Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledg ....Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledge and ideas as well as advanced research and industrial training for young scientists. Knowledge derived from this project is expected to enable future innovation in molecules with tailored interactions with the glycocalyx with significant benefits for researchers, manufacturers and end users. Read moreRead less
Applications-oriented elucidation of germination triggers for Emu Bush seed. The project aims to determine the environmental and genetic mechanisms that currently limit seed germination in Emu Bush (Eremophila) species. The anticipated project outcomes aim to develop new technologies for efficient and mass production of Emu Bush seedlings. The outcomes will improve land restoration by increasing plant diversity and reducing establishment costs, and will also provide the nursery industry with nov ....Applications-oriented elucidation of germination triggers for Emu Bush seed. The project aims to determine the environmental and genetic mechanisms that currently limit seed germination in Emu Bush (Eremophila) species. The anticipated project outcomes aim to develop new technologies for efficient and mass production of Emu Bush seedlings. The outcomes will improve land restoration by increasing plant diversity and reducing establishment costs, and will also provide the nursery industry with novel products for home gardens. The intended project benefits are to increase the diversity of Australian native plants used for restoration and ornamental purposes and to promote the conservation of species in this plant family and its genetic diversity.Read moreRead less
Intelligent bioprocessing for next-generation nutritional yeast extracts. This project aims to provide new, science-based levers for optimising the industrial production of tailormade yeast extracts for food applications. Advanced biochemical and engineering methods will be used to develop new knowledge of the links between yeast growth conditions, cell biochemistry, processing and the flavour and texture profiles of yeast hydrolysates. This understanding will allow the properties of yeast hydro ....Intelligent bioprocessing for next-generation nutritional yeast extracts. This project aims to provide new, science-based levers for optimising the industrial production of tailormade yeast extracts for food applications. Advanced biochemical and engineering methods will be used to develop new knowledge of the links between yeast growth conditions, cell biochemistry, processing and the flavour and texture profiles of yeast hydrolysates. This understanding will allow the properties of yeast hydrolysates to be accurately tuned during yeast production and processing. The resulting process improvements and innovations will increase the efficiency and quality of current yeast extract products and allow the development of new food products.Read moreRead less
Understanding platinum dissolution in biomedical stimulating electrodes. Platinum is the main material used in electrodes for neurostimulators like the cochlear implant. Platinum electrodes can experience dissolution during implantation, which can impact on their function. The mechanisms governing this dissolution process are complex and still not fully understood. This research aims to understand the chemical, electrical and biological factors that impact on platinum dissolution in electrodes. ....Understanding platinum dissolution in biomedical stimulating electrodes. Platinum is the main material used in electrodes for neurostimulators like the cochlear implant. Platinum electrodes can experience dissolution during implantation, which can impact on their function. The mechanisms governing this dissolution process are complex and still not fully understood. This research aims to understand the chemical, electrical and biological factors that impact on platinum dissolution in electrodes. It will also develop new 3D models to simulate conditions in the human body for more rapid testing of electrodes. The new knowledge generated will improve the accuracy of predictions of platinum dissolution, develop new approaches for minimising dissolution, and contribute to reducing need for animal experimentation.Read moreRead less
Characterising the transport and delivery of oligonucleotides . Short RNA and DNA molecules represent a class of macromolecules that have great potential, but to facilitate their trafficking across cellular and membrane barriers into specific sites of action is challenging. This project aims to develop and apply novel imaging approaches to track them in cells and tissues. Expected outcomes include better understanding of the trafficking across cellular and membrane barriers, and improved imaging ....Characterising the transport and delivery of oligonucleotides . Short RNA and DNA molecules represent a class of macromolecules that have great potential, but to facilitate their trafficking across cellular and membrane barriers into specific sites of action is challenging. This project aims to develop and apply novel imaging approaches to track them in cells and tissues. Expected outcomes include better understanding of the trafficking across cellular and membrane barriers, and improved imaging tools that could be used to further study the molecular mechanisms of accumulation, metabolism and trafficking of these molecules. This project should provide new strategies to target these molecules to specific cells and tissues, which have significant social and economic benefits to the Australian community.Read moreRead less
Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by ....Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches.
Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption.
Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers. Read moreRead less