Every cell in our body has an intrinsic orientation that is controlled by a universal set of genes known as polarity genes. Loss of this orientation is a common and early feature of cancer. We have identified the gene Scribble as a gene that controls cell orientation and is essential to prevent the development of prostate cancer. We propose experiments to discover how Scribble controls prostate cancer and whether it can be used to better predict outcome for prostate cancer patients.
Activation And Suppression Of Oncogenic Translocation By Uracil-DNA Glycosylases
Funder
National Health and Medical Research Council
Funding Amount
$513,000.00
Summary
The AID enzyme is implicated in cancer in B lymphocytes and prostate cells. AID causes DNA damage normally recognised by repair enzymes UNG and MutS?, among others. The repair processes these factors initiate involve a DNA break that, if incorrectly re-joined, destabilises the genome, causing cancer. Understanding the function of AID, UNG and MutS? in B cell lymphomas and prostate cancer will provide fundamental insights into cancer and may identify targets for new therapeutics.