Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
Hydrogen generation by subsurface iron mineral transformations. Aim
The aim of this project is to elucidate key factors responsible for natural hydrogen generation in Australian subsurface environments.
Significance
Large amounts of this valuable resource are produced naturally with estimates of production rates of this “gold” hydrogen at least 100 times the annual demand for this critical resource.
Expected Outcomes
Based on improved understanding of the source of natural hydrogen, predictive ....Hydrogen generation by subsurface iron mineral transformations. Aim
The aim of this project is to elucidate key factors responsible for natural hydrogen generation in Australian subsurface environments.
Significance
Large amounts of this valuable resource are produced naturally with estimates of production rates of this “gold” hydrogen at least 100 times the annual demand for this critical resource.
Expected Outcomes
Based on improved understanding of the source of natural hydrogen, predictive tools will be developed that will assist in assessing the viability in Australia of hydrogen exploration and engineered retrieval.
Benefits
Ready access to naturally produced hydrogen could enable Australia to replace hydrogen that is currently generated via the use of unabated hydrocarbons.Read moreRead less
The global vaccination revolution: a transnational and comparative perspective. A study of first global immunization campaign will provide a historical dimension to contemporary concerns about pandemic disease, vaccination and bio-terrorism, and generate new insights into the factors determining the success and failure of public health initiatives. The project relates directly to national research priorities in health and safeguarding Australia. It has more specific relevance to Australia. Small ....The global vaccination revolution: a transnational and comparative perspective. A study of first global immunization campaign will provide a historical dimension to contemporary concerns about pandemic disease, vaccination and bio-terrorism, and generate new insights into the factors determining the success and failure of public health initiatives. The project relates directly to national research priorities in health and safeguarding Australia. It has more specific relevance to Australia. Smallpox decimated the Aboriginal population, and quarantine and vaccination have loomed large in Australian history. It builds on Australia's strong scholarship in the fields of virology and immunology and the history of disease and public health.Read moreRead less
The World Arm-to-Arm: The Spread of Smallpox Vaccination and Global Networks of Knowledge and Power, 1799-1805. This project will document the rapid spread of Jenner's vaccine around the world between 1799 and 1805. It will address matters neglected in the existing literature, including the logistics of the global transmission of the vaccine, often literally arm-to-arm; the promotion and reception of vaccination in different social and cultural contexts; and the networks of power and knowledge ....The World Arm-to-Arm: The Spread of Smallpox Vaccination and Global Networks of Knowledge and Power, 1799-1805. This project will document the rapid spread of Jenner's vaccine around the world between 1799 and 1805. It will address matters neglected in the existing literature, including the logistics of the global transmission of the vaccine, often literally arm-to-arm; the promotion and reception of vaccination in different social and cultural contexts; and the networks of power and knowledge that made the Jennerian revolution possible. The project will result in a book and articles, interventions in the literature on globalisation and the adoption of innovation, and a deeper and broader perspective on issues of burning relevance to the world today.Read moreRead less
From risk factor analysis to translation: multiple sclerosis and vitamin D deficiency. This research on multiple sclerosis will focus on its causes and lifestyle factors that affect it and will trial vitamin D supplementation as a treatment. Studies on vitamin D deficiency in healthy populations aim to develop new public health recommendations on sun exposure and vitamin D that balance risk of skin cancer against vitamin D deficiency.
The Derwent project: immersive digital media visualisations for the representational problems of complex and remote environments. The Derwent Project will create new ways to visualise the complex natural and cultural history of Tasmania’s Derwent River system. This vast and often inaccessible environment includes Aboriginal and colonial heritage alongside ten hydroelectric developments. Its multiple layers of space and time present new opportunities to synthesise artistic and scientific paradigm ....The Derwent project: immersive digital media visualisations for the representational problems of complex and remote environments. The Derwent Project will create new ways to visualise the complex natural and cultural history of Tasmania’s Derwent River system. This vast and often inaccessible environment includes Aboriginal and colonial heritage alongside ten hydroelectric developments. Its multiple layers of space and time present new opportunities to synthesise artistic and scientific paradigms of representation by drawing on geography, history, and archaeology. The outcome will be innovative forms of immersive time-based digital imaging that evocatively reveal hidden layers of environmental information to both specialist and general audiences.Read moreRead less
Critical windows: understanding changes in eating and physical activity over the transition from secondary school to young adulthood. This project will explain changes in eating, physical activity and sedentary behaviour during the critical period of transition from secondary school to young adulthood. It will provide important information on how we can assist adolescents to maintain a healthy lifestyle over a time characterised by several major life changes.
Listen to me, I really am sick! Understanding patient and family perspectives in triggering responses to medical emergencies. This project investigates whether patient and family perspectives are treated as evidence of a deteriorating health state whilst in hospital. Recommendations from this study will inform the development of patient centred strategies to reduce delays in clinician response to physiological deterioration and improve patient safety in hospitals.
Translational research in osteoarthritis: from epidemiological studies to clinical interventions. Currently the only treatment for osteoarthritis is to relieve pain. However, there are some factors that may affect the progression of this disease. This project will examine these factors including inflammation, metabolism, and physical inactivity, and find potential modifying therapies such as vitamin D supplementation for osteoarthritis.
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less