Implementation Of A New, Inexpensive And High-throughput Matrix Assisted Laser Desorption / Ionization _ Time Of Flight Mass Spectrometry Test For Superior Detection Of Fragile X Syndrome In Targeted Diagnostics And Newborn Population Screening.
Funder
National Health and Medical Research Council
Funding Amount
$254,175.00
Summary
Background: The Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability. There are now a number of treatments for FXS. However, often this disorder is not clearly recognized. We have developed a novel FXS test that could resolve this issue. Our objective is to develop a commercial package that describes suitability of our test for diagnostic use. If successful this could potentially leading to improvement in the prognosis for FXS children through early treatment int ....Background: The Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability. There are now a number of treatments for FXS. However, often this disorder is not clearly recognized. We have developed a novel FXS test that could resolve this issue. Our objective is to develop a commercial package that describes suitability of our test for diagnostic use. If successful this could potentially leading to improvement in the prognosis for FXS children through early treatment intervention.Read moreRead less
A Unified Grid Programming Methodology for Global e-Science. This project will contribute to the national benefit in three important ways. First, we will build a set of novel e-Science applications as demonstrator projects in areas of national priority. These will have enormous economic impact in areas ranging from environmental management to health. Second, we will build software infrastructure that will have both commercial and strategic value in its own right. Third, we shall build a critical ....A Unified Grid Programming Methodology for Global e-Science. This project will contribute to the national benefit in three important ways. First, we will build a set of novel e-Science applications as demonstrator projects in areas of national priority. These will have enormous economic impact in areas ranging from environmental management to health. Second, we will build software infrastructure that will have both commercial and strategic value in its own right. Third, we shall build a critical mass of expertise that bridges the physical sciences and computer science. The support provided to this proposal will allow multi-disciplinary teams to address scientific problems of significant scale.Read moreRead less
Large-Scale Emulation for Enterprise Software Systems. This project will deliver a key future software technology for scalable quality assurance of highly interconnected enterprise IT systems, significantly contributing to more reliable and effective business operations in all industry sectors. It will fill a market gap and give Australian businesses a world competitive advantage. The project will generate world-leading research outcomes and further cement Australia’s leading research position i ....Large-Scale Emulation for Enterprise Software Systems. This project will deliver a key future software technology for scalable quality assurance of highly interconnected enterprise IT systems, significantly contributing to more reliable and effective business operations in all industry sectors. It will fill a market gap and give Australian businesses a world competitive advantage. The project will generate world-leading research outcomes and further cement Australia’s leading research position in enterprise software systems engineering. In particular, it will make major contributions to research into complex large-scale system interaction, system performance and scalability, and system behaviour modelling. The project also provides an excellent training environment for young researchers. Read moreRead less
A scalable debugging framework for petascale computers. Supercomputing underpins a wide range of areas of importance to the Australian economy; mining, agriculture, engineering, medical research and pharmaceutical development to name a few. It is of critical importance that software solutions in these areas behave correctly and do not generate erroneous results. This project will develop software tools and techniques that make it possible to detect and locate errors as software is converted to r ....A scalable debugging framework for petascale computers. Supercomputing underpins a wide range of areas of importance to the Australian economy; mining, agriculture, engineering, medical research and pharmaceutical development to name a few. It is of critical importance that software solutions in these areas behave correctly and do not generate erroneous results. This project will develop software tools and techniques that make it possible to detect and locate errors as software is converted to run on the next generation of 'petascale' supercomputers. We will deploy the tools both commercially through our industry partner, and also on national high performance computing facilities.Read moreRead less
