Implementation Of A New, Inexpensive And High-throughput Matrix Assisted Laser Desorption / Ionization _ Time Of Flight Mass Spectrometry Test For Superior Detection Of Fragile X Syndrome In Targeted Diagnostics And Newborn Population Screening.
Funder
National Health and Medical Research Council
Funding Amount
$254,175.00
Summary
Background: The Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability. There are now a number of treatments for FXS. However, often this disorder is not clearly recognized. We have developed a novel FXS test that could resolve this issue. Our objective is to develop a commercial package that describes suitability of our test for diagnostic use. If successful this could potentially leading to improvement in the prognosis for FXS children through early treatment int ....Background: The Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability. There are now a number of treatments for FXS. However, often this disorder is not clearly recognized. We have developed a novel FXS test that could resolve this issue. Our objective is to develop a commercial package that describes suitability of our test for diagnostic use. If successful this could potentially leading to improvement in the prognosis for FXS children through early treatment intervention.Read moreRead less
A Unified Grid Programming Methodology for Global e-Science. This project will contribute to the national benefit in three important ways. First, we will build a set of novel e-Science applications as demonstrator projects in areas of national priority. These will have enormous economic impact in areas ranging from environmental management to health. Second, we will build software infrastructure that will have both commercial and strategic value in its own right. Third, we shall build a critical ....A Unified Grid Programming Methodology for Global e-Science. This project will contribute to the national benefit in three important ways. First, we will build a set of novel e-Science applications as demonstrator projects in areas of national priority. These will have enormous economic impact in areas ranging from environmental management to health. Second, we will build software infrastructure that will have both commercial and strategic value in its own right. Third, we shall build a critical mass of expertise that bridges the physical sciences and computer science. The support provided to this proposal will allow multi-disciplinary teams to address scientific problems of significant scale.Read moreRead less
Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and ....Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and techniques. The expected outcomes include novel software, verified by industry partners in real world case studies, ranging from life sciences to hypersonic transport. This should provide significant benefits, including the capacity for Australian industries to access world-class supercomputing technology.Read moreRead less
Large-Scale Emulation for Enterprise Software Systems. This project will deliver a key future software technology for scalable quality assurance of highly interconnected enterprise IT systems, significantly contributing to more reliable and effective business operations in all industry sectors. It will fill a market gap and give Australian businesses a world competitive advantage. The project will generate world-leading research outcomes and further cement Australia’s leading research position i ....Large-Scale Emulation for Enterprise Software Systems. This project will deliver a key future software technology for scalable quality assurance of highly interconnected enterprise IT systems, significantly contributing to more reliable and effective business operations in all industry sectors. It will fill a market gap and give Australian businesses a world competitive advantage. The project will generate world-leading research outcomes and further cement Australia’s leading research position in enterprise software systems engineering. In particular, it will make major contributions to research into complex large-scale system interaction, system performance and scalability, and system behaviour modelling. The project also provides an excellent training environment for young researchers. Read moreRead less
Preventing sensitive data exfiltration from insiders . Confidential data such as military secrets or intellectual property must never be disclosed outside the organisation; formally protecting data exfiltration from insider attacks is a major challenge. This project aims to develop a pattern matching based systematic methodology for data exfiltration in database systems. We will devise highly accurate detection tools and secure provenance techniques that can effectively protect against insider a ....Preventing sensitive data exfiltration from insiders . Confidential data such as military secrets or intellectual property must never be disclosed outside the organisation; formally protecting data exfiltration from insider attacks is a major challenge. This project aims to develop a pattern matching based systematic methodology for data exfiltration in database systems. We will devise highly accurate detection tools and secure provenance techniques that can effectively protect against insider attacks. The outcomes of the project will incorporate new security constraints and policies raised by emerging technologies to enable better protection of sensitive information. Read moreRead less
