Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347955
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first ....A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first cell-sorting facility dedicated to the production of nerve cells suitable for molecular characterization and screening, providing the basis for identifying key molecules regulating brain function, ageing and repair of great importance to the biotechnology/pharmaceutical industry.Read moreRead less
The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking. The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the- ....The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking. The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the-art structural and molecular cell biology research. By addressing an area of great interest internationally the project will have the capacity to increase Australia's knowledge base and strengthen it's reputation for research excellence.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Endosomal Protein Transport: From Molecular Structures to Biological Function. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights ....Endosomal Protein Transport: From Molecular Structures to Biological Function. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights into endosomal trafficking at the molecular level. Outcomes from this work will place Australia at the forefront of international efforts to understand this essential biological process and will have important implications for future design of pharmaceuticals.Read moreRead less
Towards Distributed Phased Array Radar for High Resolution Weather Monitoring. Several recent reports on climate change by leading international and national bodies forecast that the rate of weather hazards such as storms and wind-shear, and of weather-associated phenomena such as bush fires will increase over the next 40 years. The current technology for monitoring weather events, and effects like wind-shift, which has a serious impact on dangers associated with bush fires, has significant wea ....Towards Distributed Phased Array Radar for High Resolution Weather Monitoring. Several recent reports on climate change by leading international and national bodies forecast that the rate of weather hazards such as storms and wind-shear, and of weather-associated phenomena such as bush fires will increase over the next 40 years. The current technology for monitoring weather events, and effects like wind-shift, which has a serious impact on dangers associated with bush fires, has significant weaknesses. We will deliver considerable improvements in monitoring capability by developing the technology for using a network of small phased array radars. We aim to place monitoring resources where end-user needs are greatest.Read moreRead less
Next Generation Planar Tellurite Waveguides. The project provides the basis for the production of new high technology photonic products in Australia, the availability of at least one new unique facility for future scientific endeavour, and the generation of skillsets new to Australia. New IP will also be developed during the project. A successful outcome could also ultimately result in new products offering, for example, enhanced National Security through the Defence applications, better measure ....Next Generation Planar Tellurite Waveguides. The project provides the basis for the production of new high technology photonic products in Australia, the availability of at least one new unique facility for future scientific endeavour, and the generation of skillsets new to Australia. New IP will also be developed during the project. A successful outcome could also ultimately result in new products offering, for example, enhanced National Security through the Defence applications, better measurements of atmospheric contaminants through the sensing route, and more advanced telecommunications services at lower cost for citizens and businesses, and for lower operating costs for service providers.
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Digital Outsourcing in Architecture: Opportunities for Australian Firms or Perils for Australian Workforce? This research will help assess competitiveness and viability of different digital outsourcing practices in connection to the needs, the operative conditions and the products of the Australian building design sector. The information will give industry analysts a tool to identify the markets within which these arrangements are likely to spread or occur in the future, and take consequent corr ....Digital Outsourcing in Architecture: Opportunities for Australian Firms or Perils for Australian Workforce? This research will help assess competitiveness and viability of different digital outsourcing practices in connection to the needs, the operative conditions and the products of the Australian building design sector. The information will give industry analysts a tool to identify the markets within which these arrangements are likely to spread or occur in the future, and take consequent corrective or supportive action. The outcomes of this project will benefit Australia by forecasting changes in professional employment prospects, and by providing a framework to consider development scenarios for architectural educational and professional institutions, national research and development priorities, and international trade agreement agendas.Read moreRead less
Conserving native wildlife during urbanisation: the effectiveness of biodiversity-friendly urban design and construction practices. Urbanisation has many negative effects upon native wildlife and their habitats, but biodiversity-friendly urban design and construction practices may greatly reduce these impacts. This study will examine the effectiveness of such measures at sustaining wildlife at sites of urban development, and will therefore produce significant benefits for local residents and the ....Conserving native wildlife during urbanisation: the effectiveness of biodiversity-friendly urban design and construction practices. Urbanisation has many negative effects upon native wildlife and their habitats, but biodiversity-friendly urban design and construction practices may greatly reduce these impacts. This study will examine the effectiveness of such measures at sustaining wildlife at sites of urban development, and will therefore produce significant benefits for local residents and the broader Australian community. Healthy natural ecosystems in urban areas provide many services to the public, reduce the need for costly management, and improve the livelihood of residents living in greener environments. This study will enhance all these community benefits through a detailed examination of the effectiveness of biodiversity-friendly urban development measures.Read moreRead less
Management of Complex Assets Using Smart Information Systems. The aim is to develop an integrative framework and a smart system for holistic asset management in order to manage and optimise asset decisions vis-a-vis shifts in customer and market needs. It will develop an advanced conceptual framework, a dedicated smart system that is capable of handling uncertainty often associated with decision making in large complex operations. The benefits of this research are: a more competitive indusry wit ....Management of Complex Assets Using Smart Information Systems. The aim is to develop an integrative framework and a smart system for holistic asset management in order to manage and optimise asset decisions vis-a-vis shifts in customer and market needs. It will develop an advanced conceptual framework, a dedicated smart system that is capable of handling uncertainty often associated with decision making in large complex operations. The benefits of this research are: a more competitive indusry with focus on markets; a smart system to demonstrate business-based decision making and generally a much more sophisticated approach to asset management.Read moreRead less
The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly enga ....The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly engage questions of value in a novel and revealing way, and how its connection with 'hard' sciences was not merely to provide a methodological gloss on these, but went to the core of what scientific explanation consisted in.Read moreRead less