The Identification Of Thoracic Targets For Prevention And Intervention In Bronchopulmonary Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The persistence of breathing problems from infancy to later life is a complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle. We will find out how much the heart, lungs and diaphragm contribute to breathing problems in babies; helping us to better predict, diagnose and treat severe breathing problems in babies born preterm.
Identifying Strategies To Reduce The Risk Of Kneecap Arthritis After Serious Knee Ligament Injury
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Early-onset kneecap arthritis, and associated pain and disability, affects younger adults at an alarming rate after serious knee ligament injury – “young people, old knees”. This research aims to identify modifiable risk factors for early-onset kneecap arthritis (reconstruction surgery, knee biomechanics and functional deficits) which will aid the development of interventions to minimise onset and progression of kneecap arthritis, and reduce the burden of this important public health problem.
Advancement Of A Personalised Approach To Minimising Infective Complications In Cancer Care
Funder
National Health and Medical Research Council
Funding Amount
$265,138.00
Summary
Managing infections in patients with cancer have become more difficult and unpredictable because of new generation cancer therapies. Measuring the response of the immune system (immune profiling) will allow us to predict which patients will develop infection so that action such as vaccination can be taken to reduce their risk. This program will refine immune profiling to personalise infection care for cancer patients and to introduce it into hospital practice.
Sensorimotor Control Of Foot Function: Adapting The Mechanical Function Of The Foot To Optimise Balance And Gait Performance
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Walking and running places immense load on our feet, with 20% of adults suffering from foot pain. Recent research has highlighted the important role of the muscles within the foot in facilitating our ability to withstand excessive load and maintain balance. But it remains unknown how the nervous system controls this function. This research will explore how the brain and spinal cord control these muscles, providing a comprehensive understanding of the role of the foot in balance and gait.
Sperm Methylation Status Predicts Embryo And Pregnancy Outcomes In Male Obesity
Funder
National Health and Medical Research Council
Funding Amount
$358,411.00
Summary
The incidence of male obesity in reproductively age men is epidemic and continually rising with close to 70% of men of reproductive age classified as overweight or obese. Male obesity is not only associated with sub fertility but also changes to pregnancy outcomes and influencing child health. This project will try to uncover the molecular changes in sperm, providing potential mechanisms for the abnormal foetal and pregnancy health seen as a result of male obesity.
Sequencing Periodontal Bacteria To Determine The Relationship Between Periodontits, Renal And Vascular Function Among Indigenous Australian Adults With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$329,644.00
Summary
Almost 20% of Indigenous Australian adults exhibit signs of kidney disease. This study will investigate the relationship between sub-gingival (below the gum) bacteria and both kidney and artery function among Indigenous Australian participants with chronic kidney disease. Using an RCT design, the proposed study will investigate whether changes in sub-gingival bacteria and concentration following conventional treatment of periodontitis align with improvements in renal and vascular function.