Resource Allocation for High-Volume Streaming Data in Data Centers. Almost all chip vendors are producing new hardware accelerators by combining several units into a single main-board, and therefore making the execution of parallel and distributed run-time primitives not efficient/scalable. This project aims to develop innovative ways to building incremental and iterative computations over massive data sets in a cluster of heterogeneous systems. This will provide a significant reduction of perfo ....Resource Allocation for High-Volume Streaming Data in Data Centers. Almost all chip vendors are producing new hardware accelerators by combining several units into a single main-board, and therefore making the execution of parallel and distributed run-time primitives not efficient/scalable. This project aims to develop innovative ways to building incremental and iterative computations over massive data sets in a cluster of heterogeneous systems. This will provide a significant reduction of performance bottlenecks when running heavily distributed data-driven applications. Expected outcomes will include resource management algorithms that optimise performance at large scale. The project will benefit many areas, including running stateful iterative stream-based data-analysis applications in data centres. Read moreRead less
A scalable debugging framework for petascale computers. Supercomputing underpins a wide range of areas of importance to the Australian economy; mining, agriculture, engineering, medical research and pharmaceutical development to name a few. It is of critical importance that software solutions in these areas behave correctly and do not generate erroneous results. This project will develop software tools and techniques that make it possible to detect and locate errors as software is converted to r ....A scalable debugging framework for petascale computers. Supercomputing underpins a wide range of areas of importance to the Australian economy; mining, agriculture, engineering, medical research and pharmaceutical development to name a few. It is of critical importance that software solutions in these areas behave correctly and do not generate erroneous results. This project will develop software tools and techniques that make it possible to detect and locate errors as software is converted to run on the next generation of 'petascale' supercomputers. We will deploy the tools both commercially through our industry partner, and also on national high performance computing facilities.Read moreRead less
Adaptive Vector Filters for the Restoration of Digital Colour Images. Colour image restoration has very important applications in colour cameras, robotic navigation, video security systems, multimedia communications, and digital TV broadcast. Conventional vector filters have difficulty in simultaneously achieving three major objectives: noise suppression, detail preservation, and chromaticity retention. This project aims at formulating and evaluating novel adaptive filters to accomplish the th ....Adaptive Vector Filters for the Restoration of Digital Colour Images. Colour image restoration has very important applications in colour cameras, robotic navigation, video security systems, multimedia communications, and digital TV broadcast. Conventional vector filters have difficulty in simultaneously achieving three major objectives: noise suppression, detail preservation, and chromaticity retention. This project aims at formulating and evaluating novel adaptive filters to accomplish the three objectives simultaneously. Theoretical basis will be investigated for devising different adaptive filters to restore colour images and video sequences contaminated by various types of noise. The new filters will provide significant improvement over exiting techniques, yielding better tools and packages for colour image processing and restoration applications.Read moreRead less
Economic Scheduling for Efficient Management of Clusters and their Cooperative Federation. Clusters of commodity computers have emerged as mainstream parallel and distributed platforms for high-performance computing. They are presented together as a single, unified resource to the end users by middleware technologies such as resource management and scheduling (RMS) systems. However, existing cluster RMS systems continue to use system centric models rather than utility models for the management a ....Economic Scheduling for Efficient Management of Clusters and their Cooperative Federation. Clusters of commodity computers have emerged as mainstream parallel and distributed platforms for high-performance computing. They are presented together as a single, unified resource to the end users by middleware technologies such as resource management and scheduling (RMS) systems. However, existing cluster RMS systems continue to use system centric models rather than utility models for the management and allocation of resources. There is also little emphasis on the construction of a cooperative federation of clusters to facilitate transparent sharing of resources. To enhance the value delivered by shared clusters, we propose the use of computational economy metaphor in resource management. This project aims to develop (A) computational economy based scheduling policies for allocation of resources and (B) a software infrastructure for creation of cooperative federation of distributed clusters.Read moreRead less
Reputation-based Trust Framework for Composed Services. This project aims at providing a uniform and efficient framework for bootstrapping, establishing, and propagating reputation in composed Web services. Reputation is used as a key criterion for establishing trust among composed Web services. Web services are de-facto the technology of choice for the deployment of an increasing number of Web-based solutions for such emerging applications as cloud computing. Because of the distributed and dece ....Reputation-based Trust Framework for Composed Services. This project aims at providing a uniform and efficient framework for bootstrapping, establishing, and propagating reputation in composed Web services. Reputation is used as a key criterion for establishing trust among composed Web services. Web services are de-facto the technology of choice for the deployment of an increasing number of Web-based solutions for such emerging applications as cloud computing. Because of the distributed and decentralised nature of the Web, there is a need to establish a trust framework for selecting and composing Web services. The key parameter will be based on Web service reputation in delivering services.Read moreRead less