The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Modulation Of Leishmaniasis By The Proinflammatory Cytokines TNF
Funder
National Health and Medical Research Council
Funding Amount
$288,911.00
Summary
We have established a mouse model that has been genetically modified and cannot produce the cytokine tumour necrosis factor. This cytokine is secreted in the beginning of the inflammatory response. If these mice are infected with a parasite they are not able to heal the infection and die quickly. We can demonstrate that these mice cannot regulate the beginning inflammatory response and do not form a cellular infiltrate at the site of infection.
Hemokinin - A New Inflammatory Mediator In The Intestine.
Funder
National Health and Medical Research Council
Funding Amount
$382,768.00
Summary
Inflammatory bowel disease and acute diverticular disease are two serious and very costly inflammatory disorders of the bowel. Tachykinins are known to be causally involved in inflammation-induced bowel dysfunction. A new tachykinin peptide, hemokinin, is found in immune cells, but has not been studied at all in the intestine. In this project, we will study the effects of hemokinin on human bowel immune function. The study will provide essential information to formulate new treatments.
Does CD123 Provide A Biological Advantage To Leukaemia Stem Cells?
Funder
National Health and Medical Research Council
Funding Amount
$647,637.00
Summary
Leukaemia is a devastating form of blood cancer affecting both young and old. We need to understand the diseased stem cell to eradicate this disease. Current therapy is poorly tolerated and the majority of patients ultimately die at relapse. We intend to investigate how we can make the cells more susceptible to therapy by understanding their biology.
Cytokine Signalling And The Regulation Of Normal And Leukaemic Blood Cells
Funder
National Health and Medical Research Council
Funding Amount
$948,684.00
Summary
The formation and actions of white blood cells are regulated by protein messengers called cytokines. Cytokines deliver their message by inducing the activation of signalling pathways that orchestrate the cell’s response to infection but when these responses occur too robustly or at inappropriate times they can lead to autoimmune disease, tissue damage and blood cancers. We study the naturally occurring feedback inhibitors of these processes in order to devise new treatments for these diseases.
Understanding The Pharmacology Of G-CSF For Treating Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$429,393.00
Summary
Heart attacks remain the most common cause of heart failure. Unlike many other tissues the heart is unable to repair itself. Recently it has been recognised that bone marrow cells promote to a small degree repair. Our research confirms these findings and indicates that these can be affected by substances that increase the circulating bone marrow cell numbers. This project will explore how bone marrow cells improve repair and ways to further improve efficacy.
Exploring And Targeting The Anti-Inflammatory Signalling Mechanisms Of Interleukin 37
Funder
National Health and Medical Research Council
Funding Amount
$1,018,306.00
Summary
Cytokines are messenger proteins that function as master regulators of biological processes; thus they play central roles in many diseases. The rare cytokines that block inflammation do so by dampening the immune system’s potentially destructive force, making them attractive targets for drug development. We showed that interleukin 37 is a powerful anti-inflammatory cytokine, and will now evaluate its mechanisms of action and its efficacy against several severe diseases, including cancer.
Hematopoietic Cytokines For The Repair Of Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$334,375.00
Summary
Heart attacks remain one of the most common causes of heart failure. Unlike many other tissues such as the skin or bone marrow, the heart is unable to repair itself following a heart attack. Recently it has been recognised that bone marrow cells can to a small degree repair the heart. How this is done is not known but it may be due to the formation of new blood vessels and perhaps new heart muscle. Unfortunately, the repair by bone marrow cells is not very efficient. One way of improving the eff ....Heart attacks remain one of the most common causes of heart failure. Unlike many other tissues such as the skin or bone marrow, the heart is unable to repair itself following a heart attack. Recently it has been recognised that bone marrow cells can to a small degree repair the heart. How this is done is not known but it may be due to the formation of new blood vessels and perhaps new heart muscle. Unfortunately, the repair by bone marrow cells is not very efficient. One way of improving the efficiency of heart repair by bone marrow cells is to give people bone marrow growth factors that increase the number of bone marrow cells in the blood and thus, increase the number at the site of heart injury. Our preliminary research shows that this is the case although the efficiency of repair is still not enough as a useful therapy. This project will examine how bone marrow growth factors improve heart repair following heart attacks and explore ways of improving the efficiency of repair to permit trials in humans.Read moreRead less
Cytokine-driven Allergic Inflammation: Characterization Of Two Isoform-specific Modes Of IL-3 Receptor Activation And Investigation Of New Receptor-associated Signalling Partners.
Funder
National Health and Medical Research Council
Funding Amount
$620,716.00
Summary
In asthma, the symptoms are caused by an allergic reaction in the lung orchestrated by immune cells which produce small proteins called cytokines thus stimulating inflammatory cell production. The cytokine IL-3 is critical for the production of basophils which have an important role in the inflammation. The project will investigate the molecular details of how the IL-3 binds to its receptor and stimulates basophil production and reveal new targets for controlling inflammation in asthma.