Platelet Glycoprotein Proteolysis: Novel Mechanisms And Risk Factors
Funder
National Health and Medical Research Council
Funding Amount
$441,473.00
Summary
Platelets are the richest source of amyloid precursor protein (APP) in the body. Platelet ADAM10 regulates both the expression and function of the major platelet collagen receptor GPVI, and protective APP processing. Coagulation protein Factor X has a role in activation of ADAM10. This activation is disrupted in blood that has been treated with direct oral anticoagulant (DOAC) rivaroxaban. This grant will investigate the implications for people taking rivaroxaban on regulation of APP and GPVI.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100015
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation ....ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation of infrastructure design in Australia and internationally. Achieving carbon neutral infrastructure in its whole life will bring significant far-reaching benefits, including equipping industry with tools required to meet Australia’s emission reduction targets as well as economic, commercial, environmental, and social gains.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100006
Funder
Australian Research Council
Funding Amount
$3,937,625.00
Summary
ARC Training Centre for Advanced Technologies in Rail Track Infrastructure. The ARC Training Centre for Advanced Technologies in Rail Track Infrastructure aims to transform Australia’s rail construction and maintenance technologies through specialist training of industry-focused researchers. Generation of new knowledge and close collaboration with companies within the rail supply chain will result in enhanced rail capacity and supply chain efficiency across the rail network. This will include in ....ARC Training Centre for Advanced Technologies in Rail Track Infrastructure. The ARC Training Centre for Advanced Technologies in Rail Track Infrastructure aims to transform Australia’s rail construction and maintenance technologies through specialist training of industry-focused researchers. Generation of new knowledge and close collaboration with companies within the rail supply chain will result in enhanced rail capacity and supply chain efficiency across the rail network. This will include increased axle loads and higher speeds, greater safety margins, reduced construction and maintenance costs, and a body of competent railway professionals in the nation’s work force.Read moreRead less
Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization ....Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization tools and numerical models. The final outcome of the project will be a set of designs of the columns, which should be more efficient, safer and cheaper to operate, and have smaller physical and environmental footprints, thus helping the Australian LNG industry to stay globally competitive.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC180100030
Funder
Australian Research Council
Funding Amount
$3,925,357.00
Summary
ARC Training Centre for Transforming Maintenance through Data Science. The ARC Training Centre for Transforming Maintenance through Data Science aims to equip practising engineers and Australian graduates with the next generation of data science methods for the maintenance sector. The Centre plans to introduce timely and cost-efficient maintenance scheduling by developing data-intensive mathematical and computational algorithms for asset management and fault prediction. The Centre’s overarching ....ARC Training Centre for Transforming Maintenance through Data Science. The ARC Training Centre for Transforming Maintenance through Data Science aims to equip practising engineers and Australian graduates with the next generation of data science methods for the maintenance sector. The Centre plans to introduce timely and cost-efficient maintenance scheduling by developing data-intensive mathematical and computational algorithms for asset management and fault prediction. The Centre’s overarching objectives are to enable development and adoption of new practices to improve productivity and asset reliability for industry and to foster a new maintenance technology service sector for national and international markets.Read moreRead less
Microbiologically Induced Stress Corrosion Cracking in Underground Mines. Premature brittle failure of rock & cable bolts due to stress corrosion cracking can cause fatalities and serious damage, and has been reported in several mining operations across Australia and world-wide. The evidence suggests that microbial activity is a contributing factor. The project aims to implement experimental methodologies to determine the specific conditions responsible for bolt failure and develop novel prevent ....Microbiologically Induced Stress Corrosion Cracking in Underground Mines. Premature brittle failure of rock & cable bolts due to stress corrosion cracking can cause fatalities and serious damage, and has been reported in several mining operations across Australia and world-wide. The evidence suggests that microbial activity is a contributing factor. The project aims to implement experimental methodologies to determine the specific conditions responsible for bolt failure and develop novel prevention techniques applicable in underground mines. The benefits of this research will be improved understanding of the environment causing catastrophic failure of bolts and avoidance of potential hazards & economic loss in mining projects. This will lead to improved safety & increased productivity in mining operations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560716
Funder
Australian Research Council
Funding Amount
$864,610.00
Summary
A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The o ....A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The outcome will be a strategically important Australian T-ray facility that will provide immediate and transparent nationwide access. Historically, industry is transformed every time a new part of the electromagnetic spectrum becomes accessible - T-rays are the next frontier.Read moreRead less
Special Research Initiatives - Grant ID: SR0354778
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Deep Earth Resource Characterisation and Extraction - An Integrated Geoscience Approach. Sustainability, economy and safety in resource recovery require a high level of understanding of the mechanics of geomaterials in their natural conditions and a multidisciplinary approach to the geotechnical issues involved. This initiative aims to bridge gaps between geotechnical disciplines, to combine the testing, analytical skills and experience of the research groups and to incorporate expertise and ide ....Deep Earth Resource Characterisation and Extraction - An Integrated Geoscience Approach. Sustainability, economy and safety in resource recovery require a high level of understanding of the mechanics of geomaterials in their natural conditions and a multidisciplinary approach to the geotechnical issues involved. This initiative aims to bridge gaps between geotechnical disciplines, to combine the testing, analytical skills and experience of the research groups and to incorporate expertise and ideas from the cognate disciplines of geology and geophysics so that innovative engineering practice will develop. This approach should achieve breakthroughs in understanding the behaviour of, and the safe economic extraction from deep resources including minerals, coal, gas drainage, petroleum and geothermal energy.Read moreRead less