Molecular Regulation Of Tumourigenesis By The Polarity Determinant Scribble And Associated Proteins
Funder
National Health and Medical Research Council
Funding Amount
$614,421.00
Summary
Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have shown that Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble promotes breast cancer using a combination of tissue culture studies and a newly established mouse model. Understanding how this new pathway can regulate breast tumour development may provide novel targets for therapeutic intervention in cancer.
Activation And Suppression Of Oncogenic Translocation By Uracil-DNA Glycosylases
Funder
National Health and Medical Research Council
Funding Amount
$513,000.00
Summary
The AID enzyme is implicated in cancer in B lymphocytes and prostate cells. AID causes DNA damage normally recognised by repair enzymes UNG and MutS?, among others. The repair processes these factors initiate involve a DNA break that, if incorrectly re-joined, destabilises the genome, causing cancer. Understanding the function of AID, UNG and MutS? in B cell lymphomas and prostate cancer will provide fundamental insights into cancer and may identify targets for new therapeutics.
Analysis Of Rho GTPase Signalling Pathways In An Epithelial To Mesenchymal Transition During Development Of The Mesoderm
Funder
National Health and Medical Research Council
Funding Amount
$409,500.00
Summary
A critical step in the progression of cancers that are derived from epithelial tissues is a transition from an epithelial cell type to a migratory mesenchymal cell type that can spread to other parts of the body. This change in cell behaviour also occurs, apparently by a similar mechanism, during the development of some normal tissue types. Here we propose to use an animal model of this process, coupled with advanced molecular genetic and cell biological techniques, to investigate a newly discov ....A critical step in the progression of cancers that are derived from epithelial tissues is a transition from an epithelial cell type to a migratory mesenchymal cell type that can spread to other parts of the body. This change in cell behaviour also occurs, apparently by a similar mechanism, during the development of some normal tissue types. Here we propose to use an animal model of this process, coupled with advanced molecular genetic and cell biological techniques, to investigate a newly discovered cell signalling mechanism required for the transition of cells from an epithelial form to a mesenchymal form. Understanding the molecular steps in this new pathway and discovering new genes involved will provide tools for understanding and preventing the metastasis of cancer cells.Read moreRead less
Regulation Of Cell Death, Cell Survival And Ubiquitination In Normal Physiology And Disease
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
I am a cellular and molecular biologist with extensive training in a number of biomedical research areas. For over 20 years I have used my training and skills to understand the normal functioning of the body and what molecular and cellular changes underlie various diseases. This fellowship will allow me to continue the groundbreaking work we have been doing to explore the function of several proteins in diseases such as cancer, hypertension, lung inflammation and anaemia.