Improved models to understand the genomic architecture of complex traits. This project aims to improve modelling of the genetics underlying complex traits. The project will develop and test models for using genome-wide genetic data to investigate how much heritability (genetic effect) underlies traits of interest, where it lies in the genome, and how much of it is shared across traits. The new models will be implemented in statistical algorithms in a freely-available software package. This proj ....Improved models to understand the genomic architecture of complex traits. This project aims to improve modelling of the genetics underlying complex traits. The project will develop and test models for using genome-wide genetic data to investigate how much heritability (genetic effect) underlies traits of interest, where it lies in the genome, and how much of it is shared across traits. The new models will be implemented in statistical algorithms in a freely-available software package. This project expects to increase understanding of biological mechanisms, the efficiency of genetic association analyses and the accuracy of genomic prediction, including the effects of interventions. The project will adapt human models to a wider range of organisms, in particular bacteria.Read moreRead less
Elucidating the genetic basis of newly evolved metabolic functions in yeast. Elucidating the genetic basis of newly evolved metabolic functions in yeast. This project intends to research how complex metabolic pathways originate and evolve. This project will use cutting edge genome sequencing and molecular techniques to elucidate the heritable genetic basis of Baker’s yeast, which has been the selectively evolved to use xylose as a sole carbon source: something vital for second generation biofuel ....Elucidating the genetic basis of newly evolved metabolic functions in yeast. Elucidating the genetic basis of newly evolved metabolic functions in yeast. This project intends to research how complex metabolic pathways originate and evolve. This project will use cutting edge genome sequencing and molecular techniques to elucidate the heritable genetic basis of Baker’s yeast, which has been the selectively evolved to use xylose as a sole carbon source: something vital for second generation biofuel production that wild yeast cannot do. This project will combine detailed molecular characterisation of highly adapted yeast strains with a novel "molecular palaeontology" approach to trace the evolutionary process and identify functionally significant loci under selection. Detailed characterisation of this trait will accelerate the development of future yeast strains and test fundamental evolutionary theories.Read moreRead less
Is restoration working? An ecological genetic assessment. This project aims to assess the success of restoration in terms of ecological and genetic viability for plant species in the Fitzgerald River–Stirling Range region of Western Australia, where significant investment is being made in restoring connectivity at a landscape scale. The project intends to compare reproductive output, pollinator behaviour, mating, genetic diversity and pollen dispersal in restored sites with those of undisturbed ....Is restoration working? An ecological genetic assessment. This project aims to assess the success of restoration in terms of ecological and genetic viability for plant species in the Fitzgerald River–Stirling Range region of Western Australia, where significant investment is being made in restoring connectivity at a landscape scale. The project intends to compare reproductive output, pollinator behaviour, mating, genetic diversity and pollen dispersal in restored sites with those of undisturbed natural vegetation. The project moves measures of restoration success beyond that of population establishment and survival to incorporate the evolutionary processes that provide long-term resilience, persistence and functional integration of restored populations into broader landscapes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100460
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
Role of DNA methylation in response to low nutrient availability in plants. DNA methylation (mC) is a covalent modification of DNA essential for the establishment and maintenance of correct gene expression patterns and recently suggested to be responsive to some environmental cues in plants. Using cutting edge technologies, this project aims to identify nutrient stress-induced mC changes and investigate the role that these changes may play in transcriptional regulation, as well as assessing whet ....Role of DNA methylation in response to low nutrient availability in plants. DNA methylation (mC) is a covalent modification of DNA essential for the establishment and maintenance of correct gene expression patterns and recently suggested to be responsive to some environmental cues in plants. Using cutting edge technologies, this project aims to identify nutrient stress-induced mC changes and investigate the role that these changes may play in transcriptional regulation, as well as assessing whether these changes can be transmitted to the next generation to confer intergenerational stress responsiveness. Altogether this project aims to provide fundamental knowledge of the role of mC in plant gene regulation and stress response as well as paving the way for the next generation of novel crop-improvement strategies.Read moreRead less
HEN1 is a regulator of piRNA metabolism, transcriptional regulation and mammalian male fertility. This project is to define the biochemistry of a previously uncharacterized protein in male fertility using a unique mouse model and innovative DNA and protein technologies. This project will define a novel, and essential, pathway for male fertility and may ultimately have relevance to the maintenance of health or improving fertility.
