Towards High-performance and Fault-tolerant Distributed Java Implementations. Java Virtual Machines form an important part of the web and business
server market. Distributed Java Virtual Machines have the potential to
make a significant contribution to industries that utilize this
technology. An attractive platform for this purpose is the
cluster, a highly cost-effective and scalable parallel computer
model. However, realizing on such a platform a high performance virtual
machine implem ....Towards High-performance and Fault-tolerant Distributed Java Implementations. Java Virtual Machines form an important part of the web and business
server market. Distributed Java Virtual Machines have the potential to
make a significant contribution to industries that utilize this
technology. An attractive platform for this purpose is the
cluster, a highly cost-effective and scalable parallel computer
model. However, realizing on such a platform a high performance virtual
machine implementation tolerant to hardware and software faults, and
having efficient memory utilization, presents many challenging research
issues. This project will address these issues by extending a highly
efficient and extensible Java implementation to be aware of its cluster
environment.
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Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistr ....Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistry application package, and also with a major international computer company. Our aim is to substantially improve the performance of this code on cluster based compute systems. This, as well as our generic performance evaluation tools, would be of substantial benefit to the Australian research community. The project will forge links with researchers in Singapore, Japan and the USA.Read moreRead less
Programming Paradigms, Tools and Algorithms for the Spectral Solution of the Electronic Schroedinger Equation on Non-Uniform Memory Parallel Processors. We propose to develop software tools and methods that are appropriate for current and future generations of large scale shared memory computer systems. Our purpose is to enable a more productive utilization of these architectures for scientific computation. We will focus on algorithms for solving differential equations appropriate to quantum che ....Programming Paradigms, Tools and Algorithms for the Spectral Solution of the Electronic Schroedinger Equation on Non-Uniform Memory Parallel Processors. We propose to develop software tools and methods that are appropriate for current and future generations of large scale shared memory computer systems. Our purpose is to enable a more productive utilization of these architectures for scientific computation. We will focus on algorithms for solving differential equations appropriate to quantum chemistry. In particular an exciting new class of methods whose computational cost scales linearly with system size. Our goal is to develop scalable parallel implementations of these methods. If realized this will revolutionize computation, enabling first principles calculations on truly nanoscale systems, such as enzymes and molecular electronic devices.Read moreRead less
Accurate Performance Modelling and Prediction of Cluster Computers. The tools, methodologies and data produced by this project will assist
Australian academic and industrial organisations in choosing the most
cost-effective cluster configurations for their specific high
performance computing requirements. It will also help an Australian
company to compete with increasing strength against the major
multinationals. The project will also draw together and promote future
research links between ....Accurate Performance Modelling and Prediction of Cluster Computers. The tools, methodologies and data produced by this project will assist
Australian academic and industrial organisations in choosing the most
cost-effective cluster configurations for their specific high
performance computing requirements. It will also help an Australian
company to compete with increasing strength against the major
multinationals. The project will also draw together and promote future
research links between two major academic institutions in this field.
Finally, the project will provide high-level training in research,
with industrial grounding, in the high performance computing industry.
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Structures and Protocols for Inference. The proposed research is expected to lead to increased adoption and efficiency of use of machine learning technologies. It will develop new and better ways to use existing machine learning software in a manner that allows easier integration into commercial products. It will increase the competitiveness of Australian industry.
Next Generation Grid Enabled Cluster Computers: Performance Optimisation for e-Science. In partnership with a local computer company this project will develop cost effective cluster computing solutions assembled from off-the-shelf parts for $50,000-$200,000. This price range is currently relatively poorly serviced by the multinational computer vendors, who tend to focus on the high density compute systems necessary for very large cluster systems. As a consequence the development of high performa ....Next Generation Grid Enabled Cluster Computers: Performance Optimisation for e-Science. In partnership with a local computer company this project will develop cost effective cluster computing solutions assembled from off-the-shelf parts for $50,000-$200,000. This price range is currently relatively poorly serviced by the multinational computer vendors, who tend to focus on the high density compute systems necessary for very large cluster systems. As a consequence the development of high performance computing in Australia has been somewhat stifled compared to the US or UK, where there exist small niche companies servicing this market sector. This project aims to change this, developing affordable high performance cluster computing systems for the Australian market place and beyond.Read moreRead less
Verified concurrent memory management on modern processors. This project aims to formally verify automatic memory managers in the presence of concurrency and the weakly ordered memory of modern processors. A new framework for verifying memory managers, reusable for a wide range of managed programming languages, target hardware, policies, and algorithms will be developed. Expected technical outcomes include improved techniques to ensure trustworthiness of the foundations on which critical softwar ....Verified concurrent memory management on modern processors. This project aims to formally verify automatic memory managers in the presence of concurrency and the weakly ordered memory of modern processors. A new framework for verifying memory managers, reusable for a wide range of managed programming languages, target hardware, policies, and algorithms will be developed. Expected technical outcomes include improved techniques to ensure trustworthiness of the foundations on which critical software infrastructures are built. This will significantly enhance the security of public and private cyber assets, and deliver applications that are more robust and trustworthy, across a range of critical infrastructure such as transportation, communication, energy and defence.Read moreRead less
Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101081
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis t ....Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis to efficiently and precisely analyse large-scale programs according to clients’ needs, thereby allowing compilers to generate safe, reliable and secure code. This project is expected to advance value-flow analysis for industrial-sized software, improve software reliability and security, and benefit Australian software systems and industries.Read moreRead less
Early Nutrition, Epigenetics And Developmental Outcomes In Children.
Funder
National Health and Medical Research Council
Funding Amount
$550,093.00
Summary
Increasing evidence demonstrates that early nutrition, including in pregnancy, has long lasting programming effects on later health of children. Evidence implicates epigenetics (literally ‘above DNA’) in mediating these effects. The most convincing data exists for obesity and related disorders such as metabolic syndrome, diabetes, and heart disease. The focus of this project is on understanding how ‘epigenetic’ mechanisms are influencing the way our genes function to cause these disorders.