Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100031
Funder
Australian Research Council
Funding Amount
$630,000.00
Summary
PacBio long read sequencer for the Ramaciotti Genomics Consortium of NSW. PacBio long read sequencer for the Ramaciotti Genomics Consortium of New South Wales: This will be one of the first PacBio sequencers for a service facility in Australia. Unlike other next-generation sequencers that have read lengths of 100 to 700 bases, the PacBio long read sequencer generates an average read length of 8,000 bases and a maximum of 20,000 bases. It will be used for research in genomics, metagenomics and tr ....PacBio long read sequencer for the Ramaciotti Genomics Consortium of NSW. PacBio long read sequencer for the Ramaciotti Genomics Consortium of New South Wales: This will be one of the first PacBio sequencers for a service facility in Australia. Unlike other next-generation sequencers that have read lengths of 100 to 700 bases, the PacBio long read sequencer generates an average read length of 8,000 bases and a maximum of 20,000 bases. It will be used for research in genomics, metagenomics and transcriptomics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100506
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Specialised ribosomes: An unexplored regulatory layer to tune the proteome. This project aims to decipher human ribosome composition across tissues and conditions, and regulate its composition and activity (selective translation of subsets of transcripts) in a tissue-dependent, spatial and temporal manner – a major challenge in biology. Although ribosomes have been historically thought of as uniform entities, recent evidence suggests that their composition might be regulated. Elevating the expre ....Specialised ribosomes: An unexplored regulatory layer to tune the proteome. This project aims to decipher human ribosome composition across tissues and conditions, and regulate its composition and activity (selective translation of subsets of transcripts) in a tissue-dependent, spatial and temporal manner – a major challenge in biology. Although ribosomes have been historically thought of as uniform entities, recent evidence suggests that their composition might be regulated. Elevating the expression of a target protein without affecting mRNA levels is expected to benefit other disciplines, including biotechnology (e.g. recombinant protein expression), biomedicine (e.g. treatment of a human disease by suppression or enhancement of the levels of key disease-related proteins) and synthetic biology.Read moreRead less
The characterization of tiny Ribonucleic acids in animal epigenetics. Epigenetics, the inheritance of traits not encoded in deoxyribonucleic acid (DNA), is not well understood in animals. This project will investigate two classes of Ribonucleic acid (RNA) that may form part of an animal-specific epigenetic regulatory system. This study could revolutionize our understanding of animal genetics.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100130
Funder
Australian Research Council
Funding Amount
$850,000.00
Summary
Systems biology: New generation DNA sequencing to functional analysis. The technique of DNA sequencing (or 'reading' the lines of the four repeating letters that make up the genetic code) illustrates how technological developments have become the main drivers in exploring the roles of genetic factors across a spectrum of research activities. Funding provided through this ARC grant will allow the purchase of the latest DNA sequencing platform, the Illumina Solexa, as well as equipment that will b ....Systems biology: New generation DNA sequencing to functional analysis. The technique of DNA sequencing (or 'reading' the lines of the four repeating letters that make up the genetic code) illustrates how technological developments have become the main drivers in exploring the roles of genetic factors across a spectrum of research activities. Funding provided through this ARC grant will allow the purchase of the latest DNA sequencing platform, the Illumina Solexa, as well as equipment that will be used to understand the biological function of the DNA sequencing results that are obtained. The equipment will allow Australian researchers to compete on an equal footing with the international leaders in understanding the roles played by genes in plants, microorganisms, animals and humans.Read moreRead less