Investigate The Role Of PAF And CD40 Ligand In Regulating The Proinflammatory Properties Of Platelets
Funder
National Health and Medical Research Council
Funding Amount
$507,270.00
Summary
The cells of the blood play an important role in maintaining healthy blood vessels. We are interested in two types of blood cells, platelets and leukocytes, which together play a key role in vessel maintenance, by promoting blood clot formation and vessel wall repair following injury. However, while critical for normal blood vessel maintenance, these cells have also been demonstrated to contribute to disease states including atherosclerosis, thrombosis and inflammatory airway diseases. Underlyin ....The cells of the blood play an important role in maintaining healthy blood vessels. We are interested in two types of blood cells, platelets and leukocytes, which together play a key role in vessel maintenance, by promoting blood clot formation and vessel wall repair following injury. However, while critical for normal blood vessel maintenance, these cells have also been demonstrated to contribute to disease states including atherosclerosis, thrombosis and inflammatory airway diseases. Underlying the function of both blood cell types is their ability to stick (or adhere) to each other. However the way in which they coordinate this adhesion is very complex. New information from our laboratory has demonstrated that the sticky behaviour of each cell type is spatially and temporally regulated, and may involve may factors both inside and outside of the cells themselves. Our studies aim to define the key components regulating the 'stickiness' of these blood cells, in order to undertand how they contribute to maintaining healthy vessel walls, but also how their stickiness may also contribute to the promotion of diseased vessels. This information will not only increase our knowledge of the factors that regulate blood clot formation, but may also assist in the development of new therapies to prevent and-or treat vessel disease.Read moreRead less
New metal-molecule binding motifs for self-assembled monolayers and nanodevices. The goal of this research is to investigate technologically interesting electronic materials using new molecular assemblies. We explore their application in some fundamental components of molecular electronic systems and anticipate that knowledge gained from our investigations will have significant impact on the field of nanotechnology, especially in the area of molecular electronics. Our basic research will contrib ....New metal-molecule binding motifs for self-assembled monolayers and nanodevices. The goal of this research is to investigate technologically interesting electronic materials using new molecular assemblies. We explore their application in some fundamental components of molecular electronic systems and anticipate that knowledge gained from our investigations will have significant impact on the field of nanotechnology, especially in the area of molecular electronics. Our basic research will contribute to Australia's reputation as a source of innovative research and ideas in an area where there is growing international momentum.Read moreRead less
Special Research Initiatives - Grant ID: SR180100030
Funder
Australian Research Council
Funding Amount
$1,103,883.00
Summary
Development of electrochemically activated sorbents for PFAS defluorination. This project aims to develop a new treatment technology to completely defluorinate per- and poly-fluroalkyl substances (PFAS) and to treat significant water quantities. The majority of existing water treatment technologies are unable to remove PFAS to the desired extent, are prohibitively expensive or are only useful for a very limited lifespan. This project is expected to develop a new treatment technology with the abi ....Development of electrochemically activated sorbents for PFAS defluorination. This project aims to develop a new treatment technology to completely defluorinate per- and poly-fluroalkyl substances (PFAS) and to treat significant water quantities. The majority of existing water treatment technologies are unable to remove PFAS to the desired extent, are prohibitively expensive or are only useful for a very limited lifespan. This project is expected to develop a new treatment technology with the ability to completely defluorinate PFAS, treat significant water quantities and help address many of the pressing concerns facing water treatment operators. This technology is also scalable, and can potentially be used to treat significant quantities of contaminated water.Read moreRead less
A Nanomedicine Strategy For Detecting And Modulating Protease Activity In Vivo
Funder
National Health and Medical Research Council
Funding Amount
$455,534.00
Summary
Protease enzymes are vitally important for normal bodily function but can play a deleterious role in many diseases such as cancer, aging diseases and eye diseases. The proposed research will provide a nanomedicine solution to the detection and therapeutic control of protease activity in vivo using nanoporous optical devices that are benign to the body. This general strategy for will be demonstrated in eyes with a view to detection and treating the eye disease uveitis.