Plant Mitochondrial Signalling and Regulation. Plant energy production is essential for successful growth and development and is essential for processes such as seedling establishment and germination. This research project intends to expand our understanding of energy regulation within the plant using advanced technologies. Such studies can provide direct benefits to the Australian agriculture community through novel targets for genetic improvements. The capacity to create such advantages is eco ....Plant Mitochondrial Signalling and Regulation. Plant energy production is essential for successful growth and development and is essential for processes such as seedling establishment and germination. This research project intends to expand our understanding of energy regulation within the plant using advanced technologies. Such studies can provide direct benefits to the Australian agriculture community through novel targets for genetic improvements. The capacity to create such advantages is economically vital for the industry and the development of such expertise within Australia will ensure we are well placed to exploit future advances in agricultural improvements and provide the capacity to further generate novel biotechnological applications.Read moreRead less
A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle. Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how the ....A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle. Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how these cell signaling proteins are organized into pathways and how this microorganism controls its complex growth and developmental cycle, we will be able to develop novel methods of control. We are at the fore front of international research and therefore uniquely placed to conduct this project.Read moreRead less
The effect of tunelling on existing rock bolts. As more underground facilities such as rail, road, sewerage and service tunnels are constructed in our major cities, more and more frequently new tunnels have to cross over or run alongside existing tunnels. As the roofs of tunnels are generally supported by rock bolts and lined with shotcrete, the support system can be damaged by the rock movements caused by the excavation of the new tunnel. Little research has been carried out on this problem, an ....The effect of tunelling on existing rock bolts. As more underground facilities such as rail, road, sewerage and service tunnels are constructed in our major cities, more and more frequently new tunnels have to cross over or run alongside existing tunnels. As the roofs of tunnels are generally supported by rock bolts and lined with shotcrete, the support system can be damaged by the rock movements caused by the excavation of the new tunnel. Little research has been carried out on this problem, and so often expensive deviations have to be made to tunnels to avoid going near existing ones. The proposed research will provide numerical tools to allow prediction of loads induced into rock bolts by nearby tunnels, leading to more economical and safer tunnel design.
Read moreRead less
A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to ....A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.Read moreRead less
Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches ....Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches and wave barriers to dissipate wave propagation, and in structural engineering to estimate in-structure vibration level and design isolators for sensitive equipment housed within. The technique will involve fundamental advances in the scaled boundary finite-element method, as calculations will be performed in a moving reference frame.Read moreRead less
Time-dependent dynamic, creep and shrinkage response of curved structural members. This project concerns curved structural members, such as bridge beams, that are subjected to dynamic excitation and to concrete shrinkage and creep. Hitherto, unified formulations for the structural behaviour of these members have not been properly developed. The proposal seeks to build on a previous ARC DP of the investigator that produces significant results for static loading, by developing a sophisticated meth ....Time-dependent dynamic, creep and shrinkage response of curved structural members. This project concerns curved structural members, such as bridge beams, that are subjected to dynamic excitation and to concrete shrinkage and creep. Hitherto, unified formulations for the structural behaviour of these members have not been properly developed. The proposal seeks to build on a previous ARC DP of the investigator that produces significant results for static loading, by developing a sophisticated methodology to handle non-static dynamic loading and for shrinkage and creep. It will develop advanced mathematical tools to enable the safe and efficient design of a multiplicity of structures that is of benefit to on and offshore Australian technology.Read moreRead less
Mathematical and mechanical modeling of nano particulate flow. Nano particulates are the basis for many new technologies, including coatings in the electronics industry, composite materials and medical and pharmaceutical applications. Worldwide industrial competition is increasingly determined by our capacity to handle such highly cohesive materials, and to exploit their novel physical, chemical and mechanical characteristics. Devising handling mechanisms and understanding nano particulate flows ....Mathematical and mechanical modeling of nano particulate flow. Nano particulates are the basis for many new technologies, including coatings in the electronics industry, composite materials and medical and pharmaceutical applications. Worldwide industrial competition is increasingly determined by our capacity to handle such highly cohesive materials, and to exploit their novel physical, chemical and mechanical characteristics. Devising handling mechanisms and understanding nano particulate flows depends on formulating accurate mathematical models which reflect the correct underlying physics. This APF proposal will utilise advanced continuum mechanics to develop the correct underlying conceptual ideas to resolve fundamental nanomechanical particulate flows, which will lead to the next generation of engineering tools.
Read moreRead less
Structural studies on the mitochondrial protein import machinery. Proteins transported across biological membranes are generally synthesized as precursors with signal sequences. These signal sequences are decoded by one of a number of membrane-specific protein transport machinery, but how this decoding occurs is largely unknown. This proposal aims to understand the structural basis of protein import into the mitochondrion, a poorly understood biological process. This study will enhance signif ....Structural studies on the mitochondrial protein import machinery. Proteins transported across biological membranes are generally synthesized as precursors with signal sequences. These signal sequences are decoded by one of a number of membrane-specific protein transport machinery, but how this decoding occurs is largely unknown. This proposal aims to understand the structural basis of protein import into the mitochondrion, a poorly understood biological process. This study will enhance significantly our understanding of mitochondrial biology, and will also have ramifications for other areas of protein transport.Read moreRead less
Guanylate cyclases - an expanding family critical in plant growth and development. The enzyme guanylate cyclase (GC) forms an important signalling molecule. We have identified unique GC molecules from higher plants. We shall use strategic basic research to determine the biological importance of these novel molecules in plant growth and development. We have formed an international team to achieve these goals and also to develop strong scientific links between Australia and other countries such as ....Guanylate cyclases - an expanding family critical in plant growth and development. The enzyme guanylate cyclase (GC) forms an important signalling molecule. We have identified unique GC molecules from higher plants. We shall use strategic basic research to determine the biological importance of these novel molecules in plant growth and development. We have formed an international team to achieve these goals and also to develop strong scientific links between Australia and other countries such as South Africa. The outcomes will provide new insight into the biological function of the novel GCs. Consequently, the new knowledge is critical to the development of novel biotechnological approaches to benefit sustainable agriculture in Australia.Read moreRead less
Regulation of the actin cytoskeleton by LIM kinase 2. Because the regulation of actin cytoskeleton is essential for many cellular processes including cell motility and the normal function of neurons, it is of great importance to understand its regulation. Elucidation of the molecular and biological mechanisms underlying the actin cytoskeleton including cell motility may enable the identification of novel therapeutic targets for the treatment of diseases such as cancer metastasis, Alzheimer disea ....Regulation of the actin cytoskeleton by LIM kinase 2. Because the regulation of actin cytoskeleton is essential for many cellular processes including cell motility and the normal function of neurons, it is of great importance to understand its regulation. Elucidation of the molecular and biological mechanisms underlying the actin cytoskeleton including cell motility may enable the identification of novel therapeutic targets for the treatment of diseases such as cancer metastasis, Alzheimer disease (AD) and/or Multiple Sclerosis (MS) in which the regulation of the actin cytoskeleton is affected.
Read moreRead less