A Case-control Study Of Rotavirus Vaccine Effectiveness Against Gastroenteritis Hospitalisation Of Children In The NT
Funder
National Health and Medical Research Council
Funding Amount
$465,859.00
Summary
Almost 1 out of 5 children in remote Aboriginal communities are hospitalised with diarrhoea caused by rotavirus. This study will evaluate the impact of rotavirus vaccination in preventing these hospitalisations. In addition to making sure that vaccination works and that those at highest risk are receiving the benefits, it will assess the indirect impact against other causes of diarrhoea providing, critical information relevant to the vaccine's broader introduction in developing country settings.
Predictive Models And Interventions For Coronary Heart Disease In Aboriginal And Torres Strait Islander People
Funder
National Health and Medical Research Council
Funding Amount
$203,125.00
Summary
The main causes of heart disease in western countries are smoking, high blood pressure and high cholesterol. However, in indigenous populations, other factors may be more important. We propose to look at these conventional risk factors and others like diabetes, blood clotting disorders and inflammation to see which are best for predicting heart attack in Aboriginal and Torres Strait Islander people . We will also examine the effect of heart disease prevention programs run by communities, to see ....The main causes of heart disease in western countries are smoking, high blood pressure and high cholesterol. However, in indigenous populations, other factors may be more important. We propose to look at these conventional risk factors and others like diabetes, blood clotting disorders and inflammation to see which are best for predicting heart attack in Aboriginal and Torres Strait Islander people . We will also examine the effect of heart disease prevention programs run by communities, to see if they can improve these risk factors. Finally, we will use this information to produce educational materials and clinical tools for health services.Read moreRead less
Pharmacogenetics Of Methadone Maintenance Treatment
Funder
National Health and Medical Research Council
Funding Amount
$355,564.00
Summary
There is large amount of inter-individual variability in response to methadone use in dependence programmes. Many factors are involved including age, disease and the use of other drugs. Until recently a person's genetic makeup was not amongst these factors. Our study will show how genetic variability that alters the transport or the drug target in the body impacts on a person's drug response and side effects to methadone used to treat opioid dependence.
Inter-rater Reliability And Predictive Validity Of A New Functional Capacity Evaluation For Chronic Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$105,794.00
Summary
Back pain costs the Australian community tens of billions of dollars. Back pain is one of the main causes of work injury and lost time from work. The longer a person is off work, the harder it is to get them back to work. Workers' compensation systems around Australia aim at getting the injured worker with back pain back to work as soon as possible. One of the difficulties in this process is determining what the person with back pain can physically do in the workplace. An evaluation technique, c ....Back pain costs the Australian community tens of billions of dollars. Back pain is one of the main causes of work injury and lost time from work. The longer a person is off work, the harder it is to get them back to work. Workers' compensation systems around Australia aim at getting the injured worker with back pain back to work as soon as possible. One of the difficulties in this process is determining what the person with back pain can physically do in the workplace. An evaluation technique, called functional capacity evaluation (known as FCE), is one method used to find out what the person with back pain physically can and cannot do. In a FCE, a trained health professional such as an occupational therapist, observes the person performing a range of physical activities like the ones he or she may have to perform in a job. The therapist closely observes the person performing activities such as lifting, carrying, kneeling, crouching, balancing, and walking and notes any limitations in the person's ability to complete the activities. The therapist makes comments about what difficulties the person may have on the job and recommendations about how these could be reduced or eliminated. The information gained from these evaluations can be valuable for the treating doctor in deciding whether the person is ready to go back to work and what duties the person can and cannot do on the job. Because of such value they provide, FCE is commonly used in rehabilitation programs endorsed by workers' compensation systems around Australia. This widespread use and endorsement of FCE occurs despite limited research on the soundness of the ratings made from these evaluations. There is a need to see whether recommendations made from FCEs are consistent between therapists (i.e. reliable) and to see if the FCE accurately predicts the person's physical capacity for work. This research will examine these issues with injured workers with back pain.Read moreRead less
The Effect Of Iron Supplementation In Pregnancy On Child Cognitive Development
Funder
National Health and Medical Research Council
Funding Amount
$91,562.00
Summary
