Development of a new diet to improve insulin sensitivity and manage weight in healthy cats. This project will determine if a low carbohydrate, moderate fat, high protein diet improves insulin sensitivity and reduces weight gain in cats compared to a typical high-carbohydrate grocery line diet. It will identify risk factors for weight gain such as increased fasting insulin concentration and will also determine which simple assessment of insulin sensitivity best correlates with insulin sensitivity ....Development of a new diet to improve insulin sensitivity and manage weight in healthy cats. This project will determine if a low carbohydrate, moderate fat, high protein diet improves insulin sensitivity and reduces weight gain in cats compared to a typical high-carbohydrate grocery line diet. It will identify risk factors for weight gain such as increased fasting insulin concentration and will also determine which simple assessment of insulin sensitivity best correlates with insulin sensitivity measured by a gold standard. This project should lead to the formulation of a diet designed to improve insulin sensitivity and minimize weight gain in cats, and allow for earlier identification of cats at risk of obesity.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC150100026
Funder
Australian Research Council
Funding Amount
$3,732,019.00
Summary
ARC Training Centre for Fruit Fly Biosecurity Innovation. ARC Training Centre for Fruit Fly Biosecurity Innovation. This training centre aims to transform the way that horticulture industries combat invasive fruit flies that threaten Australian crops, which are valued at $9 billion per year. For generations, Australia has relied on insecticides to protect crops. Owing to environmental damage and concerns for consumer health, the most effective insecticides have recently been banned for use on ma ....ARC Training Centre for Fruit Fly Biosecurity Innovation. ARC Training Centre for Fruit Fly Biosecurity Innovation. This training centre aims to transform the way that horticulture industries combat invasive fruit flies that threaten Australian crops, which are valued at $9 billion per year. For generations, Australia has relied on insecticides to protect crops. Owing to environmental damage and concerns for consumer health, the most effective insecticides have recently been banned for use on many crops leaving no equivalent replacements. Horticulture industries are unprepared for this change, and are in desperate need of new sustainable practices to combat fruit flies. New researchers who are trained in both scientific approach and practical application will be well placed to deliver these new tools.Read moreRead less
How to make antibiotics in pig feed redundant, naturally. Antimicrobial resistance has become a major issue in human and veterinary medicine being partially caused by the use of in-feed antimicrobials in farm animals. This project aims to completely eliminate antimicrobials from piglet feeds. The key differential approach is based on helping the physiology of the animal rather than testing interventions against bacteria. The project will consist of developing a novel nutritional strategy of natu ....How to make antibiotics in pig feed redundant, naturally. Antimicrobial resistance has become a major issue in human and veterinary medicine being partially caused by the use of in-feed antimicrobials in farm animals. This project aims to completely eliminate antimicrobials from piglet feeds. The key differential approach is based on helping the physiology of the animal rather than testing interventions against bacteria. The project will consist of developing a novel nutritional strategy of naturally (through maternal conditioning) boosting the natural appetite and the capacity to digest in piglets early in life. The anticipated outcome is that the new peri-natal program will result in minimal bacterial proliferation and diarrhoea thus, negating the need for in-feed antimicrobials in piglets. Read moreRead less
Signaling Pathways To Enhance Potency Of AMPK-targeting Drugs
Funder
National Health and Medical Research Council
Funding Amount
$661,966.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to epidemics of obesity-related metabolic diseases that place enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Our goal is to improve AMPK drug potency by identifying novel processes that sensitize AMPK to drugs.
Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide ....Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.
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Tailoring physiologically-based nanomaterial fertilisers for the biofortification of zinc in broadacre crops. Soil zinc deficiency is a global issue causing low crop yield and malnutrition. This project will develop a new class of fertiliser formulations by combining advanced chemistry techniques with plant physiology knowledge and nanomaterial manufacturing. These products will be designed for enhanced agronomic efficiency and environmental safety.
The Integrated Bio-economy Project and the Controlled Biosphere. This project aims to develop advanced controlled environment production systems (Controlled Biosphere) that exceed the industry standard for profitability, sustainability and climatic resilience. It will generate new knowledge and innovations in technology integration through a highly multi-disciplinary approach. The project outcomes will yield Techno-Economic and Life-Cycle Analyses, designs of the Controlled Biosphere and support ....The Integrated Bio-economy Project and the Controlled Biosphere. This project aims to develop advanced controlled environment production systems (Controlled Biosphere) that exceed the industry standard for profitability, sustainability and climatic resilience. It will generate new knowledge and innovations in technology integration through a highly multi-disciplinary approach. The project outcomes will yield Techno-Economic and Life-Cycle Analyses, designs of the Controlled Biosphere and supporting policy frameworks. The benefits of this project address worsening resource constraints (e.g. available fresh water, arable land, nutrients); By 2050 we will require 70% more food, and 80% greenhouse gas emissions reductions, to maintain economic, social, political and climate security.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100025
Funder
Australian Research Council
Funding Amount
$2,259,000.00
Summary
ARC Training Centre in Food Safety in the Fresh Produce Industry. ARC Training Centre in Food Safety in the Fresh Produce Industry. This centre aims to create an innovation platform of food safety researchers and industry personnel who can significantly advance the safety of fruit and vegetables in Australia. The intended outcomes are safer food, leading to enhanced health and wellbeing; industry growth in the food/agribusiness sector; enhanced trust and international reputation; and increased a ....ARC Training Centre in Food Safety in the Fresh Produce Industry. ARC Training Centre in Food Safety in the Fresh Produce Industry. This centre aims to create an innovation platform of food safety researchers and industry personnel who can significantly advance the safety of fruit and vegetables in Australia. The intended outcomes are safer food, leading to enhanced health and wellbeing; industry growth in the food/agribusiness sector; enhanced trust and international reputation; and increased access to growing export markets. Intended benefits to industry are ready-to-use technologies for strengthened food safety, and a new generation of highly-skilled food safety scientists with experience in conducting industry-focused research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100040
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Integrated Greenhouse Gas Measurement System (IGMS) for monitoring agricultural emissions at field to regional scales. Measurement of greenhouse gases is critical to Australia’s obligations to reduce carbon emissions. The measurement facility will provide urgently needed accurate emission data from Australian agriculture to establish emission baselines and develop methods to extend the point-scale measurements to whole farm, regional and national scales.
A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.