Adaptive Vector Filters for the Restoration of Digital Colour Images. Colour image restoration has very important applications in colour cameras, robotic navigation, video security systems, multimedia communications, and digital TV broadcast. Conventional vector filters have difficulty in simultaneously achieving three major objectives: noise suppression, detail preservation, and chromaticity retention. This project aims at formulating and evaluating novel adaptive filters to accomplish the th ....Adaptive Vector Filters for the Restoration of Digital Colour Images. Colour image restoration has very important applications in colour cameras, robotic navigation, video security systems, multimedia communications, and digital TV broadcast. Conventional vector filters have difficulty in simultaneously achieving three major objectives: noise suppression, detail preservation, and chromaticity retention. This project aims at formulating and evaluating novel adaptive filters to accomplish the three objectives simultaneously. Theoretical basis will be investigated for devising different adaptive filters to restore colour images and video sequences contaminated by various types of noise. The new filters will provide significant improvement over exiting techniques, yielding better tools and packages for colour image processing and restoration applications.Read moreRead less
Economic Scheduling for Efficient Management of Clusters and their Cooperative Federation. Clusters of commodity computers have emerged as mainstream parallel and distributed platforms for high-performance computing. They are presented together as a single, unified resource to the end users by middleware technologies such as resource management and scheduling (RMS) systems. However, existing cluster RMS systems continue to use system centric models rather than utility models for the management a ....Economic Scheduling for Efficient Management of Clusters and their Cooperative Federation. Clusters of commodity computers have emerged as mainstream parallel and distributed platforms for high-performance computing. They are presented together as a single, unified resource to the end users by middleware technologies such as resource management and scheduling (RMS) systems. However, existing cluster RMS systems continue to use system centric models rather than utility models for the management and allocation of resources. There is also little emphasis on the construction of a cooperative federation of clusters to facilitate transparent sharing of resources. To enhance the value delivered by shared clusters, we propose the use of computational economy metaphor in resource management. This project aims to develop (A) computational economy based scheduling policies for allocation of resources and (B) a software infrastructure for creation of cooperative federation of distributed clusters.Read moreRead less
Reputation-based Trust Framework for Composed Services. This project aims at providing a uniform and efficient framework for bootstrapping, establishing, and propagating reputation in composed Web services. Reputation is used as a key criterion for establishing trust among composed Web services. Web services are de-facto the technology of choice for the deployment of an increasing number of Web-based solutions for such emerging applications as cloud computing. Because of the distributed and dece ....Reputation-based Trust Framework for Composed Services. This project aims at providing a uniform and efficient framework for bootstrapping, establishing, and propagating reputation in composed Web services. Reputation is used as a key criterion for establishing trust among composed Web services. Web services are de-facto the technology of choice for the deployment of an increasing number of Web-based solutions for such emerging applications as cloud computing. Because of the distributed and decentralised nature of the Web, there is a need to establish a trust framework for selecting and composing Web services. The key parameter will be based on Web service reputation in delivering services.Read moreRead less
A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will d ....A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will develop, whilst focused on heart tissue, will have broader applicability, and may underpin advancements in other disciplines. Finally, we expect that the software solutions and infrastructure will have both commercial and strategic value in their own right.Read moreRead less
An active approach to detect and defend against peer-to-peer botnets. The aim of this project is to develop an effective defence system to help organisations detect and defend against the peer-to-peer (P2P) botnets. If this research is accomplished successfully, it will be a big step forward in defeating this new but devastating malicious software widely utilised by Internet criminals and terrorists. The capability of a nation to defend against the P2P botnet attacks on its information infrastru ....An active approach to detect and defend against peer-to-peer botnets. The aim of this project is to develop an effective defence system to help organisations detect and defend against the peer-to-peer (P2P) botnets. If this research is accomplished successfully, it will be a big step forward in defeating this new but devastating malicious software widely utilised by Internet criminals and terrorists. The capability of a nation to defend against the P2P botnet attacks on its information infrastructure is central to the control of such attacks and hence to a nation's long-term survival and prosperity. The outcomes of this project can be directly used in Australian research communities and adopted by industry and government agencies.Read moreRead less
Software debuggers for next generation heterogeneous supercomputers. Supercomputing underpins a wide range of areas of importance to the Australian economy; mining, agriculture, engineering and medical research to name a few. It is of critical importance that software solutions in these areas behave correctly. This project will develop software tools and techniques to help locate errors in such applications.