Biosensor Based Clinical-decision Support For Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$691,933.00
Summary
Heart Failure (HF) is a progressive disease and a major global public health concern. HF accounts for a substantial number of hospitalisations, major healthcare resource utilisation and costs. We aim to engineer biosensor platform to stratify the risk in HF patients will revolutionise current management of HF by providing the cardiologist information to risk stratify patients based on protein signature. This will lead to a substantial paradigm shift in clinical practice.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be ca ....Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be catastrophic. By establishing an improved understanding of internal erosion as a sequence of processes on various scales, from the onset of erosion until the failure of the structure, this project will place Australia at the forefront of dam safety assessment.Read moreRead less
Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hard ....Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hardware, software and communication systems to dynamically generate decision tools for safe and efficient power system operating conditions. These systems will also generate alarms if any risky operational situations arise.Read moreRead less
Development of Fibre Reinforced Autoclaved Aerated Concrete Products. The construction industry is one of the world's largest consumers of raw materials and it is widely accepted that current material usage trends are unsustainable. Development of new more efficient construction materials is paramount to overcoming this. This novel research will use advanced high strength glass and carbon fibres and polymer resins to improve the structural behaviour, versatility and economic viability of a natio ....Development of Fibre Reinforced Autoclaved Aerated Concrete Products. The construction industry is one of the world's largest consumers of raw materials and it is widely accepted that current material usage trends are unsustainable. Development of new more efficient construction materials is paramount to overcoming this. This novel research will use advanced high strength glass and carbon fibres and polymer resins to improve the structural behaviour, versatility and economic viability of a nationally significant construction material known as Autoclaved Aerated Concrete. The material technologies developed by this research will lead to more efficient material use, a more sustainable materials solution and the potential to export the technology worldwide.Read moreRead less
Poro-elastic, single domain model of wave-induced transport and transformation of pollutants in coastal sediments. The sediments in many bays and estuaries in Australia are contaminated by pollutants due to discharge of waste from the river, groundwater or/and ocean outfall. Most previous research has had a multi-domain approach and have ignored the wave-dirven advective flow and effects of soil behaviour in coastal sediment. In this study, we will couple the procedure of pollutant transport ne ....Poro-elastic, single domain model of wave-induced transport and transformation of pollutants in coastal sediments. The sediments in many bays and estuaries in Australia are contaminated by pollutants due to discharge of waste from the river, groundwater or/and ocean outfall. Most previous research has had a multi-domain approach and have ignored the wave-dirven advective flow and effects of soil behaviour in coastal sediment. In this study, we will couple the procedure of pollutant transport near the sediment-water interface by a single domain approach, and link wave-dirven advective flow and contaminant in marine sediments. The research outcomes will provide a better prediction of the transformation behaviour of pollutants in contaminated sediments.Read moreRead less
Rigorous Three Dimensional Plasticity Solutions for Soil and Rock Slopes. Slope failures and landslides are a persistent cause of economic loss in Australia. Damages resulting from landslides include both property damage and loss of life. One such recent catastrophic slope failure is the landslide that occurred at Thredbo Village in New South Wales in 1997. This monumental landslide resulted in the deaths of 18 people and was considered by the coroner as the worst natural disaster in Australian ....Rigorous Three Dimensional Plasticity Solutions for Soil and Rock Slopes. Slope failures and landslides are a persistent cause of economic loss in Australia. Damages resulting from landslides include both property damage and loss of life. One such recent catastrophic slope failure is the landslide that occurred at Thredbo Village in New South Wales in 1997. This monumental landslide resulted in the deaths of 18 people and was considered by the coroner as the worst natural disaster in Australian history. The primary aim of this research project is to apply recently developed computational tools to better understand 3D slope behaviour and to develop rigorous stability solutions that can be used by design engineers. A better understanding of 3D slope failure will lead to more economic and safer slope designs.Read moreRead less
Modelling of sand wave migration and its interaction with pipelines. The movement of sand due to sand waves can interfere with marine structures such as pipelines and cables on the seabed. It may also cause free spans of pipelines, with potentially serious consequences. Most previous research has considered sand wave propagation and the stability of pipelines as separate problems. In this project, we propose a coupled analysis of sand wave migration and its interaction with pipelines through mat ....Modelling of sand wave migration and its interaction with pipelines. The movement of sand due to sand waves can interfere with marine structures such as pipelines and cables on the seabed. It may also cause free spans of pipelines, with potentially serious consequences. Most previous research has considered sand wave propagation and the stability of pipelines as separate problems. In this project, we propose a coupled analysis of sand wave migration and its interaction with pipelines through mathematical and numerical modelling. The theoretical work will be supported by laboratory experiments. The resulting research will provide a better understanding of sand wave migration, beach profiles and the stability of pipelines.Read moreRead less
Coupling models for ocean waves, groundwater and porous seabeds interaction. The ocean waves, groundwater flow and porous seabeds interaction problem is vital for erosion control, saltily and biological activities in coastal regions. Most previous research has investigated the problem from individual aspects, rather than a coupling concept. In this study, we will develop advanced theoretical models for procedures of waves propagation, water table fluctuations and soil behaviour in a porous seabe ....Coupling models for ocean waves, groundwater and porous seabeds interaction. The ocean waves, groundwater flow and porous seabeds interaction problem is vital for erosion control, saltily and biological activities in coastal regions. Most previous research has investigated the problem from individual aspects, rather than a coupling concept. In this study, we will develop advanced theoretical models for procedures of waves propagation, water table fluctuations and soil behaviour in a porous seabed, and couple them in a model. A series of experiments will be conducted for the verification of the theoretical findings. The research outcomes will provide a better understanding of the interaction between ocean wave, groundwater flow and porous seabeds.Read moreRead less