The Cape honey bee and the origins of virgin birth. Using honeybees, the aim is to show how a mutation in a single gene creates a new species. This gene causes a shift from sexual to asexual reproduction, allowing workers to clone themselves (virgin birth), thus turning a formerly cooperative species into a social cancer. Observing a real-time speciation event driven by a single gene is an incredibly rare opportunity and enables this project to determine the socio-genetic mechanisms that reduce ....The Cape honey bee and the origins of virgin birth. Using honeybees, the aim is to show how a mutation in a single gene creates a new species. This gene causes a shift from sexual to asexual reproduction, allowing workers to clone themselves (virgin birth), thus turning a formerly cooperative species into a social cancer. Observing a real-time speciation event driven by a single gene is an incredibly rare opportunity and enables this project to determine the socio-genetic mechanisms that reduce gene flow between neighbouring populations and to explain how expression of the gene is regulated. Further, because clonal reproduction often leads to invasiveness in social insects - a dangerous outcome - understanding the origins of virgin birth is also critical to understanding invasiveness.Read moreRead less
Accelerated Domestication of Australian Grass Species Using Molecular Tools. The development of new food crops from the Australian flora will provide opportunities for new sustainable agricultural and food industries in Australia. The project targets the accelerated domestication of native species with lower tillage and fertiliser requirements, better water use efficiencies and increased salt, shade, frost and/or drought tolerances than the current introduced cereal and fodder crops. This will ....Accelerated Domestication of Australian Grass Species Using Molecular Tools. The development of new food crops from the Australian flora will provide opportunities for new sustainable agricultural and food industries in Australia. The project targets the accelerated domestication of native species with lower tillage and fertiliser requirements, better water use efficiencies and increased salt, shade, frost and/or drought tolerances than the current introduced cereal and fodder crops. This will directly benefit regional Australia. The technologies developed in the project will have wide application to accelerated domestication of other Australian plants (for agriculture and food production in Australia and internationally) and to plants found in other parts of the world.Read moreRead less
The role of long non-coding RNAs in the epigenetic control of gene expression during endosperm development in plants. Elucidating the molecular events underlying the biology of seed development is important in both understanding plant development and in developing new methods to enhance the productivity and qualities of grain crops. In recent years it has become clear that various classes of non-coding RNAs have important roles in gene regulation. Of these non-coding RNAs, small RNAs (20-25 nucl ....The role of long non-coding RNAs in the epigenetic control of gene expression during endosperm development in plants. Elucidating the molecular events underlying the biology of seed development is important in both understanding plant development and in developing new methods to enhance the productivity and qualities of grain crops. In recent years it has become clear that various classes of non-coding RNAs have important roles in gene regulation. Of these non-coding RNAs, small RNAs (20-25 nucleotides) are beginning to be understood however less is known about the role and complexity of long non-coding RNAs. This project would identify new regulators of seed development that may lead to novel methods to increase grain yields, ultimately benefitting the Australian grains industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100225
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Western Australia single-cell isolation and genomics preparation facility. This project aims to give Western Australian researchers direct access to new platforms in single-cell isolation and single-cell RNA, genome and exome sample library preparation, so they can participate in the precision single-cell based research driving biology worldwide. This project will give researchers access to single-cell analysis techniques, integrated with other analysis methods, microscopy, and preclinical imagi ....Western Australia single-cell isolation and genomics preparation facility. This project aims to give Western Australian researchers direct access to new platforms in single-cell isolation and single-cell RNA, genome and exome sample library preparation, so they can participate in the precision single-cell based research driving biology worldwide. This project will give researchers access to single-cell analysis techniques, integrated with other analysis methods, microscopy, and preclinical imaging. The characterisation of rare and complex biological samples is expected to advance effective, socio-economically important research programmes in cell and molecular biology, sports science, plant and crop sciences, agriculture, clean energy (biofuels) resources and production, greenhouse gas reduction, environmental microbiology and marine science.Read moreRead less