During fetal life the brain grows very rapidly and animal studies have shown that inadequate iron nutrition of mothers during pregnancy can result in permanent structural and developmental problems in the offspring. Although this has not been examined in human infants, new studies suggest that the iron stores of the mother in pregnancy are an important determinant of the baby's iron stores during the first year of life. It may be that the critical period where iron nutrition influences later dev ....During fetal life the brain grows very rapidly and animal studies have shown that inadequate iron nutrition of mothers during pregnancy can result in permanent structural and developmental problems in the offspring. Although this has not been examined in human infants, new studies suggest that the iron stores of the mother in pregnancy are an important determinant of the baby's iron stores during the first year of life. It may be that the critical period where iron nutrition influences later development is in fetal life (during pregnancy). We have the opportunity to test whether iron nutrition in fetal life influences childhood development by assessing the cognitive abilities of children who were in our earlier study of iron supplementation in pregnancy. Our aim is to assess the children at 4 years to determine if iron nutrition in pregnancy predicts development. This may change the dietary advice we give pregnant women to ensure they give their babies the best start in life.Read moreRead less
Randomised Controlled Trial Of Multimedia Patient Education Approaches To Preventing In-hospital Falls
Funder
National Health and Medical Research Council
Funding Amount
$524,137.00
Summary
In hospital falls are one of the most frequently occurring adverse events in Australian hospitals. They are the cause of considerable patient morbidity, stress to family members and care givers, and health care resource use. However, there are many potential causes of in-hospital falls which has made minimising them a difficult task for hospitals around the country. Recent evidence has indicated that a patient intervention strategy is useful for preventing in-hospital falls as a part of a multi- ....In hospital falls are one of the most frequently occurring adverse events in Australian hospitals. They are the cause of considerable patient morbidity, stress to family members and care givers, and health care resource use. However, there are many potential causes of in-hospital falls which has made minimising them a difficult task for hospitals around the country. Recent evidence has indicated that a patient intervention strategy is useful for preventing in-hospital falls as a part of a multi-factorial falls prevention program. This research aims to investigate the effectiveness and economic benefit of two approaches to providing patient education for the prevention of in-hospital falls. Patients at high risk for falls will be recruited from the Princess Alexandra Hospital and be randomly allocated to either a DVD + 4 sessions of face-to-face education with an occupational therapist program, to a DVD alone education program, or to a usual care with no additional education control condition. Patients will be followed up until their discharge from hospital and the number of in-hospital falls they incur will be compared between groups. It is expected that both the DVD + 4 sessions of face-to-face education with an occupational therapist program, to a DVD alone education program will be effective in reducing falls and that the DVD alone education program will demonstrate the greater cost-effectiveness in reducing falls. Stemming from this research, it is anticipated that a cost-effective resource for preventing in-hospital falls will be developed and evaluated such that it can be used in hospitals Australia wide.Read moreRead less
The IDEAL Trial - Initiating Dialysis Early And Late
Funder
National Health and Medical Research Council
Funding Amount
$752,500.00
Summary
Kidney replacement therapy by dialysis has in the past been provided for patients with endstage renal failure once their remaining kidney function has deterioriated to less than 5-10% of normal. There has been an increasing trend in recent years to offer dialysis therapy at an earlier stage of kidney failure, such that more than 20% of dialysis patients in Australia (and up to 35% in some subgroups) now commence that therapy when their remaining kidney function is greater than 10%. This change h ....Kidney replacement therapy by dialysis has in the past been provided for patients with endstage renal failure once their remaining kidney function has deterioriated to less than 5-10% of normal. There has been an increasing trend in recent years to offer dialysis therapy at an earlier stage of kidney failure, such that more than 20% of dialysis patients in Australia (and up to 35% in some subgroups) now commence that therapy when their remaining kidney function is greater than 10%. This change has occurred because of the unproven belief that earlier dialysis may be associated with a better health outcome. However, dialysis treatment is associated with complications and it is very expensive. Therefore, it is important to determine the health and economic consequences of commencing dialysis early rather than late. The IDEAL trial (Initiating Dialysis Early And Late) is a large multi-centre study being conducted in many renal units in Australia and New Zealand, which will determine whether it is better, in terms of health outcomes and total cost of treatment, to commence dialysis at a time when remaining kidney function is between 10 and 14% or between 5 and 7% of normal.Read moreRead less