Molecular mechanisms of two-component signal transduction in bacteria. The focus of this research is on the protein complexes that transmit signals in bacteria to elicit the desired responses to environmental stimuli. Like many dynamic processes in cells, signaling requires proteins that are flexible and hence resistant to high-resolution structural analysis using crystallography. We will make use of new research infrastructure at the Australian synchrotron and OPAL research reactor to overcom ....Molecular mechanisms of two-component signal transduction in bacteria. The focus of this research is on the protein complexes that transmit signals in bacteria to elicit the desired responses to environmental stimuli. Like many dynamic processes in cells, signaling requires proteins that are flexible and hence resistant to high-resolution structural analysis using crystallography. We will make use of new research infrastructure at the Australian synchrotron and OPAL research reactor to overcome the challenges of flexibility in these systems. The proteins we will study are not found in humans, and hence our research will provide important structural data on potential targets for the design of novel antibiotics to fight bacterial infection.Read moreRead less
Unravelling the structural origin of cyclic fatigue in ferroelectrics. Ferroelectric materials have extensive applications in electromechanical devices and memories and in service are often subjected to repeat mechanical and/or electrical loading, leading to cyclic fatigue and failure. This project aims to apply in-situ electron microscopy techniques and computational modelling to explore cyclic ferroelectric fatigue behaviour and to understand the relationships between local atomic scale struct ....Unravelling the structural origin of cyclic fatigue in ferroelectrics. Ferroelectric materials have extensive applications in electromechanical devices and memories and in service are often subjected to repeat mechanical and/or electrical loading, leading to cyclic fatigue and failure. This project aims to apply in-situ electron microscopy techniques and computational modelling to explore cyclic ferroelectric fatigue behaviour and to understand the relationships between local atomic scale structure and fatigue. The structural origin of ferroelectric fatigue has not been clear because of the limitations of previous measurement capabilities. This project will provide guidance in materials design to increase ferroelectric fatigue lifetime for more reliable ferroelectric-based electronic devices.Read moreRead less
A Novel Multilevel Modelling Framework to Design Diamond Nanothread Bundles. This project aims to develop a novel, computationally-based framework to optimally and efficiently design new fibre materials based on the diamond nanothreads synthesized by the PI in 2014. The CIs (and others) have demonstrated the tremendous promise these materials hold to replace common carbon fibres. The proposed framework will combine advanced computer modelling, statistical learning, genetic algorithm-based optima ....A Novel Multilevel Modelling Framework to Design Diamond Nanothread Bundles. This project aims to develop a novel, computationally-based framework to optimally and efficiently design new fibre materials based on the diamond nanothreads synthesized by the PI in 2014. The CIs (and others) have demonstrated the tremendous promise these materials hold to replace common carbon fibres. The proposed framework will combine advanced computer modelling, statistical learning, genetic algorithm-based optimal design and experimental validations. It will accelerate the design of these new carbon-based fibres as game-changing materials in a wide range of areas. Ultimately this project has the potential to deliver significant economic benefits and will place Australia at the forefront of the industrial revolution of the future.Read moreRead less
Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nan ....Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nanowires through molecular dynamics simulations, empirical interatomic potential, and in situ TEM experiments. Expected outcomes include knowledge of the deformation mechanism of this layered titanate which can be broadened to technologically important layered ceramic materials.Read moreRead less
High Quality Gallium Oxide for Power Electronics. This project aims to combine advanced nanocharacterisation techniques with complementary expertise in semiconductor growth to produce high-quality gallium oxide that will enable fabrication of high efficiency, cost-effective power electronics. These state-of-the-art devices are urgently required to significantly reduce power conversion losses to maximise the performance and benefits of electricity generation systems using renewable energy sources ....High Quality Gallium Oxide for Power Electronics. This project aims to combine advanced nanocharacterisation techniques with complementary expertise in semiconductor growth to produce high-quality gallium oxide that will enable fabrication of high efficiency, cost-effective power electronics. These state-of-the-art devices are urgently required to significantly reduce power conversion losses to maximise the performance and benefits of electricity generation systems using renewable energy sources. The availability of superior oxide materials with bespoke electrical properties will enable the construction of fast high-voltage electronic switches, converters and other components with enhanced performance and unique capabilities.Read moreRead less
