Platelet Glycoprotein Proteolysis: Novel Mechanisms And Risk Factors
Funder
National Health and Medical Research Council
Funding Amount
$441,473.00
Summary
Platelets are the richest source of amyloid precursor protein (APP) in the body. Platelet ADAM10 regulates both the expression and function of the major platelet collagen receptor GPVI, and protective APP processing. Coagulation protein Factor X has a role in activation of ADAM10. This activation is disrupted in blood that has been treated with direct oral anticoagulant (DOAC) rivaroxaban. This grant will investigate the implications for people taking rivaroxaban on regulation of APP and GPVI.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100087
Funder
Australian Research Council
Funding Amount
$1,100,000.00
Summary
Plasma-focused ion beam for nanoscale characterisation of materials. This project aims to enable research programmes in functional materials to characterise materials using xenon-plasma focused ion beam (FIB) instrumentation. The plasma FIB, with its fast milling speeds across large areas, will enable new three-dimensional imaging experiments and types of transmission electron microscopy samples. This will have applications in engineering, photovoltaics and environmental geosciences, which all n ....Plasma-focused ion beam for nanoscale characterisation of materials. This project aims to enable research programmes in functional materials to characterise materials using xenon-plasma focused ion beam (FIB) instrumentation. The plasma FIB, with its fast milling speeds across large areas, will enable new three-dimensional imaging experiments and types of transmission electron microscopy samples. This will have applications in engineering, photovoltaics and environmental geosciences, which all need to analyse materials on a nanometre scale.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100030
Funder
Australian Research Council
Funding Amount
$980,000.00
Summary
Returning Western Australian characterisation capabilities to the cutting edge: high resolution analytical transmission electron microscopy. From the design of future electronic devices to understanding the formation of valuable deposits of gold and iron, the atomic scale structure and composition of materials plays an important role. The electron microscope will aid internationally-recognised WA-based groups conducting high impact research underpinning the Australian economy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100006
Funder
Australian Research Council
Funding Amount
$1,060,000.00
Summary
Ultra-high resolution focussed ion beam facility for Western Australia. Ultra-high resolution focussed ion beam facility: An ultra-high resolution dual beam facility (incorporating ion and electron beams) will provide 3D imaging, site-specific analysis and nano-machining to a wide range of internationally recognised Australian researchers across a broad spectrum of disciplines in the geosciences, engineering, biological and physical sciences. Providing critically needed access to this world-clas ....Ultra-high resolution focussed ion beam facility for Western Australia. Ultra-high resolution focussed ion beam facility: An ultra-high resolution dual beam facility (incorporating ion and electron beams) will provide 3D imaging, site-specific analysis and nano-machining to a wide range of internationally recognised Australian researchers across a broad spectrum of disciplines in the geosciences, engineering, biological and physical sciences. Providing critically needed access to this world-class infrastructure is expected to advance international competitiveness, leading to high-impact outcomes in smart materials, nanotechnology, bioscience, and geoscience, including support for the Australian resources sector.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100075
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
Next Generation Small Angle X-Ray Scattering Facility. Next generation small angle X-ray scattering facility: The ability to determine the nanostructure of bulk materials is of utmost importance in an array of cutting-edge research fields. A state-of-the-art small angle X-ray scattering (SAXS) facility will address this for a wide range of materials covering a diverse range of research topics such as energy storage materials, catalytic species, drug delivery systems, protein structures, biologic ....Next Generation Small Angle X-Ray Scattering Facility. Next generation small angle X-ray scattering facility: The ability to determine the nanostructure of bulk materials is of utmost importance in an array of cutting-edge research fields. A state-of-the-art small angle X-ray scattering (SAXS) facility will address this for a wide range of materials covering a diverse range of research topics such as energy storage materials, catalytic species, drug delivery systems, protein structures, biological membranes, medical diagnostics and therapy, magnetic nanosystems, polymers, novel technologies for the clean utilisation of biomass, and minerals processing. The facility will underpin a range of current and planned multidisciplinary research programs leading to vital nanostructural information and innovative research solutions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100125
Funder
Australian Research Council
Funding Amount
$837,000.00
Summary
National Facility for Infrared Technologies. This project aims to establish a national facility for infrared (IR) technologies. The facility will include advanced imaging and spectroscopy facilities as well as unique tools for wafer-scale mapping of IR materials and devices. Combined, the facility will enable new diagnostic capabilities of supersonic combustion processes, aid establishment of wavelength agile integrated photonic chips and provide non-destructive quantitative electro-optical char ....National Facility for Infrared Technologies. This project aims to establish a national facility for infrared (IR) technologies. The facility will include advanced imaging and spectroscopy facilities as well as unique tools for wafer-scale mapping of IR materials and devices. Combined, the facility will enable new diagnostic capabilities of supersonic combustion processes, aid establishment of wavelength agile integrated photonic chips and provide non-destructive quantitative electro-optical characterisation of IR materials and devices. Establishment of these state-of-the-art capabilities across Australia will have clear benefits in fundamental sciences such as astronomy and quantum information as well as key industry branches in defence, aerospace, communications and security.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100121
Funder
Australian Research Council
Funding Amount
$670,000.00
Summary
A facility for the nanoscale imaging and characterisation of materials. Nanotechnology is dependent on measuring surface properties and this cutting-edge scanning probe microscopy facility will provide this capability. Atomic resolution imaging, along with spectroscopy for chemical information, and nanoindentation for physical information, will generate solutions for physical and life sciences, and materials engineering.
A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conduct ....A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conductance properties of the channel. Accurately
determining these relationships provides a pathway to developing cures
for many neurological, cardiac, and muscular diseases.
Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100192
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomole ....Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomolecules including peptides, proteins and small molecules. The discovery of unknown compounds is expected to improve fundamental understanding of molecular structure and function, provide opportunities for new bio-industries in health and the environment, and generate commercial opportunities through spin-off companies, patents and licensing.Read moreRead less