allosteric Activators
Funder
National Health and Medical Research Council
Funding Amount
$898,147.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to dramatic increases in the incidence of diseases associated with metabolic dysregulation e.g. type 2 diabetes. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as a cellular fuel gauge. We have discovered a new drug that crucially activates the form of AMPK found in metabolically active organs. We aim to develop this drug to unlock new therapeutic opportunity.
Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be ca ....Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be catastrophic. By establishing an improved understanding of internal erosion as a sequence of processes on various scales, from the onset of erosion until the failure of the structure, this project will place Australia at the forefront of dam safety assessment.Read moreRead less
A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.
Failure Mechanisms of Roof Cladding under Fluctuating Wind Loads. Wind damage to low-rise buildings cause disruption to communities and result in economic losses. Improvements to the most vulnerable part (i.e. roof) will therefore have national benefits and associated economic benefits. Currently, roofing systems used in cyclonic areas are evaluated to DABM in the Northern Territory and to TR440 elsewhere, requiring the same product be tested under two different (and unsatisfactory) specificat ....Failure Mechanisms of Roof Cladding under Fluctuating Wind Loads. Wind damage to low-rise buildings cause disruption to communities and result in economic losses. Improvements to the most vulnerable part (i.e. roof) will therefore have national benefits and associated economic benefits. Currently, roofing systems used in cyclonic areas are evaluated to DABM in the Northern Territory and to TR440 elsewhere, requiring the same product be tested under two different (and unsatisfactory) specifications. This is due to the limited understanding of wind-induced fatigue of cladding. This project will provide the framework for understanding and minimizing cladding fatigue. A realistic single test will also reduce cost and result in better design systems.Read moreRead less
The response of beams subjected to axial load and lateral soil movements. Beams (piles, soil nails, and pipelines) are not only subjected to axial (vertical, axial and longitudinal)loading, but often withstand simultaneous lateral loading, due to either explicit structural loads, or due to loads induced by movement of the soils in which they are founded. Bridge piles adjacent to an approach embankment are one example. This project will provide experimental evidence to assist with the estimation ....The response of beams subjected to axial load and lateral soil movements. Beams (piles, soil nails, and pipelines) are not only subjected to axial (vertical, axial and longitudinal)loading, but often withstand simultaneous lateral loading, due to either explicit structural loads, or due to loads induced by movement of the soils in which they are founded. Bridge piles adjacent to an approach embankment are one example. This project will provide experimental evidence to assist with the estimation of capacity, axial and shear resistance, the validation of unified solutions for beams subjected to simultaneous lateral soil movements and axial loads. Such experimental evidence and analytical solutions are not currently available. The evidence will also assist with solving a contradictory, existing design principle, which will lead to an economic and efficient design approach.Read moreRead less
Harnessing properties of liquid metals for future devices. This project aims to hybridise low toxicity liquid metal alloys of gallium with surface confined functional micro/nano materials and explore fundamental new fluidic and physical-chemistry phenomena. Liquid metals are an under-used group of materials, but their combination of flexibility, bestowed by their room temperature fluidity, and metallic properties means they demonstrate startling behaviour. The expected outcomes are new devices a ....Harnessing properties of liquid metals for future devices. This project aims to hybridise low toxicity liquid metal alloys of gallium with surface confined functional micro/nano materials and explore fundamental new fluidic and physical-chemistry phenomena. Liquid metals are an under-used group of materials, but their combination of flexibility, bestowed by their room temperature fluidity, and metallic properties means they demonstrate startling behaviour. The expected outcomes are new devices and systems such as reconfigurable and highly efficient actuators/generators, catalysts, sensors, and electronic and optical components.Read moreRead less
This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.