Nuclear Trafficking of Apolipoprotein-E. Apolipoprotein-E (apoE) regulates specific age-related neurodegenerative and cardiovascular diseases. The role of apoE in these disorders is unclear. This project will benefit our community by providing the basic cell biology knowledge required to understand disease mechanisms and ultimately provide avenues for better treatments. Aspects of the project will focus on the modification of apoE by carbohydrates and the interaction of apoE with cellular carboh ....Nuclear Trafficking of Apolipoprotein-E. Apolipoprotein-E (apoE) regulates specific age-related neurodegenerative and cardiovascular diseases. The role of apoE in these disorders is unclear. This project will benefit our community by providing the basic cell biology knowledge required to understand disease mechanisms and ultimately provide avenues for better treatments. Aspects of the project will focus on the modification of apoE by carbohydrates and the interaction of apoE with cellular carbohydrate-containing structures. The importance of carbohydrates in the regulation of cellular and protein function is increasingly recognised and forms a foundation for the rapidly expanding discipline of glycobiology. This project will strengthen Australia's glycobiology research capacity.Read moreRead less
Imaging Symmetry – A New Mechanism for Revealing the Structure of Matter. This project aims to develop a revolutionary method for imaging atomic structures. In this method, the image contrast derives from the symmetry of the structure, measured at the picometre scale, using tiny electron probes. This new conceptual approach is expected to overcome some of the key limitations of existing electron microscopy methods by providing increased sensitivity and reduced radiation damage, thereby enabling ....Imaging Symmetry – A New Mechanism for Revealing the Structure of Matter. This project aims to develop a revolutionary method for imaging atomic structures. In this method, the image contrast derives from the symmetry of the structure, measured at the picometre scale, using tiny electron probes. This new conceptual approach is expected to overcome some of the key limitations of existing electron microscopy methods by providing increased sensitivity and reduced radiation damage, thereby enabling complex structures in technologically important materials to be determined. This should provide new ways to understand the properties of these materials advanced materials and engineer them for applications in the energy, transport, health, communications and other sectors of society. Read moreRead less
Biogenesis and functions of bacterial membrane vesicles. This project aims to investigate the mechanisms that regulate the production of bacterial membrane vesicles and how this determines their bacterial cargo and subsequent biological functions. Bacterial membrane vesicles are naturally produced nanoparticles released by all bacteria as part of their normal growth. These vesicles contain a range of bacterial cargo and function to promote bacterial survival and growth. This project will advance ....Biogenesis and functions of bacterial membrane vesicles. This project aims to investigate the mechanisms that regulate the production of bacterial membrane vesicles and how this determines their bacterial cargo and subsequent biological functions. Bacterial membrane vesicles are naturally produced nanoparticles released by all bacteria as part of their normal growth. These vesicles contain a range of bacterial cargo and function to promote bacterial survival and growth. This project will advance our knowledge regarding the regulation of bacterial membrane vesicle biogenesis, their composition and biological functions. Collectively, these findings will facilitate the development and refinement of membrane vesicle-based biotechnologies with broad applications.Read moreRead less
Aberration-corrected atom probe tomography for materials engineering. Observing atomic-scale structure (AS) is key to unlocking advanced materials science and engineering (MSE).
Aims: We aim to (1) develop software that will enable the accurate observation of atoms in a material, and (2) apply this new software to additive manufactured alloys and quantum computing materials.
Significance: We expect to complete aberration-corrected atom probe tomography capability for the first time international ....Aberration-corrected atom probe tomography for materials engineering. Observing atomic-scale structure (AS) is key to unlocking advanced materials science and engineering (MSE).
Aims: We aim to (1) develop software that will enable the accurate observation of atoms in a material, and (2) apply this new software to additive manufactured alloys and quantum computing materials.
Significance: We expect to complete aberration-corrected atom probe tomography capability for the first time internationally. We intend to gain better insights into some longstanding questions in MSE that can only be answered by accurately observing AS.
Benefits: By making the outcomes commercially available, we aspire to improve consistency in the quality of products, and increased yield, that result from manufacturing processes.Read moreRead less
Making Strong Alloys Ductile and Hydrogen-Tolerant via Tuning Nanogradients. This project aims to develop a novel design concept of gradient segregation engineering (GSE) to produce high-performance alloys. The innovative GSE will synergistically introduce a chemical gradient via grain boundary segregation and a physical gradient by microstructure control to simultaneously achieve an excellent strength-ductility combination and exceptional resistance to hydrogen embrittlement. This project expec ....Making Strong Alloys Ductile and Hydrogen-Tolerant via Tuning Nanogradients. This project aims to develop a novel design concept of gradient segregation engineering (GSE) to produce high-performance alloys. The innovative GSE will synergistically introduce a chemical gradient via grain boundary segregation and a physical gradient by microstructure control to simultaneously achieve an excellent strength-ductility combination and exceptional resistance to hydrogen embrittlement. This project expects to create new fundamental knowledge and provide critical perspectives for future mechanistic alloy design. The results will enhance Australia’s capacity to develop next-generation advanced alloys to underpin current and emerging industrial applications and strengthen the country’s leading position in materials engineering.Read moreRead less